Características clínicas de las crisis de asma de riesgo vital en los pacientes sensibilizados a Alternaria alternata

Plaza, Vicente; Serrano, J.; Picado, César; Cosano, Javier Rodero; Ancochea, Julio; Diego, A. De; Martín, Juan José; Sanchís, J.

doi:10.1016/s0025-7753(03)74076-7

Cited by 14 publications

(2 citation statements)

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“…Nearly 10% of near fatal asthma patients were reported to be sensitized to Alternaria and they were relatively young and less responsive to bronchodilator treatment. 7 In the present study, since we did not explored how sensitization to individual mold correlates with low lung function, we could not show the association of asthma severity with individual mold allergen. However, it is clear that sensitization to mold related to severity in asthma regardless of the species.…”

Section: Discussionmentioning

confidence: 59%

“… 4 5 6 Exposure to mold is strongly related to severe respiratory symptoms in patients with asthma, and sensitization has been described as a risk factor for life-threatening conditions. 7 8 Previous studies 7 9 have shown that sensitization to mold, particularly Alternaria , is linked to more persistence and severity of asthma. In a previous report, 8 20 of 37 (54%) patients admitted to the intensive care unit (ICU) for asthma and had positive skin test results to 1 or more mold allergens compared with 30% of patients not admitted to ICU.…”

Section: Introductionmentioning

confidence: 99%

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Association Between Sensitization to Mold and Impaired Pulmonary Function in Children With Asthma

Byeon

Amarsaikhan

et al. 2017

Allergy Asthma Immunol Res

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PurposeRecent data indicate that sensitization to mold contributes to the severity and persistence of asthma. In this study, we investigated the relationships between sensitization to mold and lung function parameters in children with asthma.MethodsWe retrospectively reviewed clinical data from 551 asthmatic subjects. We selected subjects who met clinical diagnostic criteria of asthma. Their spirometry, methacholine challenge tests, and measurements of blood eosinophils, serum IgE, eosinophil cationic protein (ECP) and fractional exhaled nitric oxide (FeNO) results were included. Skin prick testing (SPT) results with 13 common aeroallergens in Korea including house dust mites, animal dander, pollen, cockroach and mold were reviewed. Subjects were divided into 3 groups according to their SPT results. Subjects who showed no positive result to any aeroallergen were designated as group 1 (non-sensitized). Group 2 represented subjects who were sensitized to aeroallergens other than mold (other allergen-sensitized) and group 3 included subjects who were sensitized to mold allergens (mold-sensitized).ResultsAmong the 551 asthmatic subjects, 67 (12.2%) were sensitized to mold and 366 (66.4%) were sensitized to other aeroallergens. The log mean IgE levels were higher in groups 2 (5.96±1.14 IU/mL) and 3 (5.81±0.97 IU/mL) compared to group 1 (3.88±1.68 IU/mL). Blood eosinophils, ECP and FeNO concentrations were significantly higher in groups 2 and 3, but no significant difference was found between the 2 groups. The mean FEV1 value was significantly lower in group 3 (86.9±12.1%pred) than in groups 2 (92.0±14.8%pred) and 1 (93.4±15.4%pred). The log mean methacholine PC20 was significantly lower in group 3 (0.08±1.91 mg/mL) than in groups 2 (1.31±1.69 mg/mL) and 1 (2.29±1.66 mg/mL).ConclusionsWe observed a differential association between mold and other aeroallergen sensitization, and severity of asthma. Sensitization to mold is associated with lower lung function and increased airway hyper-responsiveness in children with asthma. Mold sensitization could be an important factor determining asthma severity particularly airflow limitation in children.

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Section: Discussionmentioning

confidence: 59%