Capillary Activity of Surgical Sutures and Suture- Dependent Bacterial Transport: A Qualitative Study

Geiger, D.; Debus, Eike-Sebastian; Ziegler, Ulrich E.; Larena-Avellaneda, Alex; Frosch, Matthias; Thiede, A.; Dietz, Ulrich

doi:10.1089/sur.2005.6.377

Cited by 35 publications

(21 citation statements)

References 3 publications

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“…Regrettably, the technique had some disadvantages that threw a shadow of doubts on its success rate in the long-term, because the sample of the study was very small and the amount of lingual mucosa involved in the stitches was smaller than the recorded required minimal amount ( Bademkiran et al., 2006 ; Ducharme et al., 2017 ; Kersjes et al., 1984 ; McCormack, 1976 ; Yong et al., 2008 ), and this may, theoretically, allow the animals to continue suckling themselves after surgery, controversial to the observed short-term high success rate in the study. In addition, the technique associated with excessive swelling of the ventral lingual aspect for few days post- surgery, excessive scar formation, and the stitches buried and may be left permanently in the tongue, that might lower the animal's score in markets, and above all of this, neither the idea of using silk material in a wet environment like oral cavity nor the permanent existence of silk materials in the tongue is acceptable by some specialists of oral surgery ( Silver et al., 2016 ) as leaving such braided multifilament suture material, of high capillary ascension, in tissues for long time, increases the potential risk of bacterial transport through it ( Geiger et al., 2005 ), and predisposes the tongue to glossitis or abscess formation.…”

Section: Discussionmentioning

confidence: 99%

Intra-lingual suture pattern for prevention of self-suckling in cows

Seddek

AbdelFattah

Elrashidy

et al. 2019

Veterinary and Animal Science

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Section: Discussionmentioning

confidence: 99%

Intra-lingual suture pattern for prevention of self-suckling in cows

Seddek

AbdelFattah

Elrashidy

et al. 2019

Veterinary and Animal Science

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“…Several in vitro and in vivo studies, 12,14 have suggested that VEGF enhances osteoblast differentiation, migration and activity 10 and osteoclast recruitment. 14 So it is able to enhance capillary density 13 playing an important role in angiogenesis associated with osteogenesis. 11,12,15,16 By that, the presence of VEGF fluorescence pattern in FFB grade 0 supports its osteoinductive properties and the increase in VEGF fluorescence pattern after 6 month of graft could be related to the comparison of osteoblasts, osteoclasts, osteocytes and blood vessels, supporting its role in angiogenesis associated with osteogenesis.…”

Section: Discussionmentioning

confidence: 99%

Histochemical and morphological aspects of fresh frozen bone: a preliminary study

et al. 2016

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Bone graft are used in dentistry for the reconstruction of severely atrophic jaws. Fresh frozen bone has no osteogenic property but it has osteoconductive and osteoinductive properties because its matrix contains growth factors such as vascular endothelial growth factor. The purpose of the present study was to evaluate morphological and protein expression characteristics of fresh frozen bone before graft and after six months of graft in patients who needed maxillary reconstruction. After 6 month of graft we observed the presence of viable bone as evidenced by full osteocyte lacunae and by the presence of RANKR, osteocalcin positive cells and vascular endothelial growth factor. In conclusion, our findings show that the fresh frozen bone after six month of graft is for the most part viable bone, encouraging its use as an alternative to autogenous bone for reconstructing maxillary bone defects prior to implant.

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“…The presence of foreign material increases the risk of infections [6], especially surgical sutures can act as a wick for SSI [7]. So pathogens from the natural skin flora can easily enter wounds via capillary action.…”

Section: Introductionmentioning

confidence: 99%

Novel High Efficient Coatings for Anti-Microbial Surgical Sutures Using Chlorhexidine in Fatty Acid Slow-Release Carrier Systems

et al. 2014

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Sutures can cause challenging surgical site infections, due to capillary effects resulting in bacteria permeating wounds. Anti-microbial sutures may avoid these complications by inhibiting bacterial pathogens. Recently, first triclosan-resistances were reported and therefore alternative substances are becoming clinically relevant. As triclosan alternative chlorhexidine, the “gold standard” in oral antiseptics was used. The aim of the study was to optimize novel slow release chlorhexidine coatings based on fatty acids in surgical sutures, to reach a high anti-microbial efficacy and simultaneously high biocompatibility. Sutures were coated with chlorhexidine laurate and chlorhexidine palmitate solutions leading to 11, 22 or 33 µg/cm drug concentration per length. Drug release profiles were determined in aqueous elutions. Antibacterial efficacy against Staphylococcus aureus was assessed in agar diffusion tests. Biocompatibility was evaluated via established cytotoxicity assay (WST-1). A commercially triclosan-containing suture (Vicryl Plus), was used as anti-microbial reference. All coated sutures fulfilled European Pharmacopoeia required tensile strength and proved continuous slow drug release over 96 hours without complete wash out of the coated drug. High anti-microbial efficacy for up to 5 days was observed. Regarding biocompatibility, sutures using 11 µg/cm drug content displayed acceptable cytotoxic levels according to ISO 10993-5. The highest potential for human application were shown by the 11 µg/cm chlorhexidine coated sutures with palmitic acid. These novel coated sutures might be alternatives to already established anti-microbial sutures such as Vicryl Plus in case of triclosan-resistance. Chlorhexidine is already an established oral antiseptic, safety and efficacy should be proven for clinical applications in anti-microbial sutures.

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Capillary Activity of Surgical Sutures and Suture- Dependent Bacterial Transport: A Qualitative Study

Abstract: All multifilament and pseudomonofilament suture designs allowed transport of colorants and bacteria to some degree. The movement of fluids and bacteria did not depend on the absorptive capacity of the sutures, coating, or the presence of an open suture end.

Cited by 35 publications

References 3 publications

Intra-lingual suture pattern for prevention of self-suckling in cows

Intra-lingual suture pattern for prevention of self-suckling in cows

Histochemical and morphological aspects of fresh frozen bone: a preliminary study

Novel High Efficient Coatings for Anti-Microbial Surgical Sutures Using Chlorhexidine in Fatty Acid Slow-Release Carrier Systems

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