Cannabinoids inhibit fertilization in sea urchins by reducing the fertilizing capacity of sperm

The CB2 cannabinoid receptor regulates human sperm cell motility

“…Results obtained from sea urchins showed that cannabinoids can reduce the fertilizing capacity of sperm (19,20) by inhibiting the acrosome reaction (21). It has thus been proposed that cannabinoid receptors in sea urchin sperm could have a role in the blockade of the acrosome reaction (22).…”

Cannabinoids inhibit the respiration of human sperm

“…These cannabinoids are known to reduce sperm count, disrupt spermatogenesis, induce aberrations in sperm morphology, decrease sperm fertilizing capacity, inhibit sperm protein and nucleic acid synthesis, and impair sperm glycolysis (4)(5)(6)(7)(8)(9). Clinically, studies are still needed to confirm whether the use of marijuana adversely affects the fertilizing capacity of human sperm (4).…”

“…Other adverse effects of cannabinoids on the fertilizing capacity of sperm have been reported (7)(8)(9). Both D 8 -THC and D 9 -THC are known to bind to the cannabinoid receptors on the midpiece and head regions of human sperm (10).…”

Endocannabinoids and Kisspeptins: Two Modulators in Fight for the Regulation of GnRH Activity

“…In males, ECS modulates the progression of spermatogenesis, spermatozoa functions and the activity of testicular somatic cells in mammalian, non-mammalian vertebrates as well as in invertebrates. (Battista et al, 2012;Cacciola et al 2008;Cobellis et al, 2006;Cottone et al, 2008;Grimaldi et al, 2009;Maccarrone et al, 2003Maccarrone et al, , 2005Pierantoni et al, 2009, Schuel et al, 1991Wang et al, 2006). In females, ECBs represent fertility signals in folliculogenesis, follicle maturation, oocyte maturation and ovulation (El-Talatini et al, 2009).…”