Capnocytophaga canimorsus infections in The Netherlands: a nationwide survey

Dam, Alje P. van; Jansz, A

doi:10.1111/j.1469-0691.2010.03195.x

Cited by 58 publications

(57 citation statements)

References 21 publications

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“…The prevalences of C. canimorsus infections were estimated at 0.5 and 0.63 cases per million inhabitants per year in Denmark (5) and in the Netherlands (15), respectively, but a recent study in the Helsinki area (Finland) estimated the prevalence to be as high as 4.1 cases per million inhabitants per year (16). C.…”

Section: Introductionmentioning

confidence: 99%

Identification of Virulent Capnocytophaga canimorsus Isolates by Capsular Typing

et al. 2017

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Capnocytophaga canimorsus is a dog oral commensal that causes rare but severe infections in humans. C. canimorsus was recently shown to be endowed with a capsular polysaccharide implicated in resistance to the innate immune system of the host. Here, we developed the first C. canimorsus capsular serotyping scheme. We describe nine different serovars (A to I), and this serotyping scheme allowed typing of 25/25 isolates from human infections but only 18/52 isolates from dog mouths, indicating that the repertoire of capsules in the species is vast. However, while only three serovars (A, B, and C) covered 88% of the human isolates tested (22/25), they covered only 7.7% of the dog isolates (4/52). Serovars A, B, and C were found 22.9-, 14.6-, and 4.2-fold more often, respectively, among human isolates than among dog isolates, with no geographical bias, implying that isolates endowed with these three capsular types are more virulent for humans than other isolates. Capsular serotyping would thus allow identification of virulent isolates in dogs, which could contribute to the prevention of these infections. To this end, we developed a PCR typing method based on the amplification of specific capsular genes.

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Section: Introductionmentioning

confidence: 99%

Identification of Virulent Capnocytophaga canimorsus Isolates by Capsular Typing

et al. 2017

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“…Since its discovery in 1976, it is regularly isolated from severe human infections following contact with a dog or a cat123. The incidence of the infection has been estimated to 0.5 and 0.63 case/million inhabitants per year in Denmark and the Netherlands respectively45. However, a recent study carried out in Helsinki concluded that the incidence was of 4.1 cases/million inhabitants per year6 thus showing that the disease is more frequent than previously thought and that it is underestimated probably because of under-diagnosis mainly due to the fastidious growth of these bacteria in culture.…”

mentioning

confidence: 99%

Evidence for a LOS and a capsular polysaccharide in Capnocytophaga canimorsus

Renzi

Ittig

Sadovskaya

et al. 2016

Sci Rep

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Capnocytophaga canimorsus is a dog’s and cat’s oral commensal which can cause fatal human infections upon bites or scratches. Infections mainly start with flu-like symptoms but can rapidly evolve in fatal septicaemia with a mortality as high as 40%. Here we present the discovery of a polysaccharide capsule (CPS) at the surface of C. canimorsus 5 (Cc5), a strain isolated from a fulminant septicaemia. We provide genetic and chemical data showing that this capsule is related to the lipooligosaccharide (LOS) and probably composed of the same polysaccharide units. A CPS was also found in nine out of nine other strains of C. canimorsus. In addition, the genomes of three of these strains, sequenced previously, contain genes similar to those encoding CPS biosynthesis in Cc5. Thus, the presence of a CPS is likely to be a common property of C. canimorsus. The CPS and not the LOS confers protection against the bactericidal effect of human serum and phagocytosis by macrophages. An antiserum raised against the capsule increased the killing of C. canimorsus by human serum thus showing that anti-capsule antibodies have a protective role. These findings provide a new major element in the understanding of the pathogenesis of C. canimorsus.

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“…Campylobacter fetus, Campylobacter coli, Campylobacter hyointestinalis, Campylobacter lari and Campylo bacter upsaliensis are also zoonotic Capnocytophaga canimorsus and Capnocytophaga cynodegmi Dog-bite related; splenectomy and alcoholism may predispose-a recent review in The Netherlands detected more than ten annual cases [16] …”

Section: Bacillus Anthracismentioning

confidence: 98%

The global burden of bacterial and viral zoonotic infections

Christou

2011

Clinical Microbiology and Infection

134

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Bacterial and viral zoonotic infections comprise a practically endless, ever-expanding list of pathogens that have the potential to induce human disease of varying severity, with varying means of transmission to humans (including vector-borne and foodborne agents) and of varying epidemiology. Not all theoretically zoonotic pathogens are truly zoonotic in practice, the prime example being influenza viruses; aviann H5N1 influenza remains strictly zoonotic, whereas novel H1N1 influenza displays an anthropocentric cycle that led to a pandemic, despite being of zoonotic origin. The burden of disease induced by zoonotic and viral pathogens is enormous: there are more than ten bacterial zoonoses, each of which affects hundreds of thousands patients annually, often leading to chronic infections and causing significant economic losses of a medical and livestock-related nature. Viral zoonotic agents are constantly emerging or re-emerging, and are associated with outbreaks of limited or expanded geographical spread: the typical trends of viral zoonotic infections, however, is to extend their ecological horizon, sometimes in an unexpected but successful manner, as in the case of West Nile virus, and in other instances less effectively, as was the case, fortunately, in the case of avian influenza. The majority of bacterial and viral zoonotic infections attract disproportionately low scientific and public health interest. Understanding their burden may allow for improved surveillance and prevention measures.

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Capnocytophaga canimorsus infections in The Netherlands: a nationwide survey

Cited by 58 publications

References 21 publications

Identification of Virulent Capnocytophaga canimorsus Isolates by Capsular Typing

Identification of Virulent Capnocytophaga canimorsus Isolates by Capsular Typing

Evidence for a LOS and a capsular polysaccharide in Capnocytophaga canimorsus

The global burden of bacterial and viral zoonotic infections

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