Current status and future perspective of natural killer cell therapy for cancer

Zhao, Xiangyu; Lin, Minghao; Huang, Xiaojun

doi:10.1515/mr-2023-0031

Cited by 2 publications

(1 citation statement)

References 113 publications

(128 reference statements)

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“…Alternatively, DNA electroporation offers a versatile platform to induce gene expression in NK cells. Recently, the development of genetic editing techniques such as the CRISPR/Cas9 system has opened new perspectives for precise genetic customisation [ 184 , 189 , 190 , 191 , 192 ].…”

Section: The Cancer Immunotherapy Strategiesmentioning

confidence: 99%

Contemporary Approaches to Immunotherapy of Solid Tumors

Kuznetsova,

Glukhova,

Popova

et al. 2024

Cancers

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In recent years, the arrival of the immunotherapy industry has introduced the possibility of providing transformative, durable, and potentially curative outcomes for various forms of malignancies. However, further research has shown that there are a number of issues that significantly reduce the effectiveness of immunotherapy, especially in solid tumors. First of all, these problems are related to the protective mechanisms of the tumor and its microenvironment. Currently, major efforts are focused on overcoming protective mechanisms by using different adoptive cell therapy variants and modifications of genetically engineered constructs. In addition, a complex workforce is required to develop and implement these treatments. To overcome these significant challenges, innovative strategies and approaches are necessary to engineer more powerful variations of immunotherapy with improved antitumor activity and decreased toxicity. In this review, we discuss recent innovations in immunotherapy aimed at improving clinical efficacy in solid tumors, as well as strategies to overcome the limitations of various immunotherapies.

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