“…During the last 13 mo, the clinical profile of oxaliplatin as an off label therapeutic intervention has been assessed in patients with (1) aggressive relapsed or refractory CLL, as part of a chemotherapeutic regimen involving fludarabine, cytarabine (a nucleoside analog approved for the treatment of various hematological malignancies), and rituximab (a CD20-targeting monoclonal antibody currently employed against CLL and NHL); 72 (2) refractory germ cell tumors, in combination with bevacizumab; 73 (3) breast carcinoma, combined with capecitabine (the precursor of 5-fluorouracil) or docetaxel (a microtubular inhibitor of the taxane family currently employed against various carcinomas); 74 , 75 (4) NSCLC, as part of a docetaxel-based chemotherapy; 76 , 77 (5) advanced nasopharyngeal carcinoma, coupled to radiation therapy; 78 (6) gastric or gastresophageal carcinoma, most frequently in the context of a chemotherapeutic cocktail involving docetaxel, capecitabine, or S-1 (an oral fluoropyrimidine currently approved for the treatment of gastric cancer); 79 - 90 (7) pancreatic, gallbladder, or biliary tract tumors, often in combination with gemcitabine-based chemotherapy; 91 - 94 (8) ovarian or bladder carcinoma, combined with conventional (often gemcitabine-based) therapeutic interventions; 95 - 97 or (9) various solid tumors, again in combination with cytotoxic chemotherapy. 98 , 99 Taken together, the results of these clinical trials, most of which were Phase I or II studies, indicate that oxaliplatin exerts promising antineoplastic effects in patients affected by several tumors other than colorectal carcinoma.…”