Capillary electromigration techniques for studying interactions between analytes and lipid dispersions

Abstract

CE has matured into a well-known and much used separation technique, with applications covering more or less all types of samples. EKC, which originally was developed for the separation of uncharged compounds, is still today under much development, with main focus on finding the perfect or ideal carriers (pseudo-stationary phase) for a broad range of analytes. In this review, the use of lipid dispersions as pseudostationary phases in EKC performed in capillaries and microchips, in addition to CE frontal analysis and partial filling EKC using lipid dispersions is discussed. Various types of lipid dispersions including liposomes, PEG-stabilized aggregates, proteoliposomes, lipid-based nanoparticles, and commercial lipid emulsions are described. The purpose of the review is to give the reader an overview of how EKC, CE frontal analysis, and partial filling EKC, have been applied to the study of interactions between analytes and lipid membranes.

Effect of ionic liquids on the interaction between liposomes and common wastewater pollutants investigated by capillary electrophoresis

“…The use of liposomes as a pseudostationary phase in capillary electrokinetic chromatography (EKC) is a dynamic method to study interactions between biomimetic cell membranes and analytes [16][17][18]. Liposomes are self-assembled vesicles commonly consisting of phospholipid bilayers enclosing an aqueous solution.…”

Squarticles as the nanoantidotes to sequester the overdosed antidepressant for detoxification

“…5,6 The most likely mechanism of ILE detoxification is the lipid sink effect, the lipophilic drug entrapment into the lipid phase in plasma, which prevents the toxic molecules from ILEs are composed of triglycerides from soybean oil, egg phospholipids, and glycerol. 8 The complications associated with the components of ILEs are relatively common. These include fat overload syndrome, fat embolism, hypertriglyceridemia, and egg allergy.…”

Recent advances in capillary electrophoretic migration techniques for pharmaceutical analysis

“…Log P values of drugs have been estimated by MEKC and MEEKC since many years. Furthermore, liposome electrokinetic chromatography employing liposomes as pseudostationary phase has been used for the characterization of liposomal drug formulations as well as drug lipophilicity and drug–liposome interactions . These electrokinetic techniques have been increasingly employed to predict drug permeability through biological membranes such as skin or the central nervous system (CNS) distribution of drugs.…”