Capnocytophaga canimorsus meningitis in a 38-year-old immunocompetent woman from household pet exposure

Fennell, Adam G.; Wilson, Kyle S.; Caja, Kevin R; Parikh, Pratik M.

doi:10.1016/j.ajem.2022.03.043

Cited by 2 publications

(4 citation statements)

References 5 publications

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“…Capnocytophaga meningitis has an annual incidence reported as 0.03 per 1 million adults in the United States, which is still considered underdiagnosed due to antibiotic prophylaxis that patients receive for dog bites [6]. In literature reviews, only 33 cases have been described with Capnocytophaga meningitis, making it a rare manifestation [4].…”

Section: Discussionmentioning

confidence: 99%

“…The bacteria will grow in the culture media with 5% sheep blood agar or chocolate agar, incubated in 5-10% carbon dioxide at 37 degree Celsius. Classical lab tests are unreliable, and CSF culture on basic media gives many false-negative results [1,[4][5][6][7]. Molecular tests like CSF polymerase chain reaction (PCR) and 16 small ribonucleic acid (sRNA) gene sequencing are also useful.…”

Section: Discussionmentioning

confidence: 99%

“…Capnocytophaga canimorsus is susceptible to beta-lactams. Higher-generation cephalosporins like ceftriaxone or cefepime are advised for meningitis due to their ability to produce beta-lactamases [1][2][4][5][6]. From literature reviews, mild infections were treated with clindamycin, doxycycline, amoxicillin/clavulanic acid, and fluoroquinolones.…”

Section: Discussionmentioning

confidence: 99%

“…From literature reviews, mild infections were treated with clindamycin, doxycycline, amoxicillin/clavulanic acid, and fluoroquinolones. Carbapenems are used for mixed soft tissue infections or multi-resistant strains [1][2][4][5][6]. Aminoglycosides, anti-staphylococcal penicillins, colistin, and trimethoprim-sulfamethoxazole were found to be ineffective or shown to have resistance.…”

Section: Discussionmentioning

confidence: 99%

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Unique Presentation of a Ubiquitous Organism: Capnocytophaga canimorsus Meningitis With Pneumocephalus

Grewal,

Hager,

Pinelo

et al. 2024

Cureus

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Capnocytophaga canimorsus is a bacterium commonly found in the oral cavities of cats and dogs. Infections are particularly common in immunocompromised patients who have been exposed to bites or come in contact with saliva from these animals. The manifestations of infection include bacteremia, fever, and, rarely, meningitis. Diagnosis is challenging given the bacteria has slow growth on culture media. The organism is susceptible to beta-lactam antibiotics, with higher-generation cephalosporins recommended for treating meningitis. We present a case of a 74-year-old woman with altered mental status and no signs of immunosuppression. She was diagnosed with meningitis caused by Capnocytophaga, with an intriguing finding of pneumocephalus, which is a rare occurrence as per literature review.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

See 2 more Smart Citations

Unique Presentation of a Ubiquitous Organism: Capnocytophaga canimorsus Meningitis With Pneumocephalus

Grewal,

Hager,

Pinelo

et al. 2024

Cureus

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A case report of Capnocytophaga canimorsus meningitis with failure of ceftriaxone therapy

Wildman,

Brockman,

Meatherall

2024

Journal of the Association of Medical Microbiology and Infectio

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Background: Capnocytophaga canimorsus is a gram-negative zoonotic organism that has the potential to cause devastating human infection. Historically, treatment with beta-lactams including penicillin and ceftriaxone has been effective. Methods: We describe a complicated case of C. canimorsus meningitis in a 70-year-old female following a superficial puncture wound from her dog’s teeth. Results: The case described here was complicated by seizures following treatment with ceftriaxone therapy. This case is also the first reported case of C. canimorsus meningitis associated with moyamoya disease and fibromuscular dysplasia. Conclusions: Physicians should be aware of the possibility of ceftriaxone-resistant C. canimorsus and have a low threshold to broaden antimicrobial coverage in the absence of clinical improvement. We also raise the possibility of an association between vasculopathies and unusual infections like C. canimorsus.

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Capnocytophaga canimorsus meningitis in a 38-year-old immunocompetent woman from household pet exposure

Cited by 2 publications

References 5 publications

Unique Presentation of a Ubiquitous Organism: Capnocytophaga canimorsus Meningitis With Pneumocephalus

Unique Presentation of a Ubiquitous Organism: Capnocytophaga canimorsus Meningitis With Pneumocephalus

A case report of Capnocytophaga canimorsus meningitis with failure of ceftriaxone therapy

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