Cannabinoid use and self-injurious behaviours: A systematic review and meta-analysis

Escelsior, Andrea; Murri, Martino Belvederi; Corsini, G; Serafini, Gianluca; Aguglia, Andrea; Zampogna, Domenico; Cattedra, Simone; Nebbia, Jacopo; Trabucco, Alice; Prestía, Davide; Olcese, Martina; Barletta, Elena; Silva, Beatriz Pereira da; Amore, Mario

doi:10.1016/j.jad.2020.09.020

Cited by 29 publications

(17 citation statements)

References 139 publications

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“…To our surprise, statistical significance between substance abuse experience and the incidence of NSSI in patients with depression and bipolar disorder was not found( P >0.05), which was partially inconsistent with Escelsior’s findings [ 23 ]. This divergence is related to the fact that the substance abuse included in this study is not confined to cannabis, but also extended to various types of substance abuse.…”

Section: Discussioncontrasting

confidence: 90%

“…Besides, there may also be a link between impulsivity and NSSI [ 11 ], which may be more pronounced in individuals with depression or bipolar disorder than in the general population [ 22 ]. A new study revealed that cannabinoid use was connected with an increased prevalence of NSSI by elevating Δ 9 - THC/CBD balance [ 23 ], which makes us to think about the relationship between substance abuse experiences such as alcohol, cannabinoid and NSSI. To date, the existing literature is inconsistent with regard to whether the incidence of NSSI is related to adverse childhood experiences(ACEs).…”

Section: Introductionmentioning

confidence: 99%

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Prevalence and risk factors for non-suicidal self-injury among patients with depression or bipolar disorder in China

Wang

Liu²,

Yang³

et al. 2021

BMC Psychiatry

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Backgrounds Non-suicidal self-injury is a serious health problem among patients with depression or bipolar disorder. However, few studies within the Chinese context have investigated the prevalence of NSSI and its risk factors in above populations. The purpose of this study was to investigate the prevalence of non-suicidal self-injury and its risk factors in patients with depression or bipolar disorder in China. Methods The final sample comprised of 394 inpatients(Mage = 29.71; SDage = 11.95) with depression or bipolar disorder from two psychiatric hospitals in Beijing, China. A General Demographic Data Form, the Non-suicidal Self-injury Questionnaire(NSSI-Q), Impulsivity Item and the Adverse Childhood Experiences-International Questionnaire(ACE-IQ) were completed by all patients. Results Of the 394 patients examined, 245(62.2%) of this sample reported NSSI in past year. Of the 245 patients with NSSI, 135(55.1%) were diagnosed with depression and 110(44.9%) were diagnosed with bipolar disorder. The most common methods of NSSI for female was “pinching”(23.1%) and “scratching”(22.8%), while for male it was “hiting hard objects”(12.7%). By multivariate regression analysis, young age, unemployment, a higher monthly family income, single, impulsivity, long duration of illness and ACEs were risk factors for NSSI in patients with depression and bipolar disorder(P<0.05). Conclusions Our study points to the fact that there was an unfortunate message about the prevalence of NSSI among patients with depression or bipolar disorder in China. It is necessary not only to raise the awareness of NSSI in families and society, but also to formulate targeted assessment and intervention. Moreover, future research should not only focus on individuals being hospitalized, but should be representative of individuals treated at home or in the community because there are no national statistics on NSSI among such patients in China.

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Section: Discussioncontrasting

confidence: 90%

Section: Introductionmentioning

confidence: 99%

Prevalence and risk factors for non-suicidal self-injury among patients with depression or bipolar disorder in China

Wang

Liu²,

Yang³

et al. 2021

BMC Psychiatry

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“…In addition to suicidal behavior‐related outcomes, “self‐harm” and “deliberate self‐harm” defined as intentional self‐injurious behavior regardless of preceding objective have been examined in previous research 3,7,8 . A recent meta‐analysis of nine cohort studies by Escelsior et al reported an association between cannabis use and self‐injurious behavior 9 . Yet, significant knowledge gaps remain in our understanding of the association between specifically adolescent cannabis use and subsequent intentional self‐injury‐related outcomes.…”

Section: Introductionmentioning

confidence: 99%

Does cannabis use in adolescence predict self‐harm or suicide? Results from a Finnish Birth Cohort Study

Denissoff

Niemelä

Scott

et al. 2021

Acta Psychiatr Scand

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Objective Longitudinal studies examining the association between adolescent cannabis use and self‐harm are rare, heterogeneous and mixed in their conclusions. We study this association utilizing a large general population‐based sample with prospective data. Methods The Northern Finland Birth Cohort 1986 (n = 6582) with linkage to nationwide register data was used to study the association of self‐reported cannabis use at age 15–16 years and self‐harm and suicide death until age 33 (until year 2018), based on register information. Cox regression analysis with Hazard Ratios (HR) and 95% confidence intervals (CI) was used. Psychiatric disorders, parental psychiatric disorders and other substance use were considered as confounders. Results In all, 6582 (49.2% male) were included in the analysis, and 377 adolescents (5.7%) reported any cannabis use until the age of 15–16 years. Based on register information, 79 (55.7% male) had visited in health care services due to self‐harm, and 22 (90.1% male) had died by suicide. In crude analyses, adolescent cannabis use was associated with self‐harm (HR = 3.93; 95% CI 2.24–6.90). The association between cannabis use and self‐harm remained statistically significant after adjusting for sex, psychiatric disorders at baseline, frequent alcohol intoxications, other illicit drug use, and parental psychiatric disorders (HR 2.06; 95% CI 1.07–3.95). In contrast, the association of cannabis use with suicide did not reach statistical significance even in crude analysis (HR 2.60; 95% CI 0.77–8.78). Conclusion Cannabis use in adolescence may increase risk of self‐harm independent of adolescent psychopathology and other substance use.

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“…This concept of equifinality also applies to NSSI, which is associated to a greater or lesser degree with many diverse psychiatric disorders and also occurs in non-clinical populations. Although previously identified as a defining characteristic of borderline personality disorder ( Stead et al, 2019 ), NSSI is also linked to other mental health conditions that include, but are not limited to, depressive disorders ( Kaess et al, 2012 ), autism spectrum disorder ( Flowers et al, 2020 ), substance abuse disorders ( Escelsior et al, 2021 ), eating disorders ( Pérez et al, 2018 ), developmental disabilities ( Hoch et al, 2016 ), and posttraumatic stress disorder ( Kimbrel et al, 2016 ). Not all individuals with these disorders also engage in NSSI.…”

Section: Challenges To the Study Of Self-injury In Humans And Monkeysmentioning

confidence: 99%

A Rhesus Monkey Model of Non-suicidal Self-Injury

Novak

Meyer

2021

Front. Behav. Neurosci.

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Non-suicidal self-injury (NSSI) is a type of behavioral pathology seen not only in a variety of clinical conditions but also among non-clinical populations, particularly adolescents and young adults. With the exception of rare genetic conditions that give rise to self-harming behaviors, the etiology of NSSI and the events that trigger specific episodes of this behavior remain poorly understood. This review presents the features of an important, extensively studied animal model of NSSI, namely spontaneously occurring self-injurious behavior (SIB) in rhesus macaque monkeys. We compare and contrast rhesus monkey SIB with NSSI with respect to form, prevalence rates, environmental and biological risk factors, behavioral correlates, proposed functions, and treatment modalities. Many parallels between rhesus monkey SIB and NSSI are demonstrated, which supports the validity of this animal model across several domains. Determining the etiology of spontaneously occurring SIB in monkeys, its underlying biological mechanisms, and which pharmacological agents are most effective for treating the disorder may aid in identifying potential risk factors for the occurrence of NSSI in humans and developing medications for severe cases that are resistant to conventional psychotherapeutic approaches.

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Cannabinoid use and self-injurious behaviours: A systematic review and meta-analysis

Cited by 29 publications

References 139 publications

Prevalence and risk factors for non-suicidal self-injury among patients with depression or bipolar disorder in China

Prevalence and risk factors for non-suicidal self-injury among patients with depression or bipolar disorder in China

Does cannabis use in adolescence predict self‐harm or suicide? Results from a Finnish Birth Cohort Study

A Rhesus Monkey Model of Non-suicidal Self-Injury

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