Cannabis and the exocannabinoid and endocannabinoid systems. Their use and controversies

Millán‐Guerrero, Rebeca O.; Isaís-Millán, Sara

doi:10.24875/gmm.m20000334

Cited by 3 publications

(2 citation statements)

References 22 publications

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“…Cannabidiol (CBD), a non-psychoactive component of Cannabis sativa L., has been purported to have a variety of beneficial physiological effects including but not limited to, pain relief, anti-anxiety, anti-seizure, anti-depressant, anti-oxidant, and anti-inflammatory [1]. Despite the enthusiasm of the CBD industry for these claims, the empirical evidence supporting favorable physiological responses is inconsistent [2,3]. These discrepancies may in part be explained by differences in CBD bioavailability when administered orally [4], that in turn may be influenced by non-standardized CBD formulation, and/or the body size and composition of the recipient.…”

Section: Introductionmentioning

confidence: 99%

Comparison of Five Oral Cannabidiol Preparations in Adult Humans: Pharmacokinetics, Body Composition, and Heart Rate Variability

et al. 2021

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Data supporting the physiological effects of cannabidiol (CBD) ingestion in humans are conflicting. Differences between CBD preparations and bioavailability may contribute to these discrepancies. Further, an influence of body composition on CBD bioavailability is feasible, but currently undocumented. The aims of this study were to: (1) compare the pharmacokinetics of five oral CBD preparations over 4 h; (2) examine the relationship between body composition and CBD pharmacokinetics; and, (3) explore the influence of CBD on heart rate variability. In total, five preparations of CBD, standardized to 30 mg, were orally administered to 15 healthy men and women (21–62 years) in a randomized, crossover design. Prior to and 60 min following CBD ingestion, heart rate variability was determined. Body composition was assessed using dual energy X-ray absorptiometry. Peak circulating CBD concentration, time to peak concentration, and area under the curve was superior in a preparation comprising 5% CBD concentration liquid. Fat free mass was a significant predictor (R2 = 0.365, p = 0.017) of time to peak concentration for this preparation. Several heart rate variability parameters, including peak frequency of the high frequency band, were favorably, but modestly modified following CBD ingestion. These data confirm an influence of CBD preparation and body composition on CBD bioavailability, and suggest that acute CBD ingestion may have a modest influence on autonomic regulation of heart rate.

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Section: Introductionmentioning

confidence: 99%

Comparison of Five Oral Cannabidiol Preparations in Adult Humans: Pharmacokinetics, Body Composition, and Heart Rate Variability

et al. 2021

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“…The World Health Organization considered it to be well-tolerated and with good safety profile. In this sense, its anti-inflammatory effects can be useful and should be investigated in patients with IBD and other inflammatory conditions [56].…”

Section: The Use Of Cannabis Sativa Per Sementioning

confidence: 99%

Cannabis and Canabidinoids on the Inflammatory Bowel Diseases: Going Beyond Misuse

Carvalho

Souza

Marqui

et al. 2020

IJMS

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Inflammatory bowel diseases (IBD) are characterized by a chronic and recurrent gastrointestinal condition, including mainly ulcerative colitis (UC) and Crohn’s disease (CD). Cannabis sativa (CS) is widely used for medicinal, recreational, and religious purposes. The most studied compound of CS is tetrahydrocannabinol (THC) and cannabidiol (CBD). Besides many relevant therapeutic roles such as anti-inflammatory and antioxidant properties, there is still much controversy about the consumption of this plant since the misuse can lead to serious health problems. Because of these reasons, the aim of this review is to investigate the effects of CS on the treatment of UC and CD. The literature search was performed in PubMed/Medline, PMC, EMBASE, and Cochrane databases. The use of CS leads to the improvement of UC and CD scores and quality of life. The medical use of CS is on the rise. Although the literature shows relevant antioxidant and anti-inflammatory effects that could improve UC and CD scores, it is still not possible to establish a treatment criterion since the studies have no standardization regarding the variety and part of the plant that is used, route of administration and doses. Therefore, we suggest caution in the use of CS in the therapeutic approach of IBD until clinical trials with standardization and a relevant number of patients are performed.

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Investigating the Synergistic Effect of Palmitoylethanolamide and Ganaxolone in PTZ-induced Tonic-clonic Seizures

Bagheripoor,

Alimoradian,

Sadegh

2023

SJKU

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Cannabis and the exocannabinoid and endocannabinoid systems. Their use and controversies

Abstract: Recently, the endocannabinoid system was discovered, which consists of receptors, ligands and enzymes that are widely expressed in the brain and the periphery (Table 1), where they act to maintain balance in several homeostatic processes. 7,8

Cited by 3 publications

References 22 publications

Comparison of Five Oral Cannabidiol Preparations in Adult Humans: Pharmacokinetics, Body Composition, and Heart Rate Variability

Comparison of Five Oral Cannabidiol Preparations in Adult Humans: Pharmacokinetics, Body Composition, and Heart Rate Variability

Cannabis and Canabidinoids on the Inflammatory Bowel Diseases: Going Beyond Misuse

Investigating the Synergistic Effect of Palmitoylethanolamide and Ganaxolone in PTZ-induced Tonic-clonic Seizures

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