Capsaicin induces a protective effect on gastric mucosa along with decreased expression of inflammatory molecules in a gastritis model

Mendivil, Edgar J.; Sandoval-Rodríguez, Ana; Meza-Ríos, Alejandra; Zuñiga-Ramos, Lourdes M.; Dominguez-Rosales, Alfredo; Mercado, Mónica Vázquez-Del; Sánchez-Orozco, Laura V.; Santos, Arturo; Armendáriz‐Borunda, Juan

doi:10.1016/j.jff.2019.06.002

Cited by 18 publications

(12 citation statements)

References 31 publications

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“…Moreover, the capsaicin in NCE could potentially increase immune response via decreasing pro-inflammatory cytokines, including TNF-α and IL-1β ( Spiller et al., 2008 ). Previous study has demonstrated that capsaicin in NCE could alleviate inflammatory response via reducing the gene expression of TNF-α, IL-1β, and IL-6 ( Mendivil et al., 2019 ). Moreover, the capsaicin in NCE could also modulate the release of some inflammatory cytokines (such as IL-10, TNF-α, IL-1β, IL-6, IL-12) through the down-regulation of NF-ĸB pathway ( Zhou et al., 2014 ).…”

Section: Discussionmentioning

confidence: 99%

Natural capsicum extract replacing chlortetracycline enhances performance via improving digestive enzyme activities, antioxidant capacity, anti-inflammatory function, and gut health in weaned pigs

2021

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The objective of this study was to investigate the effects of natural capsicum extract (NCE, containing 2% natural capsaicin, the rest is carrier) replacing chlortetracycline (CTC) on performance, digestive enzyme activities, antioxidant capacity, inflammatory cytokines, and gut health in weaned pigs. A total of 108 weaned pigs (Duroc × [Landrace × Yorkshire], initial body weight = 8.68 ± 1.34 kg; weaned on d 28) were randomly allotted into 3 treatments with 6 replicate pens per treatment (3 barrows and 3 gilts per pen). The treatments include a corn-soybean meal basal diet as a control group (CON), a CTC group (basal diet + CTC at 75 mg/kg), and a NCE group (basal diet + NEC at 80 mg/kg). Compared with CON and CTC, NCE had increased ( P < 0.05) average daily gain in phase 2 (d 15 to 28) and overall (d 1 to 28), and higher ( P < 0.05) apparent total tract digestibility of gross energy, dry matter, crude protein, and organic matter in phase 1 (d 1 to 14). These pigs also had increased ( P < 0.05) pancrelipase activity in pancreas, α-amylase, lipase and protease activities in the jejunal mucosa, and lipase activity in the ileal mucosa on d 28. Moreover, NCE had increased ( P < 0.05) the contents of growth hormone, β-endorphin, 5-hydroxytryptamine, total antioxidant capacity, total superoxide dismutase, catalase, and IL-10, as well as decreased ( P < 0.05) contents of malondialdehyde, tumor nuclear factor-α, interferon-γ, and interleukin-6 in serum on d 28 compared with CON and CTC. NCE showed higher ( P < 0.05) propionic acid, butyric acid and total volatile fatty acids (VFA) contents, and increased ( P < 0.05) relative abundance of Faecalibacterium in colon, as well as higher ( P < 0.05) propionic acid and total volatile fatty acids in cecum on d 28 compared with CON. In conclusion, NCE replacing CTC could enhance performance via improving digestive enzyme activities, antioxidant capacity, anti-inflammatory function, gut VFA composition and microbiota community in weaned pigs, and it could be used as a potential target for the development of feed additives.

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Section: Discussionmentioning

confidence: 99%

Natural capsicum extract replacing chlortetracycline enhances performance via improving digestive enzyme activities, antioxidant capacity, anti-inflammatory function, and gut health in weaned pigs

2021

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“…The explanation is low doses of capsaicin improve gastric blood flow to the mucosa, increase submucosal blood perfusion, and consequently minimize mucosal lesions produced by ethanol [28] . Capsaicin provide protection to gastric mucosa through suppression of proinflammatory cytokines [29] . Different mechanisms were suggested for the protective effect of small doses (100-800 µg/kg) of capsaicin.…”

Section: Discussionmentioning

confidence: 99%

Possible Protective Effect of Capsaicin against Indomethacin-induced damage in Jejunum of adult male albino rats (Histological and Histochemical study)

Shaalan

Arafat

Naim

et al. 2020

Journal of Medical Histology

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Background and Objectives: Indomethacin is widely used in treatment of many rheumatic conditions. This use is limited by its damaging effect on gastrointestinal mucosa. Capsaicin is the main pungent and active principal ingredient in hot chili peppers. It has been used widely in the field of medicine. This study aimed to evaluate the protective effect of capsaicin against indomethacin-induced jejunal damage. Materials and Methods: Seventy adult male albino rats, used in this study, were divided equally into 7 groups. Group I (control) received distilled water. Group II received the solvent of capsaicin. Group III received 15 mg/kg BW of indomethacin. Group IV received low dose of capsaicin prior to indomethacin. Group V received high dose of capsaicin prior to indomethacin. Group VI received low dose of capsaicin. Group VII received high dose of capsaicin. All solutions were given intragastrically. All animals were sacrificed 24 hours after ingestion of solutions. Jejunal specimens were processed to perform histological (H&E and Masson's trichrome) and histochemical stains (combined alcian blue and PAS) and were examined under light microscope. Results: Giving indomethacin caused: decrease in the height of villi and thickening of the brush border, increase in width of villi and mitotic index of crypt cells, haemorrhage, and inflammatory cellular infiltration. Ingestion of low dose of capsaicin prior to indomethacin prevented the effect of indomethacin on jejunal mucosa more than high dose. Conclusion: Giving low dose of capsaicin prior to indomethacin prevented the effects of indomethacin but high dose did not produce the same effect.

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“…At doses of 300 and 600 mg/kg body weight, the aqueous extract of the chili pepper ( C. frutescens ) reduced the gastric ulcer length of aspirin-induced ulcer in experimental rats, which proved the curing properties of the extract of C. frutescen [ 159 ]. Capsaicin (molecular formula: C 18 H 27 NO 3 ) ( Figure 1 ) is the major bioactive component of these plants, exhibits anti-inflammatory characteristics [ 160 , 161 ]. This secondary metabolite of Capsicum spp.…”

Section: Plant Mediated Treatment Of Ulcer and Inflammatory Diseasesmentioning

confidence: 99%

“…Researchers assessed the impact of capsaicin on the mucosa of the stomach, pro-inflammatory cytokines (e.g., TNF-α, IL-6, IL-1β), and COX-2 in gastric mucosa in two experimental models. Histopathological examinations coupled with molecular studies of stomach samples revealed a protective action of gastric mucosa along with a substantial reduction of pro-inflammatory cytokines as well as COX-2 in both experimental models [ 160 ].…”

Section: Plant Mediated Treatment Of Ulcer and Inflammatory Diseasesmentioning

confidence: 99%

Therapeutic Promises of Medicinal Plants in Bangladesh and Their Bioactive Compounds against Ulcers and Inflammatory Diseases

Ahmed

Rabbee

Roy

et al. 2021

Plants

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When functioning properly, the stomach is the center of both physical and mental satisfaction. Gastrointestinal disorders, or malfunctioning of the stomach, due to infections caused by various biological entities and physiochemical abnormalities, are now widespread, with most of the diseases being inflammatory, which, depending on the position and degree of inflammation, have different names such as peptic or gastric ulcers, irritable bowel diseases, ulcerative colitis, and so on. While many synthetic drugs, such as non-steroidal anti-inflammatory drugs, are now extensively used to treat these diseases, their harmful and long-term side effects cannot be ignored. To treat these diseases safely and successfully, different potent medicinal plants and their active components are considered game-changers. In consideration of this, the present review aimed to reveal a general and comprehensive updated overview of the anti-ulcer and anti-inflammatory activities of medicinal plants. To emphasize the efficacy of the medicinal plants, various bioactive compounds from the plant extract, their experimental animal models, and clinical trials are depicted.

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Capsaicin induces a protective effect on gastric mucosa along with decreased expression of inflammatory molecules in a gastritis model

Cited by 18 publications

References 31 publications

Natural capsicum extract replacing chlortetracycline enhances performance via improving digestive enzyme activities, antioxidant capacity, anti-inflammatory function, and gut health in weaned pigs

Natural capsicum extract replacing chlortetracycline enhances performance via improving digestive enzyme activities, antioxidant capacity, anti-inflammatory function, and gut health in weaned pigs

Possible Protective Effect of Capsaicin against Indomethacin-induced damage in Jejunum of adult male albino rats (Histological and Histochemical study)

Therapeutic Promises of Medicinal Plants in Bangladesh and Their Bioactive Compounds against Ulcers and Inflammatory Diseases

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