CAR.CD123-NK Cells Have an Equally Effective but Safer Off-Tumor/on-Target Profile As Compared to CARCD123-T Cells for the Treatment of Acute Myeloid Leukaemia

Caruso, Simona; Quintarelli, Concetta; Angelis, Biagio De; Bufalo, Francesca Del; Ciccone, Roselia; Donsante, Samantha; Volpe, Gabriele; Manni, Simona; Guercio, Marika; Pezzella, Michele; Iaffaldano, Laura; Silvestris, Domenico Alessandro; Sinibaldi, Matilde; Cecca, Stefano Di; Pitisci, Angela; Velardi, Enrico; Merli, Pietro; Algeri, Mattia; Lodi, Mariachiara; Paganelli, Valeria; Serafini, M. Teresa; Riminucci, Mara; Locatelli, Franco

doi:10.1182/blood-2022-166107

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Car-nk Cell Therapy For Cancer1

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2023

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“…They infused human hematopoietic cells from UCB to immunodeficient mice that were treated with either CAR-T, CAR-NK, or unmodified T or NK cells 10 weeks after transplantation. The results reflected that all mice that received CAR-T cells infusion developed acute toxicity and died 5 days after treatment, while OS rate of other mice was 100 % at day 15 [ 86 ]. Significantly, high expression of inhibitory receptors on the surface of NK cells will also limit the clinical effects of therapy [ 87 ].…”

Section: Car-nk Cell Therapy For Cancermentioning

confidence: 99%

Current status and future perspective of natural killer cell therapy for cancer

Zhao,

Lin,

Huang

2023

Medical Review

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Natural killer (NK) cells possess innate abilities to effectively eliminate cancer cells. However, because of difficulties of proliferation and easy to be induced dysfunction in the setting of cancer post NK cell therapy, the curative effect of NK cell infusion has been constrained and not been widely applicable in clinical practice. The rapid development of biotechnology has promoted the development of NK cell therapy for cancer treatment. In this review, we will provide a comprehensive analysis of the current status and future prospects of NK cell therapy for cancer, focusing on the biological characteristics of NK cells, as well as strategies to enhance their targeting capabilities and overcome tumor immune suppression within the microenvironment.

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Section: Car-nk Cell Therapy For Cancermentioning

confidence: 99%