Capsaicin receptor TRPV1 maintains quiescence of hepatic stellate cells in the liver via recruitment of SARM1

Le, Tao; Yang, Guangyue; Sun, Tiantian; Tao, Jie; Zhu, Chan; Yu, Huimin; Cheng, Yefei; Yang, Zongguo; Xu, Ming-Yi; Jiang, Yuefeng; Zhang, Wei; Wang, Zhiyi; Ma, Wenting; Wu, Lu; Xue, Dongying; Wang, Dongxue; Yang, Wentao; Zhao, Yi; Horsefield, S.; Kobe, Boštjan; Zhang, Zhe; Tang, Zongxiang; Li, Qigen; Zhai, Qiwei; Dooley, Steven; Seki, Ekihiro; Liu, Ping; Xu, Jianrong; Chen, Hong‐Zhuan; Liu, Cheng

doi:10.1016/j.jhep.2022.12.031

Cited by 8 publications

(1 citation statement)

References 32 publications

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“…( Tables 1 , 2 ). In addition, with the development of novel experimental approaches such as cryo-electron microscopy (cryo-EM) ( Zhang et al, 2021 ; Yelshanskaya and Sobolevsky, 2022 ), bioluminescence resonance energy transfer (BRET), and NanoBiT, ( Tao et al, 2023 ) etc., great achievements have been made recently, especially in pharmaceutical studies. For example, cryo-EM technology made it possible to resolve the complex structure of channels/GPCRs and their ligands small molecules and protein-binding partners, leading to a large number of discoveries of agonists or inhibitors specific to proton-sensing channels, and a rapid development of potential anti-cancer drugs ( Moraes, 1973 ; Yelshanskaya and Sobolevsky, 2022 ).…”

Section: Introductionmentioning

confidence: 99%

Proton-sensing ion channels, GPCRs and calcium signaling regulated by them: implications for cancer

Ji,

Chang,

et al. 2024

Front. Cell Dev. Biol.

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Extracellular acidification of tumors is common. Through proton-sensing ion channels or proton-sensing G protein-coupled receptors (GPCRs), tumor cells sense extracellular acidification to stimulate a variety of intracellular signaling pathways including the calcium signaling, which consequently exerts global impacts on tumor cells. Proton-sensing ion channels, and proton-sensing GPCRs have natural advantages as drug targets of anticancer therapy. However, they and the calcium signaling regulated by them attracted limited attention as potential targets of anticancer drugs. In the present review, we discuss the progress in studies on proton-sensing ion channels, and proton-sensing GPCRs, especially emphasizing the effects of calcium signaling activated by them on the characteristics of tumors, including proliferation, migration, invasion, metastasis, drug resistance, angiogenesis. In addition, we review the drugs targeting proton-sensing channels or GPCRs that are currently in clinical trials, as well as the relevant potential drugs for cancer treatments, and discuss their future prospects. The present review aims to elucidate the important role of proton-sensing ion channels, GPCRs and calcium signaling regulated by them in cancer initiation and development. This review will promote the development of drugs targeting proton-sensing channels or GPCRs for cancer treatments, effectively taking their unique advantage as anti-cancer drug targets.

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