Cannabis Use and Plasma Human Immunodeficiency Virus (HIV) RNA Levels in Patients Coinfected With HIV and Hepatitis C Virus Receiving Antiretroviral Therapy: Data From the ANRS CO13 HEPAVIH Cohort

Beo, Vincent Di; Salmon‐Céron, Dominique; Salmon, Dominique; Wittkop, Linda; Sogni, Philippe; Esterle, Laure; Trimoulet, Pascale; Izopet, Jacques; Serfaty, Lawrence; Paradis,; Spire, Bruno; Carrieri, Patrizia; Valantin, M.A.; Pialoux, Gilles; Chas, Julie; Poizot‐Martin, Isabelle; Barange, Karl; Naqvi, Alissa; Rosenthal, Éric; Bicart‐See, A.; Bouchaud, Olivier; Gervais, Anne; Lascoux-Combe, Caroline; Goujard, Cécile; Lacombe, Karine; Duvivier, Claudine; Néau, Didier; Morlat, Philippe; Bani‐Sadr, Firouzé; Meyer, Laurence; Boufassa, Faroudy; Autran, Brigitte; Roque, A.M.; Solas, Caroline; Fontaine, Hélène; Costagliola, Dominique; Piroth, Lionel; Simón, Ainhoa; Zucman, David; Boué, François; Miailhes, Patrick; Billaud, Éric; Aumaître, Hugues; Rey, David; Peytavin, Gilles; Petrov-Sanchez,; Lebrasseur-Longuet, Delphine; Usubillaga, Rafael; Terris, Benoı̂t; Trémeaux, Pauline; Katlama, Christine; Stitou, Hind; Cacoub, P.; Nafissa, S.; Benhamou, Yves; Charlotte, Frédéric; Fourati, Slim; Zaegel, O.; Laroche, Hélène; Tamalet, Catherine; Callard, P; Bendjaballah, F.; Amiel, Caroline; Pendeven, Catherine Le; Marchou, B.; Alric, Laurent; Métivier, Sophie; Selves, J.; Larroquette, F.; Rio,; Haudebourg, Juliette; Saint-Paul, M; Monte, A. De; Giordanengo,; Partouche, C.; Martin, Alex; Ziol, Marianne; Baazia, Y.; Iwaka-Bande,; Gerber, Athenaïs; Uzan, Marc; Garipuy, D.; Ferro-Collados, M. J.; Nicot, François; Yazdanpanah, Yazdan; Adle‐Biassette, Homa; Alexandre, Guy P.; Molina, Jean Michel; Bertheau, Philippe; Chaix, Marie Laure; Delaugerre, Constance; Maylin, Sarah; Bottéro, J.; Krause, Jessica; Girard, P; Wendum, Dominique; Cervera, Pascale; Adam, Jamila K.; Viala, C.; Vittecocq, D; Quertainmont, Yann; Teicher, Elina; Pallier, C.; Lortholary, Olivier; Rouzaud, Claire; Lourenco, J; Touam, F.; Louisin, C; Avettand-Fenoel,; Gardiennet, Elise; Mélard, Adeline; Ochoa, Ayleen Cárdenas; Blanchard, E; Castet-Lafarie, S; Cazanave, Charles; Malvy, Denis; Dupon, M.; Dutronc, H.; Dauchy, Frédéric‐Antoine; Lacaze-Buzy, L; Desclaux, Alice; Bioulac‐Sage, Paulette; Reigadas, Sandrine; Lacoste, D.; Bonnet, Fabrice; Bernard, N.; Hessamfar, Mojgan; Paccalin, J; Martell, Chad W.; Pertusa, M.-C.; Vandenhende, Marie-Anne; Mercié, P.; Pistone, Thierry; Receveur, M. C.; Mechain, Murielle; Duffau, Pierre; Rivoisy, Claire; Faure, I.; Caldato, S.; Bellecave, Pantxika; Tumiotto, Camille; Pellegrin, Jean‐Luc; Viallard, Jean‐François; Lazzaro, E.; Greib, C.; Majerholc, C.; Brollo, Marion; Farfour, Éric; Devoto, J. Polo; Kansau, Imad; Chambrin,; Pignon, C.; Berroukeche, L.; Fior, R; Martínez, Vicente; Abgrall, Sophie; Favier, Marion; Deback, Claire; Lévy, Yves; Dominguez, Stéphanie; Lelièvre, Jean Daniel; Lascaux, Anne-Sophie; Melica, Giovanna; Raffi, François; Allavena, Clotilde; Reliquet,; Boutoille, David; Biron, Charlotte; Lefèbvre, M.; Hall, Naomi M.; Bouchez, Sabelline; Rodallec, Audrey; Guen, L. Le; Hemon, C; Peyramond, D.; Chidiac, C.; Ader, Florence; Biron, F.; Boibieux, A.; Cotte, Laurent; Ferry, Tristan; Perpoint, Thomas; Koffi, J.; Zoulim, Fabien; Bailly, François; Lack, Philippe; Maynard, Michaela; Radenne, Sylvie; Amiri, Mehdi; Valour, Florent; Augustin-Normand, C; Scholtès, Caroline; Le-Thi, T.; Chavanet, P.; Huyen, M. Duong Van; Buisson, Marielle; Waldner-Combernoux, A.; Mahy, Sophie; Rousseau, Annick; Martins, Carla Corrêa; Galim, S.; Lambert, D.; N’Guyen, Yohan; Berger, Jean-Luc; Hentzien, Maxime; Brodard,; Partisani, M; Batard, Marie-Laure; Cheneau, Christine; Priester, M; Bernard-Henry, Claudine; Mautort, E de; Fischer, Patricia; Gantner, Pierre; Fafi‐Kremer, Samira; Roustant, F.; Platterier, P; Kmiec, I; Traoré, Lassina; Lepuil, S.; Parlier, S; Sicart-Payssan,; Bedel, E; Anriamiandrisoa, S.; Pomes, Chloe; Mole, M. Leonard; Bolliot, Claudine; Catalán, P; Mebarki, Mouniya; Adda‐Lievin, A.; Thilbaut, P; Ousidhoum, Y; Makhoukhi, F Z; Braik, O.; Bayoud, R; Gatey, Caroline; Pietri, Marie‐Pierre; Baut, Le; Rayana, R. Ben; Bornarel, Dominique; Chesnel, C.; Beniken, D.; Pauchard, Michèle; Akel, Samer; Lions, C.; Ivanova, A; Ritleg, A-S; Debreux, C.; Chalal, Lynda; Zelie, J; Hüe, H.; Soria, A; Cavellec, M; Breau, S.; Joulié, A.; Fisher, P. E.; Gohier, Sandrine; Croisier‐Bertin, D.; Ogoudjobi, S; Brochier, C; Thoirain-Galvan,; Cam, Manuela Le; Chalouni, Mathieu; Conte, Valeria; Dequae-Merchadou, Laurence; Desvallées, Mathilde; Gilbert, Camille; Gillet, S.; Knight, Rod; Lemboub, T; Marcellin, Fabienne; Laurent, Michel; Mora, Muhammad S; Protopopescu, Camélia; Roux, Perrine; Tezkratt, S; Barré, Tangui; Baudoin, Maël; Santos, Melina; Beo, Di; Nishimwe, Marie Libérée

doi:10.1093/cid/ciaa117

Cited by 2 publications

(2 citation statements)

References 9 publications

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“…Regular cannabis use correlates with reduced steatosis, mortality, and insulin resistance in co-infected individuals [ 86 , 87 , 88 ] and is not associated with progression of liver fibrosis [ 89 ]. Importantly, cannabis use showed no observable effect on HIV RNA, viral load, or the circulating CD4 + cell count in HIV/HCV co-infection [ 90 , 91 ], suggesting that the protective effect of cannabinoids in this context is not mediated by altered HIV replication. Supporting the role of cannabinoids as modifiers of HIV/HCV pathology, a variant of cannabinoid receptor 2, 63 RR, is associated with more severe necroinflammation in co-infected individuals [ 92 ].…”

Section: Cannabinoids × Hiv: Prevalence Cross Talk and Clinical Outcomesmentioning

confidence: 99%

Confound, Cause, or Cure: The Effect of Cannabinoids on HIV-Associated Neurological Sequelae

Starr

Jordan‐Sciutto

Mironets

2021

Viruses

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The persistence of human immunodeficiency virus-1 (HIV)-associated neurocognitive disorders (HAND) in the era of effective antiretroviral therapy suggests that modern HIV neuropathogenesis is driven, at least in part, by mechanisms distinct from the viral life cycle. Identifying more subtle mechanisms is complicated by frequent comorbidities in HIV+ populations. One of the common confounds is substance abuse, with cannabis being the most frequently used psychoactive substance among people living with HIV. The psychoactive effects of cannabis use can themselves mimic, and perhaps magnify, the cognitive deficits observed in HAND; however, the neuromodulatory and anti-inflammatory properties of cannabinoids may counter HIV-induced excitotoxicity and neuroinflammation. Here, we review our understanding of the cross talk between HIV and cannabinoids in the central nervous system by exploring both clinical observations and evidence from preclinical in vivo and in vitro models. Additionally, we comment on recent advances in human, multi-cell in vitro systems that allow for more translatable, mechanistic studies of the relationship between cannabinoid pharmacology and this uniquely human virus.

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Section: Cannabinoids × Hiv: Prevalence Cross Talk and Clinical Outcomesmentioning

confidence: 99%

Confound, Cause, or Cure: The Effect of Cannabinoids on HIV-Associated Neurological Sequelae

Starr

Jordan‐Sciutto

Mironets

2021

Viruses

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“…Some individuals receiving therapy for HCV may bene t virologically and symptomatically from modest cannabis use by helping them stick to the di cult medication regimen 23,24 . Faster decay of HIV RNA among cannabis users who were HCV co-infected and reduced risk of steatosis was observed 25,26 . The advantages of using cannabis for treating HCV from a biological and clinical standpoint, as well as the e cacy of this treatment, should be investigated in bigger study populations.…”

Section: Introductionmentioning

confidence: 99%

Geometric Deep learning Prioritization and validation of cannabis phytochemicals as anti-HCV non- nucleoside direct-acting inhibitors

Charles,

Edgar

2024

Preprint

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Introduction: The rate of acute hepatitis C increased by 7% between 2020 and 2021, after the number of cases doubled between 2014 and 2020. With the current adoption of pan-genotypic HCV therapy, there is a need for improved availability and accessibility of this therapy. However, double and triple DAA-resistant variants have been identified in genotypes 1 and 5 with resistance-associated amino acid substitutions (RAASs) in NS3/4A, NS5A, and NS5B 1. The role of this research was to screen for novel potential NS5B inhibitors from the cannabis compound database (CBD) using Deep Learning.Methods Virtual screening of the CBD compounds was performed using a trained Graph Neural Network (GNN) deep learning model. Re-docking and conventional docking were used to validate the results for these ligands since some had rotatable bonds > 10. 31 of the top 67 hits from virtual screening and docking were selected after ADMET screening. To verify their candidacy, six random hits were obtained for FEP/MD and Molecular Simulation Dynamics.Results The top 200 compounds from the deep learning virtual screening were selected, and the virtual screening results were validated by re-docking and conventional docking. The ADMET profiles were optimal for 31 hits. Simulated complexes indicate that these hits are likely inhibitors with suitable binding affinities and FEP energies. Phytil Diphosphate and glucaric acid were suggested as possible ligands against NS5B.

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Cannabis Use and Plasma Human Immunodeficiency Virus (HIV) RNA Levels in Patients Coinfected With HIV and Hepatitis C Virus Receiving Antiretroviral Therapy: Data From the ANRS CO13 HEPAVIH Cohort

Cited by 2 publications

References 9 publications

Confound, Cause, or Cure: The Effect of Cannabinoids on HIV-Associated Neurological Sequelae

Confound, Cause, or Cure: The Effect of Cannabinoids on HIV-Associated Neurological Sequelae

Geometric Deep learning Prioritization and validation of cannabis phytochemicals as anti-HCV non- nucleoside direct-acting inhibitors

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