A case of contact‐lens‐related keratitis caused by fluoroquinolone‐ and tobramycin‐resistant Capnocytophaga sputigena

Abstract

Introduction: Capnocytophaga species are rare keratitis-causing pathogens. We herein report a case of keratitis caused by a drug-resistant Capnocytophaga species in association with contact lenses.Case presentation: A 64-year-old female who wore a contact lens in her right eye to facilitate repair of the corneal epithelium complained of infection and discharge. Slit-lamp biomicroscopy showed corneal abscessation and hypopyon. Thus, infectious keratitis was diagnosed. Direct microscopy and bacterial culture of a corneal scraping were performed. Because direct microscopy demonstrated the presence of Gram-negative rods, we began treatment with topical 1.5 % levofloxacin and 0.3 % tobramycin every hour. The corneal infiltration increased 4 days after initiating the therapy. The culture report confirmed the presence of a Capnocytophaga species with fluoroquinolone and aminoglycoside resistance and susceptibility to cephalosporins and minocycline. We switched to topical 0.5 % cefmenoxime every hour and oral minocycline at 200 mg day 21. The corneal inflammation subsided within 2 weeks. The bacterial isolate was identified as Capnocytophaga sputigena using 16S rRNA sequencing. Conclusions:We encountered a case of keratitis caused by C. sputigena with reduced fluoroquinolone and aminoglycoside susceptibility.

Capnocytophaga sputigena as a cause of severe orbital cellulitis and subperiosteal abscess in a child

“…The involvement of this bacterium in eye infections is very sporadic, with only a few case reports of keratitis. 2,3 This report is the first to describe a case of pediatric orbital cellulitis with SPA caused by C. sputigena.…”