Características clínico-laboratoriais no retratamento por recidiva em hanseníase

Ferreira, Silvana Margarida Benevides; Ignotti, Eliane; Gamba, Mônica Antar

doi:10.1590/s1415-790x2012000300011

Cited by 9 publications

(20 citation statements)

References 25 publications

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“…In endemic areas, despite being a disease with a long incubation period, early contact of the child with the bacillus causes leprosy to develop in children between three to five years; a fact that added to poor sanitation conditions and the inadequacy of epidemiological surveillance and control, is considered a public health issue and exerts social, physical and psychological tolls in the pediatric population. 10 …”

Section: Epidemiologymentioning

confidence: 99%

“…Thus, the combination of high population density and precarious sanitation contributes to higher rates on the less favored regions of Brazil. 10 …”

Section: Epidemiologymentioning

confidence: 99%

“…5 In 1999, during the 3rd Regional Conference PAHO / WHO on leprosy elimination in the Americas held in Venezuela, Brazil signed the Declaration of Caracas, pledging to eliminate leprosy as a public health issue by 2005. 10 …”

Section: Epidemiologymentioning

confidence: 99%

“…There is a consensus in the literature that the diagnosis of leprosy in patients younger than fifteen years can be routinely used as an indicator of the level of transmission and severity of the endemy. 10,35 …”

Section: Epidemiologymentioning

confidence: 99%

“…Currently, with the notification of the disease in children under 15 years it appears that the contact is happening earlier. 7,10 …”

Section: Introductionmentioning

confidence: 99%

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Epidemiological situation of leprosy in Salvador from 2001 to 2009

Moreira

Batos²,

Tawil³

2014

An. Bras. Dermatol.

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Mycobacterium leprae was first described as the bacillus that causes leprosy, a chronic granulomatous infectious disease, in 1873 by Amauer Hansen. Leprosy is part of a group of 10 neglected diseases and Bahia has endemic levels of this illness, varying between high and very high. The detection of 52 new cases of leprosy in children under 15 years old in Salvador in 2006 is alarming, and suggests an early contact with the disease. The aim of this review is to analyze the epidemiological situation, the detection rate and evaluate the clinical and epidemiological profile of leprosy in Salvador, in the period 2001-2009. A retrospective cross-sectional study was performed using secondary data collected at Notifiable Diseases Information System Database (SINAN) through the notification of patients with leprosy. Over these nine years 3,226 patients were reported, with a predominance of: females (51.5%), and clinical multibacillary forms in the general population (51.7%), but when we analyze those under 15 years old, paucibacillary forms (tuberculoid + indeterminate) prevailed. The tuberculoid form was the most diagnosed type of presentation. The annual detection rate in Salvador remained at a very high level of endemicity during the studied period and for those under 15 years old it ranged between high and very high. Grade 2 disabilities both at the time of diagnosis and at discharge after cure, varied between low and medium. Based on these data we conclude that the high levels of leprosy detection rates in the general population, plus the variation between high and very high levels in those under 15 years old, associated with the medium level of grade 2 disabilities at the time of diagnosis and discharge, demonstrate the need for improvement on the existing services, investment in active case finding and training of the healthcare professionals in Salvador.

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Section: Epidemiologymentioning

confidence: 99%

“…Thus, the combination of high population density and precarious sanitation contributes to higher rates on the less favored regions of Brazil. 10 …”

Section: Epidemiologymentioning

confidence: 99%

Section: Epidemiologymentioning

confidence: 99%

Section: Epidemiologymentioning

confidence: 99%

“…Currently, with the notification of the disease in children under 15 years it appears that the contact is happening earlier. 7,10 …”

Section: Introductionmentioning

confidence: 99%

See 3 more Smart Citations

Epidemiological situation of leprosy in Salvador from 2001 to 2009

Moreira

Batos²,

Tawil³

2014

An. Bras. Dermatol.

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Leprosy Relapse After Polychemotherapy: A Systematic Review and Meta-Analysis

Verônica da Silva,

Santos de Sousa,

Ferreira

et al. 2023

Preprint

Self Cite

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Objective: To synthesize the best scientific evidence related to estimating the prevalence of leprosy relapse cases after polychemotherapy treatment.Method:A systematic review was conducted following the JBI methodology for systematic reviews of prevalence studies, and the reporting stage adhered to PRISMA-P, with registration No.: CRD42020177141. The inclusion criteria were adopted following the PopCoCo mnemonic (Population, Condition, Context). Population: people of both genders and any age, diagnosed with leprosy relapse, and treated with paucibacillary or multibacillary therapeutic regimes. Condition: leprosy relapse after Polychemotherapy (PCT) estimated as a proportion of cases.Context: studies conducted within the scope of health services. Databases used: Medline, LILACS, Embase, CINAHL, Scopus, WoS, CARPHA; Mendeley reference manager. A random-effects meta-analysis model was applied, and heterogeneity was assessed using the Higgins test.Results: Out of 41 studies included in the review, involving a total of 93,461 patients with leprosy, 4.09% (n=3,830) were eligible for relapse after polychemotherapy. Of them, 69.71% (n=2,670) were treated both with multibacillary and with paucibacillary regimes (72.36%, n=1,932; and 27.64%, n=738, respectively), and with a bacilloscopy index ≥4. Relapse prevalence was observed in males and in people aged over 30 years old. The meta-analysis estimated the global prevalence of leprosy relapse at 11% (95%CI: 0.09-0.12), with higher prevalence rates in Brazil (31%) and India (13%).Conclusion: There is evidence of high global prevalence of leprosy relapse after PCT, with higher estimates in India and Brazil, countries burdened with higher prevalence of the disease.SYNTHESISAlthough leprosy us an ancient disease with a scientifically proven effective treatment, it remains a Public Health problem. This is not only due to the disease high prevalence but also to its potential to cause physical disabilities, leading to emotional and social impacts and, consequently, compromising quality of life. In addition to the new cases of the disease, another concern commonly reported in the literature is leprosy relapse after polychemotherapy, as it has repercussions on therapeutic effectiveness. The relapse causes are usually associated with therapeutic failure due to incomplete treatment, misclassification in the initial treatment, and multidrug resistance. This study provides insights to verify the disease current prevalence based on scientific evidence, which can contribute to expanding the prevention strategies.

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Leprosy treatment dropout: a sistematic review

Girão¹,

Soares²,

Pinheiro³

et al. 2013

Int Arch Med

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BackgroundLeprosy is a chronic infectious disease endemic in some undeveloped areas, and still represents a public health problem in Brazil. Therefore, the control of this endemic disease depends necessarily on the institution of correct treatment and containment of treatment dropout. This study aims to conduct a systematic review of published studies on treatment dropout of leprosy.MethodsWe conducted a systematic review of articles on treatment dropout of leprosy, published between january 2005 and april 2013, on MEDLINE and SciELO databases. The search was performed using the MeSH terms: “leprosy”; “patients dropouts” and the keywords: “leprosy, treatment” and “noncompliance, leprosy” in association, beside the equivalents in Portuguese.ResultsThere were originally 196 references. After analyzing the titles and abstracts of articles, 20 articles were obtained and included in the final sample.DiscussionLeprosy is a notifiable disease known as its disfiguring capability and the high rate of non-compliance to treatment. The low adhesion is responsible for the remaining potential sources of infection, irreversible complications, incomplete cure and, additionally, may lead to resistance to multiple drugs. Many factors are responsible for the interruption or dropout treatment: socioeconomic factors, education level, knowledge about the disease, lack of efficiency of health services, demographics, side effects of drugs, alcoholism, among others.ConclusionThe recent scientific literature about the subject diverge regarding the factors that most affect the dropout problem in treating leprosy patients. However, better integration between professionals and users, and greater commitment of the patient, are common points among the authors of the studies.

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Características clínico-laboratoriais no retratamento por recidiva em hanseníase

Cited by 9 publications

References 25 publications

Epidemiological situation of leprosy in Salvador from 2001 to 2009

Epidemiological situation of leprosy in Salvador from 2001 to 2009

Leprosy Relapse After Polychemotherapy: A Systematic Review and Meta-Analysis

Leprosy treatment dropout: a sistematic review

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