Captopril in Human Blood and Breast Milk

Devlin, Richard G.; Fleiss, Paul M.

doi:10.1002/j.1552-4604.1981.tb01759.x

Cited by 87 publications

(23 citation statements)

References 6 publications

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“…The medical (45) subject headings used were ''antihypertensive agents,'' ''angiotensin-converting enzyme inhibitors,'' ''adrenergic beta-antagonists,'' ''calcium channel blockers,'' ''methyldopa,'' ''lactation,'' ''milk human,'' and ''breastfeeding.'' The search terms ''breast milk,'' ''breast milk,'' and ''breastfed'' were also used.…”

Section: Methodsmentioning

confidence: 99%

Excretion of Antihypertensive Medication Into Human Breast Milk: A Systematic Review

Beardmore

Morris

Gallery

2002

Hypertension in Pregnancy

139

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The available data to date indicate that ACE inhibitors, methyldopa, beta-blockers with high protein binding, and some calcium channel blockers all appear to be safe treatments of hypertension in a nursing mother. The data suggest that drugs to be avoided are beta-blockers with low protein binding. However, the available evidence is limited and further studies are needed to confirm these findings.

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Section: Methodsmentioning

confidence: 99%

Excretion of Antihypertensive Medication Into Human Breast Milk: A Systematic Review

Beardmore

Morris

Gallery

2002

Hypertension in Pregnancy

139

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“…aztreonam, captopril, diltiazem and (Fehrenbach, 1987). tinidazole (Devlin & Fleiss, 1981;Evaldson et Maternal antimicrobials are often required in Fleiss et al, 1985;Okada et al, 1985). the postnatal period and a prescribing survey in These studies have concentrated on drug kinetics Northern Ireland showed that 4% of puerperal and while this is a very important aspect, previous mothers received metronidazole therapy (Passstudies have given little information about infant more et al, 1983).…”

Section: Introductionmentioning

confidence: 99%

Metronidazole excretion in human milk and its effect on the suckling neonate.

Passmore

McElnay

Rainey

et al. 1988

Brit J Clinical Pharma

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1. Milk and plasma metronidazole and hydroxymetronidazole concentrations were measured in 12 breast‐feeding patients following multiple doses of metronidazole (400 mg three times daily). All patients received metronidazole in combination with other broad spectrum antibiotics. 2. Plasma concentrations of both parent drug and metabolite were measured in seven suckling infants. Thirty‐five infants were monitored for adverse reactions to maternal metronidazole therapy and two further groups of suckling infants, those whose mothers received either ampicillin alone or no drug therapy, were recruited as controls. 3. The mean milk to plasma ratio (M/P) was 0.9 for metronidazole and 0.76 for hydroxymetronidazole while the mean milk metronidazole concentrations (around Cmax) were 15.5 micrograms ml‐1. The mean milk hydroxymetronidazole concentration was 5.7 micrograms ml‐ 1. 4. Infant plasma metronidazole concentrations ranged from 1.27 micrograms ml‐1 to 2.41 micrograms ml‐1, and the corresponding hydroxymetronidazole concentrations from 1.1 to 2.4 micrograms ml‐1. 5. There were no significant increases in adverse effects in infants which could be attributable to maternal metronidazole therapy. 6. Metronidazole was excreted in milk at concentrations which caused no serious reactions in the infants studied. The drug may therefore be administered at doses of 400 mg three times daily to mothers wishing to breast‐feed their infants.

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“…The peak milk level is about 1 % of the peak plasma concentration, while average milk levels over 12 h following a dose is about 3 % of the average serum levels. Based on this information, the maximum daily dosage in milk is less than 0.014 % of the maternal weight-adjusted daily dose (Devlin and Fleiss 1981;Redman et al 1990). There have been no observed adverse effects in breastfed infants (Devlin and Fleiss 1981;Huttunen et al 1989;Rush et al 1989).…”

Section: Ace-i and Breastfeedingmentioning

confidence: 99%