Geometric Deep learning Prioritization and validation of cannabis phytochemicals as anti-HCV non- nucleoside direct-acting inhibitors
Ssemuyiga Charles,
Mulumba Pius Edgar
Abstract:Introduction: The rate of acute hepatitis C increased by 7% between 2020 and 2021, after the number of cases doubled between 2014 and 2020. With the current adoption of pan-genotypic HCV therapy, there is a need for improved availability and accessibility of this therapy. However, double and triple DAA-resistant variants have been identified in genotypes 1 and 5 with resistance-associated amino acid substitutions (RAASs) in NS3/4A, NS5A, and NS5B 1. The role of this research was to screen for novel potential N… Show more
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