Características dos doadores de córneas do Banco de Olhos de Cascavel: impacto do exame anti-HBc para hepatite B

Abstract

Results: Mean age of donors was 54.2 ± 20.6 years and a greater proportion of men (64,7%) was observed. Mean time between death and enucleation was 3.8 ± 2.4 hours, cardiovascular diseases were the main cause of death (34.5%). Positivity of anti-HBc and HBsAg tests was 47.4% and 1.5%, respectively. Hepatitis B was the main reason for discarding corneas. Donors whose serologic tests were positive for anti-HBc had higher mean age compared to those with negative tests (p<0.001). Only 0.8% of all donations tested positive for hepatitis C and donors with positive HIV test were not seen in our study. Conclusions: Activities of the Cascavel Eye Bank significantly increased the availability of corneas for transplant in the State of Paraná. The main contraindication for availability of ocular tissues was positivity of serologic tests for anti-HBc. Biosafety studies should be performed in order to investigate the potential transmission of hepatitis B virus for donors with positive tests for anti-HBc. The inclusion of these donors would increase the number of corneas available for transplant.

Epidemiological profile of west center cornea donors

“…This etiological distribution demonstrates the importance of deaths by external causes, more frequent in another study and followed by circulatory diseases (9) . This data differs from others found in the literature, in which cardiovascular diseases are predominant as causes of death of the donors (1,6,10) . Maybe this divergence is due to the place where the uptakes are held.…”

“…However, we can explain this number of external causes with a gradual increase of deaths by car accidents in Goiás since 2006 (7) , with a higher incidence in males (7,8) . Analyzing donors by gender, there was a predominance of male donors, which is in agreement with other studies (6,9,10) . However, our sample was less accurate because other studies had a more homogeneous sample when comparing genders (6,9,10) .…”

“…Analyzing donors by gender, there was a predominance of male donors, which is in agreement with other studies (6,9,10) . However, our sample was less accurate because other studies had a more homogeneous sample when comparing genders (6,9,10) . This fact leads us to correlate the most important cause of death -external causes -to males due to greater risk of exposure to environmental factors associated to their work or social activity.…”

“…This fact is relevant due to the high economic impact that this specific population represents to the economy of a nation, leading to a loss of immeasurable value to society (13) . The average age of donors was 37.3 years, being lower than that found in other studies (6,9,10,(14)(15)(16) . We believe that it reflects a trend of large urban centers where youngsters are progressively more related to the various types of deaths associated with external causes, from crime to car accidents.…”

Characteristics of corneal donations in state of Piauí

“…The main cause of death were external causes (45.34%) followed by circulatory diseases (33.12%), in contrast with other studies that found cardiovascular diseases as the predominant cause of donor death 6,8,17 . The corneal quality of donors who died from external causes was generally better.…”