Capnocytophaga Keratitis

Pamel, Gregory; Buckley, Daniel J.; Frucht, J; Krausz, Howard I.; Feldman, Sandy T.

doi:10.1016/0002-9394(89)90226-2

Cited by 7 publications

(4 citation statements)

References 4 publications

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“…In our case, a Capnocytophaga species was isolated and identified as the causative agent of keratitis in association with CLs. Capnocytophaga keratitis H. Iimori and others has been reported in several studies (Alexandrakis et al, 2000;Chodosh, 2001;Font et al, 1994;Heidemann et al, 1988;Pamel et al, 1989;Roussel et al, 1985;Ticho et al, 1990). Alexandrakis et al reported 10 cases of Capnocytophaga keratitis and reviewed 14 cases from the literature.…”

Section: Discussionmentioning

confidence: 90%

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A case of contact‐lens‐related keratitis caused by fluoroquinolone‐ and tobramycin‐resistant Capnocytophaga sputigena

et al. 2015

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Introduction: Capnocytophaga species are rare keratitis-causing pathogens. We herein report a case of keratitis caused by a drug-resistant Capnocytophaga species in association with contact lenses.Case presentation: A 64-year-old female who wore a contact lens in her right eye to facilitate repair of the corneal epithelium complained of infection and discharge. Slit-lamp biomicroscopy showed corneal abscessation and hypopyon. Thus, infectious keratitis was diagnosed. Direct microscopy and bacterial culture of a corneal scraping were performed. Because direct microscopy demonstrated the presence of Gram-negative rods, we began treatment with topical 1.5 % levofloxacin and 0.3 % tobramycin every hour. The corneal infiltration increased 4 days after initiating the therapy. The culture report confirmed the presence of a Capnocytophaga species with fluoroquinolone and aminoglycoside resistance and susceptibility to cephalosporins and minocycline. We switched to topical 0.5 % cefmenoxime every hour and oral minocycline at 200 mg day 21. The corneal inflammation subsided within 2 weeks. The bacterial isolate was identified as Capnocytophaga sputigena using 16S rRNA sequencing. Conclusions:We encountered a case of keratitis caused by C. sputigena with reduced fluoroquinolone and aminoglycoside susceptibility.

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Section: Discussionmentioning

confidence: 90%

“…These species rarely cause keratitis (Alexandrakis et al, 2000;Chodosh, 2001;Font et al, 1994;Heidemann et al, 1988;Pamel et al, 1989;Roussel et al, 1985;Ticho et al, 1990). Capnocytophaga isolates are susceptible to most groups of antibiotics (Jolivet-Gougeon et al, 2007).…”

Section: Introductionmentioning

confidence: 99%

A case of contact‐lens‐related keratitis caused by fluoroquinolone‐ and tobramycin‐resistant Capnocytophaga sputigena

et al. 2015

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“…Capnocytophaga keratitis in human patients is an uncommon infection associated with an aggressive clinical nature and generally poor outcome . In one large case series of Capnocytophaga keratitis patients, 50% of affected eyes required enucleation for corneal perforation, progression to endophthalmitis, or vision loss with uncontrollable pain.…”

Section: Discussionmentioning

confidence: 99%

“…Capnocytophaga infection of the human cornea appears to most commonly be acquired from human microflora sources as, when the bacterial species was reported, most isolates belonged to the group associated with the human oral cavity . There are also occasional descriptions of human Capnocytophaga keratitis occurring secondary to traumatic injury with canine and feline teeth or claws and associated with Capnocytophaga canimorsus infection .…”

Section: Discussionmentioning

confidence: 99%