Capsaicin effects on brain-derived neurotrophic factor in rat dorsal root ganglia and spinal cord

Ha, Sun-Ok; Yoo, Hea-Jin; Park, So-Yun; Hong, Hae-Sook; Kim, Dong–Sun; Cho, Hee-Jung

doi:10.1016/s0169-328x(00)00144-3

Cited by 8 publications

(5 citation statements)

References 40 publications

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“…Next, we asked whether the d4T‐induced mechanical allodynia and increased neuronal activity in the SDH might involve altered levels of BDNF in the SDH, because previous studies have shown that BDNF levels increase in the SDH following peripheral inflammation (Cho et al,1997; Mannion et al,1999; Ha et al,2000) and various peripheral nerve injuries (Cho et al,1998; Miletic and Miletic,2002; Yajima et al,2002, 2005). Mice were given a single i.v.…”

Section: Resultsmentioning

confidence: 99%

Brain‐derived neurotrophic factor modulates antiretroviral‐induced mechanical allodynia in the mouse

Renn

Leitch

Lessans

et al. 2011

J of Neuroscience Research

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Nucleoside reverse transcriptase inhibitors (NRTIs) are key components of HIV/AIDS treatment to reduce viral load. However, these drugs can induce chronic neuropathic pain, leading to increased morbidity in HIV patients. This study examines the role of brain-derived neurotrophic factor (BDNF) in the spinal dorsal horn (SDH) in development of mechanical allodynia in male C57BL/6J mice treated with the NRTI stavudine (d4T). After d4T administration, mice developed increased neuronal activity and BDNF expression in the SDH and hind paw mechanical allodynia that was exacerbated by intrathecal BDNF administration. Intrathecal BDNF alone also increased neuronal activity and caused mechanical allodynia. Because excess BDNF amplified d4T-induced mechanical allodynia and neuronal activity, the impact of decreasing BDNF in the SDH was investigated. After d4T, BDNF heterozygous mice were less allodynic than wild-type littermates, which was negated by intrathecal BDNF administration. Finally, pretreatment with intrathecal trkB-Fc chimera prior to d4T or administration of the tyrosine kinase inhibitor K252a 3 days after d4T blocked BDNF-mediated signaling, significantly attenuated the development of mechanical allodynia (trkB-Fc), and decreased neuronal activity (trkB-Fc and K252a). Taken together, these findings provide evidence that BDNF in the SDH contributes to the development of NRTI-induced painful peripheral neuropathy and may represent a new therapeutic opportunity.

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Section: Resultsmentioning

confidence: 99%

Brain‐derived neurotrophic factor modulates antiretroviral‐induced mechanical allodynia in the mouse

Renn

Leitch

Lessans

et al. 2011

J of Neuroscience Research

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“…A study suggested that red peppers with moderate and severe pungency prevent memory deficit in rats [34]. In adult rats, capsaicin administration was associated with an initial increase in BDNF levels, within 1–3 days, followed by a decrease in BDNF after 4 weeks [35]. BDNF is important for neuronal survival, growth, and differentiation, and has an important role in learning memory [36].…”

Section: Discussionmentioning

confidence: 99%

High Chili Intake and Cognitive Function among 4582 Adults: An Open Cohort Study over 15 Years

et al. 2019

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We aimed to examine the association between chili intake and cognitive function in Chinese adults. This is a longitudinal study of 4852 adults (age 63.4 ± 7.7) attending the China Health and Nutrition Survey during 1991 and 2006. Cognitive function was assessed in 1997, 2000, 2004 and 2006. In total, 3302 completed cognitive screening tests in at least two surveys. Chili intake was assessed by a 3-day food record during home visits in each survey between 1991 and 2006. Multivariable mixed linear regression and logistic regression were used. Chili intake was inversely related to cognitive function. In fully adjusted models, including sociodemographic and lifestyle factors, compared with non-consumers, those whose cumulative average chili intake above 50 g/day had the regression coefficients (and 95% CI) for global cognitive function of −1.13 (−1.71–0.54). Compared with non-consumers, those with chili consumption above 50 g/day had the odds ratio (and 95% CI) of 2.12(1.63–2.77), 1.56(1.23–1.97) for self-reported poor memory and self-reported memory decline, respectively. The positive association between chili intake and cognitive decline was stronger among those with low BMI than those with high BMI. The longitudinal data indicate that higher chili intake is positively associated with cognitive decline in Chinese adults in both genders.

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“…Although the neuron size is dependent on the age or the body size of the rat, these neurons were classified as medium–large [29]–[31]. On the other hand, the nociceptive neurons that expressed either CGRP or P2X 3 were mostly small.…”

Section: Discussionmentioning

confidence: 99%

Light-evoked Somatosensory Perception of Transgenic Rats That Express Channelrhodopsin-2 in Dorsal Root Ganglion Cells

Honjoh

et al. 2012

PLoS ONE

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In vertebrate somatosensory systems, each mode of touch-pressure, temperature or pain is sensed by sensory endings of different dorsal root ganglion (DRG) neurons, which conducted to the specific cortical loci as nerve impulses. Therefore, direct electrical stimulation of the peripheral nerve endings causes an erroneous sensation to be conducted by the nerve. We have recently generated several transgenic lines of rat in which channelrhodopsin-2 (ChR2) transgene is driven by the Thy-1.2 promoter. In one of them, W-TChR2V4, some neurons were endowed with photosensitivity by the introduction of the ChR2 gene, coding an algal photoreceptor molecule. The DRG neurons expressing ChR2 were immunohistochemically identified using specific antibodies to the markers of mechanoreceptive or nociceptive neurons. Their peripheral nerve endings in the plantar skin as well as the central endings in the spinal cord were also examined. We identified that ChR2 is expressed in a certain population of large neurons in the DRG of W-TChR2V4. On the basis of their morphology and molecular markers, these neurons were classified as mechanoreceptive but not nociceptive. ChR2 was also distributed in their peripheral sensory nerve endings, some of which were closely associated with CK20-positive cells to form Merkel cell-neurite complexes or with S-100-positive cells to form structures like Meissner's corpuscles. These nerve endings are thus suggested to be involved in the sensing of touch. Each W-TChR2V4 rat showed a sensory-evoked behavior in response to blue LED flashes on the plantar skin. It is thus suggested that each rat acquired an unusual sensory modality of sensing blue light through the skin as touch-pressure. This light-evoked somatosensory perception should facilitate study of how the complex tactile sense emerges in the brain.

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Capsaicin effects on brain-derived neurotrophic factor in rat dorsal root ganglia and spinal cord

Cited by 8 publications

References 40 publications

Brain‐derived neurotrophic factor modulates antiretroviral‐induced mechanical allodynia in the mouse

Brain‐derived neurotrophic factor modulates antiretroviral‐induced mechanical allodynia in the mouse

High Chili Intake and Cognitive Function among 4582 Adults: An Open Cohort Study over 15 Years

Light-evoked Somatosensory Perception of Transgenic Rats That Express Channelrhodopsin-2 in Dorsal Root Ganglion Cells

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