Cannabis Use Is Not Associated With Aneurysmal Subarachnoid Hemorrhage Complications or Outcomes

Akbik, Feras; Konan, Heather-Destiny; Williams, Kayla P; Ermias, Leelt M; Shi, Yuyang; Takieddin, Obai; Grossberg, Jonathan A; Howard, Brian M.; Tong, Frank; Cawley, C. Michael; Mei, Yajun; Samuels, Owen; Sadan, Ofer

doi:10.1161/strokeaha.122.038951

Cited by 1 publication

(1 citation statement)

References 6 publications

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“…81 However, this was not replicated in another retrospective study examining cannabis use in aneurysmal SAH patients over a 7-year period, wherein authors found only a slight increase in risk of radiographic cerebral vasospasm with cannabis use (61 vs. 51%, p ¼ 0.042), but no increase in risk of DCI or poor outcomes after propensity score matching. 82 In fact, authors found that those who use cannabis were more likely to return home, which may be a consequence of their younger age and a lower Hunt-Hess grade. There is potential interest in the neuroprotective effects of cannabinoids in aneurysmal SAH also.…”

Section: Subarachnoid Hemorrhagementioning

confidence: 99%

Neurological Complications of Cannabinoids

Humayun,

Suarez,

Shah

2024

Semin Neurol

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Cannabinoid use, particularly for recreational purposes, is increasing exponentially across all age groups, especially in younger populations, due to its perceived low risk and legalization. While cannabinoids may be largely considered as safe, there is mounting evidence of increased risk of systemic and neurological complications through their interaction with the poorly understood endocannabinoid receptor network within the central nervous system and other organ systems. Acute cannabinoid exposure can cause neuropsychiatric symptoms in addition to altering cerebral blood flow, leading to cerebrovascular complications such as ischemic stroke, subarachnoid hemorrhage, and reversible cerebral vasoconstriction syndrome (RCVS). Chronic use, particularly among adolescents, may be associated with increased risk of long-term cognitive deficits, schizophrenia, and other neuropsychiatric effects. Synthetic cannabinoids have increased potency, with reports of causing profound neurological complications including coma, seizures, posterior reversible encephalopathy syndrome, and RCVS. Despite increasing evidence, the quality of literature describing neurologic complications with cannabinoids remains limited to case series and retrospective cohort studies, with significant confounding factors such as concomitant use of other illicit drugs, limiting interpretation. In this review, we summarize the effect of cannabinoids on the neurologic system and associated neurological complications.

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Section: Subarachnoid Hemorrhagementioning

confidence: 99%