Thermosensitive Liposomes for the Delivery of Gemcitabine and Oxaliplatin to Tumors

May, Jonathan P.; Ernsting, Mark J.; Undzys, Elijus; Li, Shyh-Dar

doi:10.1021/mp400321e

Cited by 48 publications

(25 citation statements)

References 42 publications

(84 reference statements)

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“…Except for DOX, there are few drugs used in TSL, according to the published literature (May et al, 2013;Simone et al, 2014). Our team has been studying the TSL for several years.…”

Section: Introductionmentioning

confidence: 99%

Preparation, characterization, and efficacy of thermosensitive liposomes containing paclitaxel

Wang¹,

Zhang²,

Yang³

et al. 2015

Drug Delivery

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To increase the anti-tumor activity of paclitaxel (PTX), novel temperature-sensitive liposomes loading paclitaxel (PTX-TSL) were developed. In vitro, characteristics of PTX-TSL were evaluated. The mean particle diameter was about 100 nm, and the entrapment efficiency was larger than 95%. The phase-transition temperature of PTX-TSL determined by differential scanning calorimetry was about 42C. The result of in vitro drug release from PTX-TSL illustrated that release rate at 37 C was obviously lower than that at 42 C. Stability data indicated that the liposome was physically and chemically stable for at least 3 months at À20 C. In vivo study, after three injections with hyperthermia in the xenograft lung tumor model, PTX-TSL showed distinguished tumor growth suppression, compared with non-temperature-sensitive liposome and free drug. The results of intratumoral drug concentration indicated that PTX-TSL combined with hyperthermia delivered more paxlitaxel into the tumor location than the other two paxlitaxel formulations. In summary, PTX-TSL combined with hyperthermia significantly inhibited tumor growth, due to the increased targeting efficiency of PTX to tumor tissues. Such approach may enhance the delivery efficiency of chemotherapeutics into solid tumors.

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“…Except for DOX, there are few drugs used in TSL, according to the published literature (May et al, 2013;Simone et al, 2014). Our team has been studying the TSL for several years.…”

Section: Introductionmentioning

confidence: 99%

Preparation, characterization, and efficacy of thermosensitive liposomes containing paclitaxel

Wang¹,

Zhang²,

Yang³

et al. 2015

Drug Delivery

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show abstract

“…75 HaT showed a 25-fold improvement in delivery of gemcitabine to the heated tumor relative to free gemcitabine. 75 Unfortunately, superiority of external targeting was not shown in the therapeutic study, because there was no appropriate control group (ie, HaT without hyperthermia).…”

Section: Hyperthermia-activated Cytotoxic Formulationmentioning

confidence: 99%

“…73 Gemcitabine and oxaliplatin have also been encapsulated into the HaT formulation. 75 In a pharmacokinetic study in mice, 40% of the injected dose was detectable 2 hours after intravenous administration of gemcitabine encapsulated in HaT. 75 For oxaliplatin, a three-fold reduction in clearance was observed in comparison with the free drug.…”

Section: Hyperthermia-activated Cytotoxic Formulationmentioning

confidence: 99%

“…75 In a pharmacokinetic study in mice, 40% of the injected dose was detectable 2 hours after intravenous administration of gemcitabine encapsulated in HaT. 75 For oxaliplatin, a three-fold reduction in clearance was observed in comparison with the free drug. 75 HaT showed a 25-fold improvement in delivery of gemcitabine to the heated tumor relative to free gemcitabine.…”

Section: Hyperthermia-activated Cytotoxic Formulationmentioning

confidence: 99%

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Thermosensitive liposomal drug delivery systems: state of the art review

Kneidl¹,

Peller²,

Winter³

et al. 2014

IJN

145

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Thermosensitive liposomes are a promising tool for external targeting of drugs to solid tumors when used in combination with local hyperthermia or high intensity focused ultrasound. In vivo results have demonstrated strong evidence that external targeting is superior over passive targeting achieved by highly stable long-circulating drug formulations like PEGylated liposomal doxorubicin. Up to March 2014, the Web of Science listed 371 original papers in this field, with 45 in 2013 alone. Several formulations have been developed since 1978, with lysolipid-containing, low temperature-sensitive liposomes currently under clinical investigation. This review summarizes the historical development and effects of particular phospholipids and surfactants on the biophysical properties and in vivo efficacy of thermosensitive liposome formulations. Further, treatment strategies for solid tumors are discussed. Here we focus on temperature-triggered intravascular and interstitial drug release. Drug delivery guided by magnetic resonance imaging further adds the possibility of performing online monitoring of a heating focus to calculate locally released drug concentrations and to externally control drug release by steering the heating volume and power. The combination of external targeting with thermosensitive liposomes and magnetic resonance-guided drug delivery will be the unique characteristic of this nanotechnology approach in medicine.

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“…In a pharmacokinetic study in mice, 40% of the injected dose was detectable 2 hours after intravenous administration of gemcitabine encapsulated in HaT [60]. For oxaliplatin, a three-fold reduction in clearance was observed in comparison with the free drug.…”

Section: Hyperthermia-activated Cytotoxic Formulationmentioning

confidence: 99%

Review of current trends in enhancing bioavailability of poorly water soluble drugs by liposomal interventions

Majekodunmi¹

2016

IOSRPHR

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Abstract:One of the several ways of enhancing the solubility of poorly soluble drugs is liposomes formulations. Research on liposomes formulations has progressed from that of conventional vesicles to new generation liposomes, such as cationic liposomes, temperature sensitive liposomes, and virosomes, by modulating the formulation techniques and lipid composition. Thermosensitive liposomes are also a promising tool for external targeting of drugs to solid tumors when used in combination with local hyperthermia or high intensity focused ultrasound. In vivo results have demonstrated strong evidence that external targeting is superior over passive targeting achieved by highly stable long-circulating drug formulations like PEGylated liposomal doxorubicin. This review is to compare the therapeutic effect of current clinically approved liposomebased drugs with free drugs and summarize the historical development and effects of particular phospholipids and surfactants on the biophysical properties and in vivo efficacy of thermosensitive liposome formulations. Drug delivery guided by magnetic resonance imaging is also discussed. The combination of external targeting with thermosensitive liposomes and magnetic resonance-guided drug delivery will be the unique characteristics of this nanotechnology approach in medicine.

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Thermosensitive Liposomes for the Delivery of Gemcitabine and Oxaliplatin to Tumors

Cited by 48 publications

References 42 publications

Preparation, characterization, and efficacy of thermosensitive liposomes containing paclitaxel

Preparation, characterization, and efficacy of thermosensitive liposomes containing paclitaxel

Thermosensitive liposomal drug delivery systems: state of the art review

Review of current trends in enhancing bioavailability of poorly water soluble drugs by liposomal interventions

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