A Rhesus Monkey Model of Non-suicidal Self-Injury

Novak, Melinda A.; Meyer, Jerrold S.

doi:10.3389/fnbeh.2021.674127

Cited by 9 publications

(11 citation statements)

References 125 publications

(162 reference statements)

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“…Notably, the early onset of NSSI creates greater disease vulnerability. Studies have shown that individuals with NSSI onset younger than 12 years old tend to develop severe NSSI behaviors ( 12 ). Moreover, NSSI in early adolescence may predict the onset of mental disorders in late adolescence.…”

Section: Introductionmentioning

confidence: 99%

Key factors selection on adolescents with non-suicidal self-injury: A support vector machine based approach

Yang

Chen²,

Yao

et al. 2022

Front. Public Health

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Comparing a family structure to a company, one can often think of parents as leaders and adolescents as employees. Stressful family environments and anxiety levels, depression levels, personality disorders, emotional regulation difficulties, and childhood trauma may all contribute to non-suicidal self-injury (NSSI) behaviors. We presented a support vector machine (SVM) based method for discovering the key factors among mazy candidates that affected NSSI in adolescents. Using SVM as the base learner, and the binary dragonfly algorithm was used to find the feature combination that minimized the objective function, which took into account both the prediction error and the number of selected variables. Unlike univariate model analysis, we used a multivariate model to explore the risk factors, which better revealed the interactions between factors. Our research showed that adolescent education level, anxiety and depression level, borderline and avoidant personality traits, as well as emotional abuse and physical neglect in childhood, were associated with mood disorders in adolescents. Furthermore, gender, adolescent education level, physical abuse in childhood, non-acceptance of emotional responses, as well as paranoid, borderline, and histrionic personality traits, were associated with an increased risk of NSSI. These findings can help us make better use of artificial intelligence technology to extract potential factors leading to NSSI in adolescents from massive data, and provide theoretical support for the prevention and intervention of NSSI in adolescents.

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Section: Introductionmentioning

confidence: 99%

Key factors selection on adolescents with non-suicidal self-injury: A support vector machine based approach

Yang

Chen²,

Yao

et al. 2022

Front. Public Health

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“…So even using the popular primate model, the rhesus macaque, it is challenging to imitate NSSI when accompanied by an affective disorder. 33 Therefore, we only selected the potential mechanisms research in humans.…”

Section: Methodsmentioning

confidence: 99%

Potential mechanisms of non-suicidal self-injury (NSSI) in major depressive disorder: a systematic review

Wu,

Zhang,

Chen

et al. 2023

Gen Psych

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BackgroundNon-suicidal self-injury (NSSI) is a frequent and prominent phenomenon in major depressive disorder (MDD). Even though its prevalence and risk factors are relatively well understood, the potential mechanisms of NSSI in MDD remain elusive.AimsTo review present evidence related to the potential mechanisms of NSSI in MDD.MethodsAccording to Preferred Reporting Items for Systematic Reviews and Meta-Analyses 2020 guidelines, articles for this systematic review were searched on Medline (through PubMed), Embase (through Elsevier), PsycINFO (through OVID) and Web of Science databases for English articles, as well as China National Knowledge Infrastructure (CNKI), SinoMed, Wanfang Data, and the Chongqing VIP Chinese Science and Technology Periodical (VIP) Databases for Chinese articles published from the date of inception to 2 August 2022. Two researchers (BW, HZ) independently screened studies based on inclusion and exclusion criteria and assessed their quality.ResultsA total of 25 157 studies were searched. Only 25 of them were ultimately included, containing 3336 subjects (1535 patients with MDD and NSSI, 1403 patients with MDD without NSSI and 398 HCs). Included studies were divided into 6 categories: psychosocial factors (11 studies), neuroimaging (8 studies), stress and hypothalamic-pituitary-adrenal (HPA) axis (2 studies), pain perception (1 study), electroencephalogram (EEG) (2 studies) and epigenetics (1 study).ConclusionsThis systematic review indicates that patients with MDD and NSSI might have specific psychosocial factors, aberrant brain functions and neurochemical metabolisms, HPA axis dysfunctions, abnormal pain perceptions and epigenetic alterations.

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“…Koska itsensä vahingoittamis ta esiintyy ja on esiintynyt useissa varsin erilai sissa yhteiskunnissa (18), on varsin mahdollista, että sitä on tavattu myös ennen kirjoitettua his toriaa eläneissä ihmisyhteisöissä. On myös ha vaittu, että ihmisten lisäksi myös muut eläimet vahingoittavat itseään, erityisesti vankeudessa elävät yksilöt (19)(20)(21)(22)(23).…”

Section: Haitalliset Lapsuudenkokemukset Ja Lapsuusperheen Sosioekono...unclassified

Haitalliset lapsuudenkokemukset ja lapsuusperheen sosioekonominen asema nuorten itsensä vahingoittamista ennustavina tekijöinä

Pitkänen

2023

SLA

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A Rhesus Monkey Model of Non-suicidal Self-Injury

Cited by 9 publications

References 125 publications

Key factors selection on adolescents with non-suicidal self-injury: A support vector machine based approach

Key factors selection on adolescents with non-suicidal self-injury: A support vector machine based approach

Potential mechanisms of non-suicidal self-injury (NSSI) in major depressive disorder: a systematic review

Haitalliset lapsuudenkokemukset ja lapsuusperheen sosioekonominen asema nuorten itsensä vahingoittamista ennustavina tekijöinä

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