Cannabinoids inhibit the respiration of human sperm

Badawy, Zaki S.; Chohan, Kazim R.; Whyte, Donna A.; Penefsky, Harvey S.; Brown, Oliver M.; Souid, Abdul Kader

doi:10.1016/j.fertnstert.2008.03.075

Cited by 65 publications

(42 citation statements)

References 20 publications

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“…These observations are supported by both in vitro [111] and in vivo animal studies [102] where it is clearly shown that THC attenuates sperm motility and viability. The fact that THC impairs sperm motility and viability can be explained partially by the fact that it inhibits mitochondrial respiration and activity; therefore, the exposed spermatozoa are starved from energy [112]. These findings are supported by the marked reduction in sperm ATP levels due to THC [111].…”

Section: Effect On Sperm Parameters and Functionmentioning

confidence: 90%

Marijuana, phytocannabinoids, the endocannabinoid system, and male fertility

Plessis

Agarwal

Syriac

2015

J Assist Reprod Genet

117

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Marijuana has the highest consumption rate among all of the illicit drugs used in the USA, and its popularity as both a recreational and medicinal drug is increasing especially among men of reproductive age. Male factor infertility is on the increase, and the exposure to the cannabinoid compounds released by marijuana could be a contributing cause. The endocannabinoid system (ECS) is deeply involved in the complex regulation of male reproduction through the endogenous release of endocannabinoids and binding to cannabinoid receptors. Disturbing the delicate balance of the ECS due to marijuana use can negatively impact reproductive potential. Various in vivo and in vitro studies have reported on the empirical role that marijuana plays in disrupting the hypothalamus-pituitary-gonadal axis, spermatogenesis, and sperm function such as motility, capacitation, and the acrosome reaction. In this review, we highlight the latest evidence regarding the effect of marijuana use on male fertility and also provide a detailed insight into the ECS and its significance in the male reproductive system.

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Section: Effect On Sperm Parameters and Functionmentioning

confidence: 90%

Marijuana, phytocannabinoids, the endocannabinoid system, and male fertility

Plessis

Agarwal

Syriac

2015

J Assist Reprod Genet

117

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“…Moreover, CBs (Δ 8 -THC and Δ 9 -THC) are potent inhibitors of mitochondrial oxygen consumption in human washed spermatozoa, probably through a direct effect on mitochondrial respiratory chain. Conversely, in neat semen, mitochondrial respiration is less affected by CBs treatment, thus suggesting the presence of protective factors in seminal plasma [265]. …”

Section: The Cannabinergic System In the Male Reproductive Tract: mentioning

confidence: 99%

Cannabinoids and Reproduction: A Lasting and Intriguing History

Cacciola¹,

Chianese²,

Chioccarelli³

et al. 2010

Pharmaceuticals

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Starting from an historical overview of lasting Cannabis use over the centuries, we will focus on a description of the cannabinergic system, with a comprehensive analysis of chemical and pharmacological properties of endogenous and synthetic cannabimimetic analogues. The metabolic pathways and the signal transduction mechanisms, activated by cannabinoid receptors stimulation, will also be discussed. In particular, we will point out the action of cannabinoids and endocannabinoids on the different neuronal networks involved in reproductive axis, and locally, on male and female reproductive tracts, by emphasizing the pivotal role played by this system in the control of fertility.

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“…Cannabinoid receptor agonists are reported to inhibit cellular respiration in human sperm and cancer cells [40, 41]. They also reduce UCP-1 and adiponectin expression in brown and white adipocytes, respectively, and increase visfatin expression in white adipocytes, to collectively inhibit thermogenesis and promote a positive energy balance [42].…”

Section: Discussionmentioning

confidence: 99%

Testosterone Rapidly Augments Retrograde Endocannabinoid Signaling in Proopiomelanocortin Neurons to Suppress Glutamatergic Input from Steroidogenic Factor 1 Neurons via Upregulation of Diacylglycerol Lipase-α

Conde

Fabelo²,

Krause³

et al. 2016

Neuroendocrinology

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Testosterone exerts profound effects on reproduction and energy homeostasis. Like other orexigenic hormones, it increases endocannabinoid tone within the hypothalamic feeding circuitry. Therefore, we tested the hypothesis that testosterone upregulates the expression of diacylglycerol lipase (DAGL)α in the hypothalamic arcuate nucleus (ARC) to increase energy intake via enhanced endocannabinoid-mediated retrograde inhibition of anorexigenic proopiomelanocortin (POMC) neurons. Energy intake, meal patterns, and energy expenditure were evaluated in orchidectomized, male guinea pigs treated subcutaneously with testosterone propionate (TP; 400 μg) or its sesame oil vehicle (0.1 mL). TP rapidly increased energy intake, meal size, O₂ consumption, CO₂ production, and metabolic heat production, all of which were antagonized by prior administration of the DAGL inhibitor orlistat (3 μg) into the third ventricle. These orlistat-sensitive, TP-induced increases in energy intake and expenditure were temporally associated with a significant elevation in ARC DAGLα expression. Electrophysiological recordings in hypothalamic slices revealed that TP potentiated depolarization-induced suppression of excitatory glutamatergic input onto identified ARC POMC neurons, which was also abolished by orlistat (3 μM), the CB₁ receptor antagonist AM251 (1 μM), and the AMP-activated protein kinase inhibitor compound C (30 μM) and simulated by transient bath application of the dihydrotestosterone mimetic Cl-4AS-1 (100 nM) and testosterone-conjugated bovine serum albumin (100 nM). Thus, testosterone boosts DAGLα expression to augment retrograde, presynaptic inhibition of glutamate release onto ARC POMC neurons that, in turn, increases energy intake and expenditure. These studies advance our understanding of how androgens work within the hypothalamic feeding circuitry to affect changes in energy balance.

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Cannabinoids inhibit the respiration of human sperm

Cited by 65 publications

References 20 publications

Marijuana, phytocannabinoids, the endocannabinoid system, and male fertility

Marijuana, phytocannabinoids, the endocannabinoid system, and male fertility

Cannabinoids and Reproduction: A Lasting and Intriguing History

Testosterone Rapidly Augments Retrograde Endocannabinoid Signaling in Proopiomelanocortin Neurons to Suppress Glutamatergic Input from Steroidogenic Factor 1 Neurons via Upregulation of Diacylglycerol Lipase-α

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