Proton-sensing ion channels, GPCRs and calcium signaling regulated by them: implications for cancer
Renhui Ji,
Li Chang,
Caiyan An
et al.
Abstract:Extracellular acidification of tumors is common. Through proton-sensing ion channels or proton-sensing G protein-coupled receptors (GPCRs), tumor cells sense extracellular acidification to stimulate a variety of intracellular signaling pathways including the calcium signaling, which consequently exerts global impacts on tumor cells. Proton-sensing ion channels, and proton-sensing GPCRs have natural advantages as drug targets of anticancer therapy. However, they and the calcium signaling regulated by them attra… Show more
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