Características moleculares de Staphylococcus aureus suscetível à vancomicina poderia ajudar a prever falhas no tratamento devido à reduzida suscetibilidade à vancomicina

Rossato, Adriana Medianeira; Reiter, Keli Cristine; Soares, Renata Oliveira; Paim, Thiago Galvão da Silva; Sambrano, Gustavo Enck; Azevedo, Pedro Alves d'

doi:10.17058/reci.v8i4.11393

Cited by 3 publications

(3 citation statements)

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“…In the present study, 177 MRSA (81.6%) isolates exhibited resistance to at least one of the non-beta-lactam antimicrobials tested, which is indicative of the high resistance rates for erythromycin, ciprofloxacin, and clindamycin antimicrobials. These resistance rates are in accordance with findings from other studies in southern [28][29][30] and other regions of Brazil 31,32 .…”

Section: Discussionsupporting

confidence: 93%

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Resistance profile to antimicrobials agents in methicillin-resistant Staphylococcus aureus isolated from hospitals in South Brazil between 2014-2019

Rossato

Primon-Barros

Rocha

et al. 2020

Rev. Soc. Bras. Med. Trop.

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Introduction: Methicillin-resistant Staphylococcus aureus (MRSA) is a common pathogen causing healthcare-associated infections. Owing to the restricted use of beta-lactams in MRSA infections, non-beta-lactam antimicrobials are required for treatment. However, MRSA can develop resistance mechanisms to non-beta-lactam antimicrobials, which reduces viable treatment options. Here, we evaluated the antimicrobial susceptibility and resistance genes of MRSA isolated from hospitalized patients in South Brazil. Methods: The antimicrobial susceptibilities of hospital MRSA (217) isolates were determined by disk diffusion or microdilution methods. Additionally, the presence of 14 resistance genes and SCCmec typing was performed by PCR. Results: Among the antimicrobials tested, we observed high erythromycin (74.2%), ciprofloxacin (64.5%), and clindamycin (46.1%) resistance rates and complete susceptibility to linezolid and vancomycin. Seventeen different patterns of MRSA antimicrobial resistance were observed, of which 42.9% represented multidrug resistance. Among erythromycin-resistant MRSA, 53.4%, 45.3%, 37.9%, 13.0%, and 6.8% carried ermA, msrA, msrB, ermC, and ermB genes, respectively. Among clindamycin-resistant MRSA, 83%, 17%, 10%, 4%, and 2% carried ermA, ermC, ermB, linA, and linB genes, respectively. Among gentamicin-resistant MRSA, 96.8%, 83.9%, and 9.7% carried aac(6')/aph(2''), aph(3')-IIIa, and ant(4')-Ia genes, respectively. Among tetracycline-resistant MRSA, 6.5% and 93.5% carried tetK and tetM genes, respectively. Lastly, among trimethoprim/sulfamethoxazole-resistant MRSA, 13.3% and 100% carried dfrA and dfrG genes, respectively. The SCCmec type IV isolates were detected more frequently, whereas the SCCmec type III isolates exhibited higher multidrug resistance. Conclusions: The study data provides information regarding the MRSA resistance profile in South Brazil that is associated with the clinical conditions of patients and can contribute to clinical decision-making.

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Section: Discussionsupporting

confidence: 93%

“…In this study, the rates for trimethoprim-sulfamethoxazole, tetracycline, and gentamicin resistance were observed to be low, which was consistent with recent reports from other studies conducted in Brazil 29 , 31 .…”

Section: Discussionsupporting

confidence: 92%

Resistance profile to antimicrobials agents in methicillin-resistant Staphylococcus aureus isolated from hospitals in South Brazil between 2014-2019

Rossato

Primon-Barros

Rocha

et al. 2020

Rev. Soc. Bras. Med. Trop.

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“…Although systemic antibiotics are currently one of the most important and effective methods to treat bone infections, their use can lead to bacterial biofilm and bacterial resistance. For example, vancomycin is the gold standard in the treatment of methicillin-resistant S. aureus (MRSA) infection, but the minimum inhibitory concentration (MIC) of vancomycin in the treatment of MRSA is on the rise ( Satola et al, 2011 ; Rossato et al, 2018 ; Aljohani et al, 2020 ).…”

Section: Introductionmentioning

confidence: 99%

Implantable biomedical materials for treatment of bone infection

Wang

Zhu

Wang³

et al. 2023

Front. Bioeng. Biotechnol.

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The treatment of bone infections has always been difficult. The emergence of drug-resistant bacteria has led to a steady decline in the effectiveness of antibiotics. It is also especially important to fight bacterial infections while repairing bone defects and cleaning up dead bacteria to prevent biofilm formation. The development of biomedical materials has provided us with a research direction to address this issue. We aimed to review the current literature, and have summarized multifunctional antimicrobial materials that have long-lasting antimicrobial capabilities that promote angiogenesis, bone production, or “killing and releasing.” This review provides a comprehensive summary of the use of biomedical materials in the treatment of bone infections and a reference thereof, as well as encouragement to perform further research in this field.

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Vancomycin MIC and agr dysfunction in invasive MRSA infections in southern Brazil

et al. 2020

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Características moleculares de Staphylococcus aureus suscetível à vancomicina poderia ajudar a prever falhas no tratamento devido à reduzida suscetibilidade à vancomicina

Cited by 3 publications

References 12 publications

Resistance profile to antimicrobials agents in methicillin-resistant Staphylococcus aureus isolated from hospitals in South Brazil between 2014-2019

Resistance profile to antimicrobials agents in methicillin-resistant Staphylococcus aureus isolated from hospitals in South Brazil between 2014-2019

Implantable biomedical materials for treatment of bone infection

Vancomycin MIC and agr dysfunction in invasive MRSA infections in southern Brazil

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