Cannabinoid receptor activation inhibits cell cycle progression by modulating 14-3-3β

Jung, Hye-Won; Park, In-Ae; Ghil, Sungho

doi:10.2478/s11658-014-0200-x

Cited by 7 publications

(8 citation statements)

References 48 publications

(31 reference statements)

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“…On the other hand, in excitotoxicity-induced neuronal death, the expression of CB1R and CRIP1a was significantly increased [15], and decreased expression of 14-3-3η was restored during neuroprotection induced by exogenous cannabinoid treatment [24]. Actions of 14-3-3 proteins are closely related to cannabinoid receptor signaling [24,25], but the related mechanism between CRIP1a and 14-3-3 is not clear.…”

Section: Introductionmentioning

confidence: 99%

Tat-Cannabinoid Receptor Interacting Protein Reduces Ischemia-Induced Neuronal Damage and Its Possible Relationship with 14-3-3η

Kwon

Kim

et al. 2020

Cells

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Cannabinoid receptor-interacting protein 1a (CRIP1a) binds to the C-terminal domain of cannabinoid 1 receptor (CB1R) and regulates CB1R activities. In this study, we made Tat-CRIP1a fusion proteins to enhance CRIP1a penetration into neurons and brain and to evaluate the function of CRIP1a in neuroprotection following oxidative stress in HT22 hippocampal cells and transient forebrain ischemia in gerbils. Purified exogenous Tat-CRIP1a was penetrated into HT22 cells in a time and concentration-dependent manner and prevented H2O2-induced reactive oxygen species formation, DNA fragmentation, and cell damage. Tat-CRIP1a fusion protein also ameliorated the reduction of 14-3-3η expression by H2O2 treatment in HT22 cells. Ischemia–reperfusion damage caused motor hyperactivity in the open field test of gerbils; however, the treatment of Tat-CRIP1a significantly reduced hyperactivity 1 day after ischemia. Four days after ischemia, the administration of Tat-CRIP1a restored the loss of pyramidal neurons and decreased reactive astrocytosis and microgliosis induced by ischemic damage in the hippocampal cornu Ammonis (CA)1 region. Ischemic damage decreased 14-3-3η expression in all hippocampal sub-regions 4 days after ischemia; however, the treatment of Tat-CRIP1 ameliorated the reduction of 14-3-3η expression. These results suggest that Tat-CRIP1a attenuates neuronal damage and hyperactivity induced by ischemic damage, and it restores normal expression levels of 14-3-3η protein in the hippocampus.

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Section: Introductionmentioning

confidence: 99%

Tat-Cannabinoid Receptor Interacting Protein Reduces Ischemia-Induced Neuronal Damage and Its Possible Relationship with 14-3-3η

Kwon

Kim

et al. 2020

Cells

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“…Moreover, CBD can not only enhance the expression of PKC but also activates this enzyme by the direct interaction with serotonin receptor (5-HT 1A R) 63 . Moreover, literature data indicate that cannabinoids significantly arrest cells in G2/M-transition 64 , which does not rule out a potential role of the 14-3-3 protein or PKC in this regulation.…”

Section: Discussionmentioning

confidence: 87%

UV induced changes in proteome of rats plasma are reversed by dermally applied cannabidiol

Gęgotek

Atalay

2021

Sci Rep

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UV radiation is known to induce a multiple changes in the metabolism of skin-building cells, what can affect the functioning not only neighboring cells, but also, following signal transduction releasing into the blood vessels, the entire body. Therefore, the aim of this study was to analyze the proteomic disturbances occurred in plasma of chronically UVA/UVB irradiated rats and define the effect on these changes of skin topically applied cannabidiol (CBD). Obtained results showed significant changes in the expression of numerous anti-inflammatory and signaling proteins including: NFκB inhibitor, 14-3-3 protein, protein kinase C, keratin, and protein S100 after UV irradiation and CBD treatment. Moreover, the effects of UVA and UVB were manifested by increased level of lipid peroxidation products—protein adducts formation. CBD partially prevented all of these changes, but in a various degree depending on the UV radiation type. Moreover, topical treatment with CBD resulted in the penetration of CBD into the blood and, as a consequence, in direct modifications to the plasma protein structure by creating CBD adducts with molecules, such as proline-rich protein 30, transcription factor 19, or N-acetylglucosamine-6-sulfatase, what significantly changed the activity of these proteins. In conclusion, it may be suggested that CBD applied topically may be an effective compound against systemic UV-induced oxidative stress, but its effectiveness requires careful analysis of CBD's effects on other tissues of the living organism.

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“…Moreover, some studies reported that CB1 receptors seem to be linked to the activity of the 14-3-3 protein family. In particular, it has been proven that CB1 receptor activation can inhibit cell cycle progression by modulating 14-3-3β ( 13 ).…”

Section: Discussionmentioning

confidence: 99%

Epileptic Phenotype and Cannabidiol Efficacy in a Williams–Beuren Syndrome Patient With Atypical Deletion: A Case Report

et al. 2021

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Epilepsy is a rare clinical manifestation in Williams–Beuren syndrome patients. However, some studies report the presence of infantile spasms and epilepsy in patients carrying larger deletions. Herein, we describe a 13-year-old female affected by Williams–Beuren syndrome and pharmacoresistant epilepsy reporting a de novo large heterozygous 7q11.21q21 deletion (19.4 Mb) also including the YWHAG gene. Studies indicate that cannabidiol is effective as adjunctive therapy for seizures associated with tuberous sclerosis complex, and it is under investigation also in focal cortical dysplasia. When treated with cannabidiol, our patient showed a significant reduction in seizure frequency and intensity, and improved motor and social skills. We hypothesized that CBD could exert a gene/disease-specific effect.

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Cannabinoid receptor activation inhibits cell cycle progression by modulating 14-3-3β

Cited by 7 publications

References 48 publications

Tat-Cannabinoid Receptor Interacting Protein Reduces Ischemia-Induced Neuronal Damage and Its Possible Relationship with 14-3-3η

Tat-Cannabinoid Receptor Interacting Protein Reduces Ischemia-Induced Neuronal Damage and Its Possible Relationship with 14-3-3η

UV induced changes in proteome of rats plasma are reversed by dermally applied cannabidiol

Epileptic Phenotype and Cannabidiol Efficacy in a Williams–Beuren Syndrome Patient With Atypical Deletion: A Case Report

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