Capillary Alterations in Pigmented Purpuric Disease of the Skin

Davis, Michael J.; Lawler, James C.

doi:10.1001/archderm.1958.01560120043007

Cited by 31 publications

(9 citation statements)

References 2 publications

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“…No abnormalities which could be considered outside the range of normal were found in the nail folds. Examination of the lesions confirmed the presence of purpura and telangiectases but a distinctive pattern for the different diseases was not detect ed [4].…”

Section: Investigationmentioning

confidence: 87%

Pigmented Purpuric Dermatoses

Farrokhzad

Champion²

1970

Dermatology

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Section: Investigationmentioning

confidence: 87%

Pigmented Purpuric Dermatoses

Farrokhzad

Champion²

1970

Dermatology

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“…Capillary microscopy in 12 patients with pigmented purpura disclosed ectatic dilated venules in the subpapillary plexus. 110 Iwatsuki et al 111 found fibrinoid degeneration and occlusive damage with swollen endothelia in three of eight patients with this condition. On direct immunofluorescence examination, each of the eight patients had evidence of C3, C1q, and fibrin within papillary vessels.…”

Section: Other Acquired Primary Cutaneous Diseasesmentioning

confidence: 94%

Pathophysiology of Telangiectasias

2011

Sclerotherapy

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“…raised blood fibrinogen level (Dintenfa.ss, 1962;McKenzie ei al., 1963), a fall in albumin or a rise in globulin, or abnormal plasma proteins as in cryoglobulinaemia. Such changes occur \^'hen a vessel is blocked with aggregates that are unable to disx)erse at a sufficient rate to allow normal blood flow (Bloch, 1956;Knisely et al, 194:7;Davis and Lawler, 1958;Gelin, 1956;Swank et al, 1964). However, aggregation in itself is not necessarily a cause of jiathological ehanges.…”

Section: A 'Partial Obstniclio?i Io Outflow From the Venous Arm Of Thmentioning

confidence: 99%

Microvascular Pattern and Blood Stasis in Skin Disease

Ryan

Copeman

1969

Br J Dermatol

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Some of the factors contributing to severe intravascular stasis in the blood vessels supplying the epidermis are discussed. Changes in blood viscosity result from a variety of factors which act maximally at the peak and in the venous arm of the papillary vessel. The influence of cold on blood viscosity in the papillary vessel is particularly emphasized.The importance of aggregation of blood cells in the superficial vessels and of factors such as platelet aggregation, which may be irreversible and may influence disaggregation are discussed.The presence of *' preferential channels ' * in the capillary meshwork of the skin is illustrated and their significance as passages permitting redistribution of blood away from the epidermis is emphasized.Studies of platelet stickiness in a group of patients suffering from sensitivity to cold and studies on blood flow in one patient with acrocyanosis are presented.CESSATION of blood flow in the superficial microvascular sj'stem for a period sufficiently lorvp; to cause ischaeniic necrosis of the epidermis is rare, but it may occur when there is a summation of several factors tending to increase the viscosity of blood or to encourage intravascnlar clotting. Severe intravascular stasis in the cax^illary loops snx^plying the epidermis may be seen in a number of diseases inclnding severe chilblains, scleroderma, rlieumatoid arthritis, lujius erythematosus, dermatomyositis, acroeyanosis, and many of the dermatological diseases often classified nnder the headino; of " vascnlitis ". There is increasing knowledge al:»out the factors that oneouragc stasis and an interest in mechanisms such as disturbances in tibrinoiytic activity is apparent in dermatological literature (Hatano el al.. 1902; Hatano and Y^aniamoto, 1963; CunlifFe, 1968; Brodthagen et al., 196S and Haustein, 1968).It is the object of this paper to emphasize some of the factors, such as cold, that encourage stasis and to show how the microvascular pattern of the skin can determine the nature ofthe pathology which results from stasis.The patterns of tho microvascular system ofthe skin vary in normal as well as in diseased skin, but tbe commonest pattern of supply to tbe epidermis is ilinstrated in Fig. I. The capillaries that provide nourishment for tbe e])iderniis are loops Avhich arise from a candelabra-like pattern of arterial vessels and tlieir contents di-ain into a venous system which, in ti^e upper dermis, is horizontally disposedthe snbpapillary venous plexus. Tbe greatest density of the vascular system is at the most snperfieial level and thus large quantities of blood are exposed to the temperature of the external environment.

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Capillary Alterations in Pigmented Purpuric Disease of the Skin

Cited by 31 publications

References 2 publications

Pigmented Purpuric Dermatoses

Pigmented Purpuric Dermatoses

Pathophysiology of Telangiectasias

Microvascular Pattern and Blood Stasis in Skin Disease

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