Cannabis, alcohol and cigarette use during the acute post-concussion period

Lawrence, David Wyndham; Foster, Evan; Comper, Paul; Langer, Laura; Hutchison, Michael; Chandra, Tharshni; Bayley, Mark

doi:10.1080/02699052.2019.1679885

Cited by 18 publications

(19 citation statements)

References 49 publications

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“…A recent study with 307 acute concussion patients with average age 33.7 years did not observe significant impact on recovery by continuous use of cannabis, cigarette, and alcohol within 4 weeks of injury. However, use of cannabis was found to be associated with lower severity than the other two [153]. Most of the time patients are indulged in cannabis use postinjury, unaware of its proven benefits or multiple effects [151,154].…”

Section: Traumatic Brain Injury: Modulation Of Ecs Improves Recovery Post Tbimentioning

confidence: 96%

Targeting the endocannabinoid system: a predictive, preventive, and personalized medicine-directed approach to the management of brain pathologies

et al. 2020

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Cannabis-inspired medical products are garnering increasing attention from the scientific community, general public, and health policy makers. A plethora of scientific literature demonstrates intricate engagement of the endocannabinoid system with human immunology, psychology, developmental processes, neuronal plasticity, signal transduction, and metabolic regulation. Despite the therapeutic potential, the adverse psychoactive effects and historical stigma, cannabinoids have limited widespread clinical application. Therefore, it is plausible to weigh carefully the beneficial effects of cannabinoids against the potential adverse impacts for every individual. This is where the concept of "personalized medicine" as a promising approach for disease prediction and prevention may take into the account. The goal of this review is to provide an outline of the endocannabinoid system, including endocannabinoid metabolizing pathways, and will progress to a more in-depth discussion of the therapeutic interventions by endocannabinoids in various neurological disorders.

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Section: Traumatic Brain Injury: Modulation Of Ecs Improves Recovery Post Tbimentioning

confidence: 96%

Targeting the endocannabinoid system: a predictive, preventive, and personalized medicine-directed approach to the management of brain pathologies

et al. 2020

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“…[23][24][25] Specifically, cannabis, alcohol, and cigarette use have been shown to be prevalent in the acute period after concussion. 26 TBI has been shown to affect many of the neural substrates that mediate substance use behavior and has also been shown to alter neurocircuits, neurotransmitters, and trigger neuroinflammation in executive and reward-related brain regions implicated in the development and maintenance of substance use disorders. 27 Despite much literature indicating increases in substance use after mTBI, we are unable to specifically establish temporality of these factors within the current study.…”

Section: Discussionmentioning

confidence: 99%

“…Participants are asked to indicate the extent to which they are bothered by the questionnaire items over the last 2 weeks. Questions are scored on a 4-point ordinal scale and total score is interpreted as follows; none (1-4), mild (5-9), moderate (10)(11)(12)(13)(14), moderately severe (15)(16)(17)(18)(19), and severe (20)(21)(22)(23)(24)(25)(26)(27).…”

Section: Measures Mental Health Statusmentioning

confidence: 99%

Influence of Mild Traumatic Brain Injury History and Mental Health Status on Alcohol and Cannabis Use in University Athletes

Wilson

Gicas²,

Wójtowicz³

2022

Clinical Journal of Sport Medicine

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Objective: This study examined the relationship between mild traumatic brain injury (mTBI) history, mental health, and sex with single and polysubstance use in university athletes. Design: Observational study. Setting: University in Ontario, Canada. Participants: Participants were identified from a dataset of 416 university athletes ages 18 to 21. Participants were classified based on their substance use habits and, 153 met criteria for the nonsubstance group, 195 for the alcohol use (AU) only group, and 64 polysubstance use group [ie, a combined substance use (AU+) group]. Independent Variables: Athletes received baseline assessments and completed self-reported questions regarding alcohol, cannabis, or other recreational substance use, the Patient Health Questionnaire-9, self-reported mTBI history, and self-reported anxiety, and/or panic disorder endorsement information. Main Outcome Measures: Comparison of mTBI history and mental health status between individuals in the alcohol only or polysubstance use group. Results: Mild traumatic brain injury history was a significant predictor of AU (P , 0.001) and AU+ (P , 0.001). Anxiety endorsement was also a significant predictor of polysubstance use (P , 0.001) and there was a small but nonsignificant association of polysubstance use in men (P 5 0.057). Conclusions: University athletes who experience mTBI are more likely to engage in single or polysubstance use and athletes who experience anxiety are more likely to engage in polysubstance use. Consideration of mTBI history and mental health may inform clinical concussion management for identifying potential high-risk behavior such as polysubstance use in university athletes and tailoring intervention strategies (eg, incorporating education about substance use).

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“…Patients who used medical cannabis also showed a 38% decrease in opioid use or discontinued using opioids altogether. Along those lines, a study performed to determine if cannabis, alcohol, or cigarette use had an impact on recovery from TBI showed that, overall, acute use of these substances did not positively or negatively affect recovery of cognitive or physical activity 25 . However, acute cannabis use was associated with lower symptom severity scores at 3 and 4 weeks after injury while cigarette use was associated with higher symptom severity scores at 1 week.…”

Section: Traumatic Brain Injurymentioning

confidence: 99%

Effects of Marijuana Use in Patients with Orthopaedic Trauma

et al. 2021

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The use of cannabis and cannabis-related products has increased dramatically in the last 2 decades. As states continue to legalize cannabis products, it is important for surgeons to understand the effects they may have on patients who have sustained orthopaedic trauma.Cannabinoids have been shown to decrease the severity of certain symptoms related to traumatic brain injury as well as posttraumatic stress disorder.Cannabinoids can modulate the body’s endocannabinoid system, which can play an important role in bone homeostasis. Activation of cannabinoid receptors has been shown to be bone-protective in adults.Venous thromboembolism is a major concern for trauma patients. Cannabis use has been linked to overall increased rates of venous thromboembolism events.Literature regarding human-based cannabis studies is sparse; however, the growing field is opening new opportunities for research of this topic.

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Cannabis, alcohol and cigarette use during the acute post-concussion period

Cited by 18 publications

References 49 publications

Targeting the endocannabinoid system: a predictive, preventive, and personalized medicine-directed approach to the management of brain pathologies

Targeting the endocannabinoid system: a predictive, preventive, and personalized medicine-directed approach to the management of brain pathologies

Influence of Mild Traumatic Brain Injury History and Mental Health Status on Alcohol and Cannabis Use in University Athletes

Effects of Marijuana Use in Patients with Orthopaedic Trauma

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