CaO2/Fe3O4 nanocomposites for oxygen-independent generation of radicals and cancer therapy

Photodynamic therapy: Innovative approaches for antibacterial and anticancer treatments

“…Even though it is widely known that hypoxia has a major impact on cancer growth and metastasis, there are currently none of clinically approved anticancer therapeutics for human use that tackle this issue. 523 Many methods listed above regarding oxygen generating, 185,189,206,211,213,[435][436][437][438][439][440][441][442][443][444][446][447][448]450 oxygen self-supply, 451,452 oxygen-independent H 2 O 2 self-supplying 453,454 or oxygen-independent 245 strategies were mentioned. As those methods have been generally assessed as highly efficient, the implementation of any of them in clinical field is considerable as far as the requirements for biocompatibility and safety issues are met.…”

CaO2 nanomedicines: a review of their emerging roles in cancer therapy

“…Furthermore, Mamat et al reported a different approach using oleylamine as a pH-sensitive material to coat a CaO 2 /Fe 3 O 4 nanocomposite for hypoxic cancer CDT. These nanocomposites specifically responded to the acidic tumor microenvironment, releasing active molecules such as H 2 O 2 and Fe 2+ to initiate CDT [33]. Recently, Fe 3+ chelated CaO 2 nanoparticles were prepared as a 'ROS bomb' for CDT, where Fe 3+ was shown to oxidize and deplete GSH, enhancing CDT efficacy [34].…”

Hypoxic tumor therapy based on free radicals

“…The other one is the metal peroxide delivery system, in which H 2 O 2 is released when metal peroxides are induced by specific pH of tumors. 101,109 Chen et al pioneered the preparation of the Fenton-type metal peroxide. They fabricated copper peroxide (CP) nanodots by the binding of H 2 O 2 to Cu 2+ in the presence of poly(vinylpyrrolidone) (PVP) as the stabilizer at room temperature (Fig.…”

“…When the delivery system (e.g., polymeric vehicle and liposome) encapsulating H 2 O 2 accumulates in tumors and is triggered by specific stimuli (such as pH, GSH, and ultrasound (US)), H 2 O 2 will be released from the delivery system. 101,102,109 For example, Li et al encapsulated H 2 O 2 in the polylactic acid-glycolic acid (PLGA) hydrophilic core, and Fe 3 O 4 nanoparticles in the hydrophobic shell. When exposed to US, the polymersome was damaged.…”

“…105 Additionally, Marhaba et al constructed CaO 2 /Fe 3 O 4 nanocomposites coated with oleamine (OA). 101 In an acidic tumor environment, OA dissolved in water, enabling CaO 2 and Fe 3 O 4 to generate H 2 O 2 and Fe 2+ . The Fenton reaction between H 2 O 2 and Fe 2+ then produced enough ˙OH to kill tumor cells.…”