Cannabis use and outcomes after aneurysmal subarachnoid hemorrhage: A nationwide retrospective cohort study

Can Marijuana Use Lead to Cerebral Ischemia?

“…8,17 Subsequent investigations have attempted to assess the association of marijuana with cerebral vasospasm and DCI with mixed results. [17][18][19] This issue's report by Catapano et al 20 is an important addition to this effort, reporting an association between cannabis use, vasospasm, and DCI in patients with aSAH. This conclusion was drawn based on a retrospective propensity score-based comparison from a large single-center experience across 12 years comparing aSAH patients with positive versus negative urine toxicology screens for cannabis.…”

“…8,17 Subsequent investigations have attempted to assess the association of marijuana with cerebral vasospasm and DCI with mixed results. 17–19…”

Cannabis Use Is Not Associated With Aneurysmal Subarachnoid Hemorrhage Complications or Outcomes

“…Given the age dependency of CV and DCI, the skewed age distribution in cannabis users may explain why our study differs from 2 reports that did not include age in multivariable analyses and agrees with larger registry studies that did. [2][3][4][5] Strengths of our study include the largest single-center cohort of cannabis using aSAH patients to date, rigorous accounting of age differences between cohorts, and primary review of all radiographic and clinical data to adjudicate events. Nevertheless, our results have several limitations.…”

“…1 Registry data suggest cannabis use is associated with increased incidence of aneurysmal subarachnoid hemorrhage (aSAH), although not with cerebral vasospasm (CV) or clinical outcomes. 2,3 Conversely, recent singlecenter data suggest increased delayed cerebral ischemia (DCI) after aSAH with cannabis use. 4,5 Using a retrospective cohort study of all aSAH patients presenting to Emory University between January 1, 2012 through December 31, 2019, we present the largest single-center series analyzing the impact of cannabis on aSAH complications and outcomes.…”

“…1 Registry data suggest cannabis use is associated with increased incidence of aneurysmal subarachnoid hemorrhage (aSAH), although not with cerebral vasospasm (CV) or clinical outcomes. 2,3 Conversely, recent single-center data suggest increased delayed cerebral ischemia (DCI) after aSAH with cannabis use. 4,5…”