Capnocytophaga sputigena as a cause of severe orbital cellulitis and subperiosteal abscess in a child

Daigle, Patrick; Lee, Ming-Han; Flores, Mariana; Campisi, Paolo; DeAngelis, Dan

doi:10.1016/j.jcjo.2020.10.012

Cited by 3 publications

(2 citation statements)

References 5 publications

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“…Capnocytophaga species are primarily commensals of the oral cavity in humans and animals, especially dogs and cats. They are recognized as opportunistic pathogens, leading to various extra-oral infections, including severe sepsis [ 2 ], bloodstream infections [ 3 ], abscess [ 4 , 5 ], vertebral osteomyelitis [ 6 ], pneumonia [ 7 ], and perinatal infections [ 8 ] in both immunocompetent and immunosuppressed patients. In addition, Capnocytophaga species have been thought to play a role in cancer development.…”

Section: Introductionmentioning

confidence: 99%

Isolation and Characterization of Capnocytophaga bilenii sp. nov., a Novel Capnocytophaga Species Detected in a Gingivitis Subject

2021

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Capnocytophaga species are commensal gliding bacteria that are found in human and animal oral microbiota and are involved in several inflammatory diseases, both in immunocompromised and immunocompetent subjects. This study contributes to increased knowledge of this genus by characterizing a novel species isolated from a dental plaque sample in a male with gingivitis. We investigated morphological and chemotaxonomic characteristics using different growth conditions, temperature, and pH. Cellular fatty acid methyl ester (FAME) analysis was employed with gas chromatography/mass spectrometry (GC/MS). Phylogenetic analysis based on 16S rRNA, orthologous average nucleotide identity (OrthoANI), and digital DNA–DNA hybridization (dDDH) relatedness were performed. The Marseille-Q4570T strain was found to be a facultative aerobic, Gram-negative, elongated, round-tipped bacterium that grew at 25–56 °C and tolerated a pH of 5.5 to 8.5 and an NaCl content ranging from 5 to 15 g/L. The most abundant fatty acid was the branched structure 13-methyl-tetradecanoic acid (76%), followed by hexadecanoic acid (6%) and 3-hydroxy-15-methyl-hexadecanoic acid (4%). A 16S rDNA-based similarity analysis showed that the Marseille-Q4570T strain was closely related to Capnocytophaga leadbetteri strain AHN8855T (97.24% sequence identity). The OrthoANI and dDDH values between these two strains were, respectively, 76.81% and 25.6%. Therefore, we conclude that the Marseille-Q4570T strain represents a novel species of the genus Capnocytophaga, for which the name Capnocytophaga bilenii sp. nov. is proposed (=CSUR Q4570).

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Section: Introductionmentioning

confidence: 99%

Isolation and Characterization of Capnocytophaga bilenii sp. nov., a Novel Capnocytophaga Species Detected in a Gingivitis Subject

2021

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“…It is not a common pathogen, but it has been reported to cause bacteraemias in patients who are immunosuppressed,9 especially those with haematological malignancy 10 11. It has been reported to cause a variety of other infections such as chorioamnionitis,12 ilio-psoas abscesss,13 empyema,14 community-acquired pnemonia15 and periorbital cellulitis16—and it has recently been reviewed by Liu et al 17. However, to the best of our knowledge, this is the first report of a CNS infection with this organism.…”

Section: Discussionmentioning

confidence: 99%

Treatment ofCapnocytophaga sputigenameningitis in a neurosurgical patient

et al. 2022

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A woman in her 50s developed meningitis following an endoscopic, endonasal resection of a clival meningioma which was complicated by a cerebrospinal fluid (CSF) leak through the nose. CSF analysis showed a raised white cell count, and Capnocytophaga sputigena was isolated. This organism is an oral commensal and is implicated in periodontal disease; the CSF leak explains the portal of entry. C. sputigena is rarely isolated, and this is the first report of a central nervous system (CNS) infection caused by this organism. A worsening of our patient’s dermatological condition, urticaria pigmentosa, coincided with empiric treatment with vancomycin and meropenem, which were therefore discontinued. Treatment was continued with chloramphenicol for 3 weeks, and the patient made a full recovery. Systemic chloramphenicol is uncommonly used in contemporary UK practice, but remains an excellent antibiotic for CNS penetration and it has excellent bioavailability. We anticipate increased chloramphenicol use as the number of multiresistant Gram-negative infection increases.

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Furry, Fomite, and Facultative Anaerobe: A Unique Case of Capnocytophaga canimorsus

Peterson,

Abel,

Reddy

et al. 2023

Cureus

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Capnocytophaga sputigena as a cause of severe orbital cellulitis and subperiosteal abscess in a child

Cited by 3 publications

References 5 publications

Isolation and Characterization of Capnocytophaga bilenii sp. nov., a Novel Capnocytophaga Species Detected in a Gingivitis Subject

Isolation and Characterization of Capnocytophaga bilenii sp. nov., a Novel Capnocytophaga Species Detected in a Gingivitis Subject

Treatment ofCapnocytophaga sputigenameningitis in a neurosurgical patient

Furry, Fomite, and Facultative Anaerobe: A Unique Case of Capnocytophaga canimorsus

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