Características E Incidência Do Tumor Venéreo Transmissível (Tvt) Em Cães E Eficiência Da Quimioterapia E Outros Tratamentos

Sousa, J.; Saito, Viviana García; Nardi, Andrígo Barboza De; Rodaski, S.; Guérios, S. D.; Bacila, Metry

doi:10.5380/avs.v5i1.3884

Cited by 27 publications

(43 citation statements)

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“…Spontaneous regression is documented in cases of experimental TVT, but the same is not routinely reported in clinical care . The tumour spontaneously regresses in healthy animals, and such regression is associated with the infiltration of lymphocytes and plasma cells as well as necrosis and apoptosis.…”

Section: Introductionmentioning

confidence: 99%

Cell cycle kinetics, apoptosis rates and gene expressions of MDR‐1, TP53, BCL‐2 and BAX in transmissible venereal tumour cells and their association with therapy response

Flórez

Fêo

Silva

et al. 2016

Vet Comparative Oncology

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Transmissible venereal tumour (TVT) generally presents different degrees of aggressiveness, which makes them unresponsive to conventional treatment protocols. This implies a progressive alteration of their biological profile. This study aimed to evaluate the cytotoxicity, cell survival, apoptosis and cell cycle alterations in TVT cell cultures subjected to treatment with vincristine. Similarly, it assessed possible implications of MDR-1, TP53, BCL-2, and BAX gene expressions in eight TVT primary cultures for both resistance to chemotherapy and biological behaviour. When comparing TVT cells receiving vincristine to those untreated, a statistical difference related to increased cytotoxicity and decreased survival rates, and alterations in G1 and S cell cycle phases were found but without detectable differences in apoptosis. Increased MDR-1 gene expression was observed after treatment. The groups did not differ statistically in relation to the TP53, BAX and BCL-2 genes. Although preliminary, the findings suggest that such augmented expression is related to tumour malignancy and chemotherapy resistance.

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Section: Introductionmentioning

confidence: 99%

Cell cycle kinetics, apoptosis rates and gene expressions of MDR‐1, TP53, BCL‐2 and BAX in transmissible venereal tumour cells and their association with therapy response

Flórez

Fêo

Silva

et al. 2016

Vet Comparative Oncology

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“…Como o caso relatado descreve um CCE na glândula lacrimal, parte importante para lubrificação e limpeza ocular, não foi instituída a excisão cirúrgica como tratamento, devido às complicações posteriores como ressecamento da córnea e possível desenvolvimento de úlcera, optando-se pelo tratamento de quimioterapia intralesional. A Vincristina é utilizada comumente na Medicina Veterinária como tratamento antineoplásico de tumores venéreos transmissíveis, com ação inibitória na divisão celular do tumor [1,32]. A literatura não descreve o potencial da Vincristina no tratamento de CCE, entretanto, Jaglan [14] relata um estudo com três grupos de animais, onde, o grupo II era composto de equinos com sarcóides benignos e o grupo III com sarcóides malignos.…”

Section: Discussionunclassified

Use of Vincristine Sulfate in the Treatment of Squamous Cell Carcinoma in a Horse's Lacrimal Gland

Jacobsen

Neto

Veiga

et al. 2019

Acta Scientiae. Vet.

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Background: Squamous cell carcinoma (SCC) is one of the most common cutaneous neoplasms found in equine breeding. The main cause is still unknown, based on predisposing factors such as excessive exposure to ultraviolet rays, advanced age, depigmented skin and viral or parasitic agents. There is currently a range of possibilities for the treatment of SCC. The choice of the ideal treatment changes according to the location, evolution and size of the tumor, economic costs and availability of material. The present case report aims to report the case of a Campeiro breed, diagnosed with SCC in the left lacrimal gland region and to evaluate the action of vincristine sulfate as intralesional chemotherapy. Case: A 30-year-old stallion of the Campeiro perlino coat it was attended in the sector of Clinic and Surgery of Large Animals, at the Federal University of Santa Catarina - Curitibanos campus. Physical examination revealed an alert and docile temperament, with no considerable physiological changes. In the evaluation of the left eye, it was observed a mass of 2x2 cm rosacea, with granular and ulcerated appearance, it was detected in the portion of the medial corner of the eye, and the lacrimal gland cannot be macroscopically delimited. Also it was detected a moderate mucopurulent secretion. The mass was collected through fine-needle aspiration (FNA) and puncture without aspiration of contents found in the third eyelid region for cytological analysis, and a malignant epithelial cell neoplasia associated with septic suppurative inflammation was observed, suggestive of SCC. After the laboratory results analyzed, 0.25 mL of intralesional vincristine sulfate (Vincizina®) with 20x06 needle was applied in the base of the tumor mass as treatment. After 24 days of the first and only application of the antineoplastic, treatment success was remarkable, with a macroscopic involution of the tumor area up to 80%. Discussion: The anatomical location of SCC covering the lacrimal gland, which is an important mechanism for ocular lubrication and cleaning, has prevented surgical excision from being instituted as an alternative treatment, due to subsequent complications such as corneal dryness and possible ulcer development. Therefore, intralesional chemotherapy became a safe and effective alternative to control and delay tumor mass, preserving the functions of the lacrimal gland. Vincristine is commonly used in veterinary medicine as an antineoplastic treatment of transmissible venereal tumors with inhibitory action on tumor cell division. Previous reports demonstrated success in the use of intravenous vincristine sulfate in the treatment of animals with benign and malignant sarcoids. In the present report satisfactory results were obtained, with only one application of intralesional vincristine sulfate, probably the continuity in the administration of the drug could have propitiated results with more effectiveness. By reason of the surgical excision, treatment of choice, not be feasible in this case, the use of a new form of treatment, less invasive and effective, aims to maintain the function of the affected organ and consequently in the welfare of animal. Every successfully treated animal should be monitored so that, in case of recurrence, it is re-treated as soon as possible.

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“…Sua disseminação ocorre por contato sexual e por meio de contato prolongado com superfícies contaminadas de outros animais (Sousa et al, 2000). O olho tem sido relatado como um local de ocorrência de TVT extragenital (Nayak e Samaddar, 1988;Mozos et al, 1996;Rodrigues et al, 2001;Pigatto et al, 2011).…”

Section: Introductionunclassified

“…Segundo Tinucci (2008) as metástases em locais extracutâneos são incomuns, correspondendo a cerca de 1% dos casos. As condutas terapêuticas mais utilizadas para tratamento do TVT são: criocirurgia, radioterapia, ressecção cirúrgica e quimioterapia (Andrade et al, 1999;Sousa et al, 2000). A excisão cirúrgica como única forma de tratamento * E mail: ivia@cca.ufpb.br pode ser eficaz em alguns animais (Ribeiro e Zappa, 2008) resultando em um controle em longo prazo (Hoque et al,1995).…”

Section: Introductionunclassified

34º Congresso Brasileiro da Associação Nacional de Clínicos Veterinários de Pequenos Animais - ANCLIVEPA

2013

AVB

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RESUMO -Objetiva-se relatar o caso de um cão, Rotweiller, de 11 anos de idade, atendido com sinais clínico-neurológicos progressivos devido à astrocitoma fibrilar medular multifocal. As imagens de mielografia indicaram desvio da coluna ventral do contraste entre as vértebras C6-C7. Após slot ventral para descompressão medular, houve alteração dos sinais clínicos sugerindo uma lesão no segmento medular C1-C5 que não foi visibilizada na mielografia. Devido ao prognóstico desfavorável optou-se pela eutanásia. Ao exame macroscópico foram identificados dois nódulos esbranquiçados bem delimitados na medula espinhal localizados em C1-C2 e em C7-C8. A avaliação histopatológica foi compatível com astrocitoma fibrilar.Palavras-chave: astrocitoma fibrilar, neoplasia medular, multifocal, cão.ABSTRACT -The purpose of this report is to describe a case of a 11 years old, entire male rotweiller dog presented for evaluation of progressive clinical neurological signs due to multifocal spinal cord fibrillary astrocytoma. Myelography imaging suggested ventral deviation of the constrast in the height between the sixth and the seventh cervical vertebrae. After performing ventral slot there were changes in the clinical signs suggesting a lesion in C1-C5 spinal cord segment there was not visualized in myelography. Euthanasia was performed due to the poor prognosis. Gross examination identified two well-defined whitish masses in the spinal cord, one located at C1-C2 and another on C7-C8. Histopatology was consistent with fibrillary astrocytoma.Key-words: fibrillary astrocytoma, spinal cord neoplasia, multifocal, dog INTRODUÇÃOAs neoplasias do sistema nervoso central podem ser subdivididas em primárias, originadas de células do tecido medular, meníngeo ou periespinhal, e secundárias ou metastáticas. Quando acometem a medula espinhal podem ser classificados como extradurais, intradurais/extramedulares ou intramedulares, sendo as extradurais as mais comuns (Bagley, 2010). As neoplasias intramedulares incluem os astrocitomas, oligodendrogliomas e ependimomas. Os tumores das células da glia são comuns na região encefálica e raramente atingem a medula espinhal (Maxie; Youssef, 2007). Acometem com maior frequência animais idosos, acima de cinco anos de idade, das raças Golden Retriever, Boxer, Doberman e Boston Terrier, não havendo predisposição por sexo (De Lahunta; Glass, 2009). Os astrocitomas podem ser classificados em três categorias de acordo com os subtipos celulares envolvidos: fibrilares, protoplasmáticos e gemistocíticos. (Cavaliere et al., 2005).O astrocitoma fibrilar é definido como tumor difuso de baixa malignidade caracterizado por alto grau * Email: mprajao@gmail.com de diferenciação celular, crescimento lento e infiltração difusa que resulta em prognóstico desfavorável aos animais (Malheiros et al., 1998). Ocorre com maior frequência como nódulo isolado no lobo piriforme, sendo raramente encontrado na medula espinhal e sob a forma multifocal (Cavalieire et al., 2005). Diante disso, objetiva-se relatar o caso de um cão com astr...

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Características E Incidência Do Tumor Venéreo Transmissível (Tvt) Em Cães E Eficiência Da Quimioterapia E Outros Tratamentos

Cited by 27 publications

References 4 publications

Cell cycle kinetics, apoptosis rates and gene expressions of MDR‐1, TP53, BCL‐2 and BAX in transmissible venereal tumour cells and their association with therapy response

Cell cycle kinetics, apoptosis rates and gene expressions of MDR‐1, TP53, BCL‐2 and BAX in transmissible venereal tumour cells and their association with therapy response

Use of Vincristine Sulfate in the Treatment of Squamous Cell Carcinoma in a Horse's Lacrimal Gland

34º Congresso Brasileiro da Associação Nacional de Clínicos Veterinários de Pequenos Animais - ANCLIVEPA

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