Capsaicin-loaded folic acid-conjugated lipid nanoparticles for enhanced therapeutic efficacy in ovarian cancers

Lv, Lin; Zhuang, Yuxin; Zhang, Hui-wu; Tian, Nannan; Dang, Wen-Zhen; Wu, Shaoyu

doi:10.1016/j.biopha.2017.04.097

Cited by 34 publications

(13 citation statements)

References 20 publications

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“…In other study by Lv et al (), the capsaicin (CAP), as apoptosis inducer that could be instigate the intrinsic mitochondrial pathway and extrinsic death receptor pathways through caspase cascade in cancer cells, was loaded in 1,2‐distearoyl‐ sn ‐glycero‐3‐phosphoethanolamine‐ N ‐[methoxy (polyethylene glycol)‐2000] (DSPE‐PEG) FA‐based lipid NP (with size 108.5 nm in diameter) as novel DDS. CAP with an increase in the p21 and decrease in cyclin E level, induce the cell cycle arrest, and cell death in G0/G1 phase of cell cycle.…”

Section: Lipid‐based Nps In Drug Deliverymentioning

confidence: 99%

Folic acid functionalized nanoparticles as pharmaceutical carriers in drug delivery systems

Narmani

Rezvani

Farhood

et al. 2019

Drug Development Research

152

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Conventional chemotherapeutic approaches in cancer therapy such as surgery, chemotherapy, and radiotherapy have several disadvantages due to their nontargeted distributions in the whole body. On the other hand, nanoparticles (NPs) based therapies are remarkably progressing to solve several limitations of conventional drug delivery systems (DDSs) including nonspecific biodistribution and targeting, poor water solubility, weak bioavailability and biodegradability, low pharmacokinetic properties, and so forth. The enhanced permeability and retention effect escape from Pglycoprotein trap in cancer cells as a passive targeting mechanism, and active targeting strategies are also other most important advantages of NPs in cancer diagnosis and therapy. Folic acid (FA) is one of the biologic molecules which has been targeted overexpressed-folic acid receptor (FR) on the surface of cancer cells. Therefore, conjugation of FA to NPs most easily enhances the FR-mediated targeting delivery of therapeutic agents. Here, the recent works in FA which have been decorated NPs-based DDSs are discussed and cancer therapy potency of these NPs in clinical trials are presented. K E Y W O R D Scancer diagnosis and therapy, folic acid, nanoparticles, nanotechnology, targeted drug delivery

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Section: Lipid‐based Nps In Drug Deliverymentioning

confidence: 99%

Folic acid functionalized nanoparticles as pharmaceutical carriers in drug delivery systems

Narmani

Rezvani

Farhood

et al. 2019

Drug Development Research

152

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“…Capsaicin, the best-known TRPV1 agonist, stimulates apoptosis in pancreatic, urothelial, and renal cancer cells, and gliomas. In the case of ovarian cancer, one study has demonstrated the apoptosis-inducing effect of capsaicin using fatty-acid-conjugated lipid nanoparticles [ 35 ]. Furthermore, capsaicin reportedly inhibits the metastasis of thyroid cancer [ 32 ].…”

Section: Discussionmentioning

confidence: 99%

TRPV1 Antagonist DWP05195 Induces ER Stress-Dependent Apoptosis through the ROS-p38-CHOP Pathway in Human Ovarian Cancer Cells

Wang

Lee

Lim

et al. 2020

Cancers

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In addition to their analgesic activity, transient receptor potential vanilloid 1 (TRPV1) agonists and antagonists demonstrate profound anti-cancer activities in various human cancers. In the present study, we investigated the anti-cancer activity of a novel TRPV1 antagonist, DWP05195, and evaluated its molecular mechanism in human ovarian cancer cells. DWP05195 demonstrated potent growth inhibitory effects in all five ovarian cancer cell lines examined. DWP05195 induced apoptosis through the activation of caspase-3, -8, and -9. DWP05195 induced C/EBP homologous protein (CHOP) expression and endoplasmic reticulum (ER) stress. Sodium phenylbutyrate (4-PBA), an ER-stress inhibitor, and CHOP knockdown significantly suppressed DWP5195-induced cell death. DWP05195-enhanced CHOP expression stimulated intrinsic and extrinsic apoptotic pathways through the regulation of Bcl2-like11 (BIM), death receptor 4 (DR4), and DR5. DWP05195-induced cell death was associated with increased reactive oxygen species (ROS) levels and p38 pathway activation. Pre-treatment with the antioxidant N-acetyl-L-cysteine (NAC) significantly suppressed DWP05195-induced CHOP expression and p38 activation. Inhibition of NADPH oxidase (NOX) through p47phox knockdown abolished DWP05195-induced CHOP expression and cell death. Taken together, the findings indicate that DWP05195 induces ER stress-induced apoptosis via the ROS-p38-CHOP pathway in human ovarian cancer cells.

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“…24 Recently, CAP-loaded nanoparticles (NPs) have been developed to prolong the drug retention of CAP in the blood circulation and allow active targeting of specific cancer cells for enhanced, precise delivery and target specificity, which may provide a very promising approach to chemotherapy for malignant tumours. [24][25][26][27] This review critically discusses the anti-cancer properties of CAP and potential molecular mechanisms (Table 1), chemo-radiosensitization, the application of CAP-loaded NPs and the mechanisms behind it. Also, some suggestions and prospects for future research have been provided.…”

Section: What Is K Nown and Objec Tivementioning

confidence: 99%

Application of capsaicin as a potential new therapeutic drug in human cancers

et al. 2019

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What is known and objective: Capsaicin, the major active ingredient of chili pepper, may play a "dual role" in tumourigenesis, acting as a carcinogen or as a cancer preventive agent. The aim of this study was to investigate the anticancer mechanisms of capsaicin and the effects of capsaicin on traditional chemotherapeutic drugs and radiotherapy in various cancer types and the potential for clinical application in cancer therapy. Methods: We conducted extensive literature searches through PubMed to collect representative studies of capsaicin in different cancer types. These studies investigated the anticancer molecular mechanisms of capsaicin.

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Capsaicin-loaded folic acid-conjugated lipid nanoparticles for enhanced therapeutic efficacy in ovarian cancers

Cited by 34 publications

References 20 publications

Folic acid functionalized nanoparticles as pharmaceutical carriers in drug delivery systems

Folic acid functionalized nanoparticles as pharmaceutical carriers in drug delivery systems

TRPV1 Antagonist DWP05195 Induces ER Stress-Dependent Apoptosis through the ROS-p38-CHOP Pathway in Human Ovarian Cancer Cells

Application of capsaicin as a potential new therapeutic drug in human cancers

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