Cannabidiol's impact on drug-metabolization

Stöllberger, Claudia; Finsterer, Josef

doi:10.1016/j.ejim.2023.07.029

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Issues Should Be Considered In the Application Of Cbd1

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2024

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“…CBD inhibits the cytochrome P450 enzyme system (CYP450), particularly the CYP3A4 and CYP2C19 enzymes, which play a crucial role in drug metabolism [ 107 ]. Consequently, CBD may alter the plasma concentrations of other drugs metabolized by these enzymes, as previously discussed in Sect.…”

Section: Issues Should Be Considered In the Application Of Cbdmentioning

confidence: 99%

From bench to bedside: the application of cannabidiol in glioma

Feng,

Pan,

et al. 2024

J Transl Med

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Glioma is the most common malignant tumor in central nervous system, with significant health burdens to patients. Due to the intrinsic characteristics of glioma and the lack of breakthroughs in treatment modalities, the prognosis for most patients remains poor. This results in a heavy psychological and financial load worldwide. In recent years, cannabidiol (CBD) has garnered widespread attention and research due to its anti-tumoral, anti-inflammatory, and neuroprotective properties. This review comprehensively summarizes the preclinical and clinical research on the use of CBD in glioma therapy, as well as the current status of nanomedicine formulations of CBD, and discusses the potential and challenges of CBD in glioma therapy in the future.

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Section: Issues Should Be Considered In the Application Of Cbdmentioning

confidence: 99%