CaO–P2O5–Na2O-based sintering additives for hydroxyapatite (HAp) ceramics

Kalita, Samar J.; Bose, Susmita; Hosick, Howard L.; Bandyopadhyay, Amit

doi:10.1016/j.biomaterials.2003.09.012

Cited by 108 publications

(85 citation statements)

References 26 publications

(48 reference statements)

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“…These values are, indeed, signicantly important when compared with those reported in the literature [30]. Figure 3 illustrates representative microstructure of samples sintered for dierent times which conrmed the relative density variation.…”

Section: Characterizationssupporting

confidence: 62%

Grain Growth in Sintered Natural Hydroxyapatite

et al. 2015

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Hydroxyapatite (HA: Ca10(PO4)6(OH)2) can be synthesized using several methods or manufactured from natural materials such as coral or bone after removal of the organic matter by heating (denoted as NHA). The in vitro and in vivo studies showed that the natural apatite was well tolerated and has better osteoconductive properties than synthetic HA. In addition, the exploitation of natural source represents an economical way of synthesizing NHA by means of sintering, rather than by sol-gel techniques. For these reasons, the NHA was manufactured from cortical bovine bones in all our studies. Moreover, there has been much eort to improve the mechanical properties of HA by introducing foreign oxides or nding out other alternative processes such as grain growth control. Indeed, encouraging lower AGS instead of exaggerated grain growth may be jugged useful for many applications. Since the works carried out on the correlation between AGS and physico-chemical properties of NHA were very limited, the present study was mainly focused on its grain growth. A carful combination between the main parameters controlling NHA production such as milling techniques, compacting pressure, sintering temperature and holding time may lead to an interesting NHA based bio-ceramics. In this way, a simple and energetically vibratory multidirectional milling system using bimodal distribution of highly resistant ceramics has been used for obtaining sub-micron sized NHA powders. For example, the AGS was ranged between 0.75 and 1.40 µm (using intercept method) when NHA samples were sintered at 1250• C for 15 and 480 min, respectively.

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Section: Characterizationssupporting

confidence: 62%

Grain Growth in Sintered Natural Hydroxyapatite

et al. 2015

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“…The degree of densification appeared to depend on the sintering temperature whereas the degree of ionic diffusion was governed by the period of sintering [256]. To enhance sinterability of calcium orthophosphates, a variety of sintering additives might be added [257][258][259][260].…”

Section: Sintering and Firingmentioning

confidence: 99%

Medical Application of Calcium Orthophosphate Bioceramics

Dorozhkin¹

2011

BIO

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In the late 1960's, a strong interest was raised in biomedical applications of ceramic materials (named bioceramics a little bit later). Bioceramics was initially used as reasonable alternatives to metals in order to increase their biocompatibility. However, within a short period, it has grown into a diverse class of biomaterials, presently including three essential types: relatively bioinert, bioactive (or surface reactive) and bioresorbable bioceramics. This review is limited to bioceramics prepared from calcium orthophosphates only, which belong to the categories of bioactive and bioresorbable compounds. There have been a number of important advances in this field during the past 30 -40 years. The research was shifted from an initial study on the develop-ment of bioinert bioceramics towards bioactive and bioresorbable bioceramics, and these different types of calcium orthophosphate bioceramics can be tuned through the structural and compositional control. At the turn of the millennium, a new concept of calcium orthophosphate bioceramics has been developed to promote a regeneration of bones. Current biomedical applications of calcium orthophosphate bioceramics include artificial replacements for hips, knees, teeth, tendons and ligaments, as well as repair for periodontal disease, maxillofacial reconstruction, augmenttation and stabilization of the jawbone, spinal fusion and bone fillers after tumor surgery. Potential future applications of calcium orthophosphate bioceramics are demonstrated in drug delivery systems, effective carriers of growth factors, bioactive peptides and/or various types of cells for tissue engineering purposes.

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“…[2,9] In our previous works, we have demonstrated that the mechanical and degradation properties of TCP can be tailored, without altering its inherent biocompatibility, by the addition of metal oxide dopants, such as NaF, TiO 2 , SiO 2 , CaO, ZnO and Ag 2 O. [10][11][12][13][14] Another interesting alternative to tailor the mechanical and biological properties of calcium phosphate based ceramics is to use biphasic calcium phosphate (BCP).…”

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confidence: 99%

Biphasic Resorbable Calcium Phosphate Ceramic for Bone Implants and Local Alendronate Delivery

Banerjee¹,

Bandyopadhyay²,

Bose³

2010

Adv Eng Mater

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A novel biphasic calcium phosphate ceramic composed of tricalcium phosphate (TCP) and calcium pyrophosphate (CP) is synthesized in order to tailor the biodegradation behavior of the ceramic. The results show that biphasic TCP/CP ceramic has a strength of 62.2 ± 2.1 MPa, which is superior to single‐phase TCP and CP ceramics, which show strengths of 44.3 ± 3.0 and 53.0 ± 4.8 MPa, respectively. In addition, biphasic TCP/CP ceramic displays a controlled strength degradation from 62.2 ± 2.1 to 40.5 ± 1.0 MPa in stimulated body fluid over a period of 28 d. An in vitro cell materials interaction study using human fetal osteoblast cells indicates that TCP/CP ceramic is cytocompatible. TCP/CP ceramic also show a good loading capacity for alendronate. Adsorption of alendronate (AD) on the TCP/CP surface is found to proceed via ligand exchange mechanism and the in vitro release profile of AD from TCP/CP surface is characterized by an initial fast release followed by a slow and sustained release. Strong electrostatic interactions between AD groups and surface Ca2+ ions enable the slow and sustained release of AD. These results demonstrate that the newly developed biphasic ceramic, with its controlled strength degradation and drug release, shows promise for use in orthopedic and tissue engineering applications.

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CaO–P2O5–Na2O-based sintering additives for hydroxyapatite (HAp) ceramics

Cited by 108 publications

References 26 publications

Grain Growth in Sintered Natural Hydroxyapatite

Grain Growth in Sintered Natural Hydroxyapatite

Medical Application of Calcium Orthophosphate Bioceramics

Biphasic Resorbable Calcium Phosphate Ceramic for Bone Implants and Local Alendronate Delivery

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