Capillary electrophoresis of drugs: Current status in the analysis of pharmaceuticals

Nishi, Hiroyuki

doi:10.1002/(sici)1522-2683(19991001)20:15/16<3237::aid-elps3237>3.0.co;2-l

Cited by 65 publications

(11 citation statements)

References 258 publications

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“…The advantages of using CE for pharmaceutical analysis include its speed and low cost of analysis, reductions in solvent consumption and disposal, and the possibility of rapid method development. CE also offers the possibility that a single set of separation conditions can be applied for a wide range of analyses, giving efficiency savings [47,48]. Recently, CE techniques have been applied to the simultaneous determination of coformulated drugs in dosage forms [49,50].…”

Section: Introductionmentioning

confidence: 99%

Simultaneous determination of aliskiren hemifumarate, amlodipine besylate, and hydrochlorothiazide in their triple mixture dosage form by capillary zone electrophoresis

et al. 2014

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A novel, specific, reliable, and accurate capillary zone electrophoretic method was developed and validated for the simultaneous determination of aliskiren hemifumarate, amlodipine besylate, and hydrochlorothiazide in their triple mixture dosage form. Separation was carried out in a fused-silica capillary (57.0 cm total length and 50.0 cm effective length, 75.6 μm internal diameter) by applying a potential of 17 kV and a running buffer consisting of 40 mM phosphate buffer at pH 6.0 with UV detection at 245 nm. The method was suitably validated with respect to specificity, linearity, LOD, and LOQ, accuracy, precision, and robustness. The method showed good linearity in the ranges 1-10, 2.5-25, and 30-300 μg/mL with LODs of 0.11, 0.33, and 5.83 μg/mL for amlodipine besylate, hydrochlorothiazide, and aliskiren hemifumarate, respectively. The proposed method was successfully applied for the analysis of the studied drugs in their coformulated tablets. The results of the proposed method were statistically compared with those obtained by the RP-HPLC reference method revealing no significant differences in the performance of the methods regarding accuracy and precision.

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Section: Introductionmentioning

confidence: 99%

Simultaneous determination of aliskiren hemifumarate, amlodipine besylate, and hydrochlorothiazide in their triple mixture dosage form by capillary zone electrophoresis

et al. 2014

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“…El Deeb, Wätzig, Abd El‐Hady, Sänger‐van de Griend, & Scriba, ; Saz & Marina, ; Štěpánová & Kašička, ). The generally short duration of method development, the simple instrumentation and the use of small sample and electrolyte volumes are, of course, interesting from economic and environmental friendliness point of view (Altria, Kelly, & Clark, ; Nishi, ). The main application areas of CE in drug analysis are in chiral separation (Suliman & Elbashir, ; Suliman, Elbashir, & Schmitz, ), active ingredient assay and impurity determination (Al Azzam, Saad, Makahleah, Aboul‐Enein, & Elbashir, ).…”

Section: Pharmaceutical Analysismentioning

confidence: 99%

Application of capillary electrophoresis with capacitively coupled contactless conductivity detection (CE‐C⁴D): An update

Elbashir

Schmitz

Aboul‐Enein

2017

Biomedical Chromatography

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Capacitively coupled contactless conductivity detection (C D) has appeared as a powerful technique for the detection of compounds lacking chromogenic or fluorogenic group. Since our last review (Biomedical Chromatography 2014; 28: 1502-1506) several new capillary electrophoresis (CE)-C D methods have been reported. This review provides an update of the most recent utilization of CE-C D in the field of pharmaceutical, biomedical and food analysis covering the period from February 2014 to October 2016. The use of CE with C D in the pharmaceutical field has been shown in many papers. Examples illustrate the applicability of CE-C D in the fields of pharmaceutical, biomedical and food analysis. Finally, general conclusions and perspectives are provided.

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“…The generally short duration of method development, the simple instrumentation and the use of small sample and electrolyte volumes are, of course, interesting from financial and environmental perspectives (Altria et al. , 1998; Nishi, 1999). The main application areas of CE in drugs analysis are in chiral separation, main component assay and impurity determination.…”

Section: Application Of Contactless Conductivity Detection In Ce and Mcementioning

confidence: 99%

Applications of capillary electrophoresis with capacitively coupled contactless conductivity detection (CE‐C⁴D) in pharmaceutical and biological analysis

Elbashir

Aboul‐Enein

2010

Biomedical Chromatography

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Conductivity detection, which is universal in capillary electrophoresis (CE), has received considerable attention, since the introduction of the axial capacitively coupled contactless detector C(4)D in 1998. This detector is made of two electrodes which are placed cylindrically around the CE capillary and connected to the AC oscillator. The distance between the electrodes is the detection gap. In this review, applications of CE and MCE with C(4)D in pharmaceutical and biological analysis are presented.

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Capillary electrophoresis of drugs: Current status in the analysis of pharmaceuticals

Cited by 65 publications

References 258 publications

Simultaneous determination of aliskiren hemifumarate, amlodipine besylate, and hydrochlorothiazide in their triple mixture dosage form by capillary zone electrophoresis

Simultaneous determination of aliskiren hemifumarate, amlodipine besylate, and hydrochlorothiazide in their triple mixture dosage form by capillary zone electrophoresis

Application of capillary electrophoresis with capacitively coupled contactless conductivity detection (CE‐C⁴D): An update

Applications of capillary electrophoresis with capacitively coupled contactless conductivity detection (CE‐C⁴D) in pharmaceutical and biological analysis

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Capillary electrophoresis of drugs: Current status in the analysis of pharmaceuticals

Cited by 65 publications

References 258 publications

Simultaneous determination of aliskiren hemifumarate, amlodipine besylate, and hydrochlorothiazide in their triple mixture dosage form by capillary zone electrophoresis

Simultaneous determination of aliskiren hemifumarate, amlodipine besylate, and hydrochlorothiazide in their triple mixture dosage form by capillary zone electrophoresis

Application of capillary electrophoresis with capacitively coupled contactless conductivity detection (CE‐C4D): An update

Applications of capillary electrophoresis with capacitively coupled contactless conductivity detection (CE‐C4D) in pharmaceutical and biological analysis

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Product

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Application of capillary electrophoresis with capacitively coupled contactless conductivity detection (CE‐C⁴D): An update

Applications of capillary electrophoresis with capacitively coupled contactless conductivity detection (CE‐C⁴D) in pharmaceutical and biological analysis