Cannabidiol reduces airway inflammation and fibrosis in experimental allergic asthma

Vuolo, Francieli; Abreu, Soraia C.; Michels, Monique; Xisto, Débora G.; Blánco, N.; Hallak, Jaime E. C.; Zuardi, Antônio Waldo; Crippa, José Alexandre S; Reis, Cardine Martins dos; Bahl, Marina Mônica; Pizzichinni, Emílio; Silva, Rosemeri Maurici da; Pizzichinni, Márcia; Rocco, Patrícia Rieken Macêdo; Dal‐Pizzol, Felipe

doi:10.1016/j.ejphar.2018.11.029

Cited by 99 publications

(73 citation statements)

References 42 publications

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“…59 Use of ovalbumin to induce an asthma-like disease in mice demonstrated that some cytokines and chemokines induced in the lungs of mice that were suppressed by CBD (IL-4, IL-5, IL-13, and eotaxin) were differentially regulated by CB receptors. 60 Specifically, CBD-induced suppression of IL-5 was reversed in the presence of the CB 2 receptor antagonist in bronchoalveolar lavage fluid and lung tissue, but there was no clear receptor dependence identified for CBD's suppression of IL-4, IL-13, or eotaxin. 60 Thus, several studies do suggest a possible role for cannabinoid receptors in CBD-mediated suppression of inflammatory effects.…”

Section: Identification Of Cbd Receptors and Other Targetsmentioning

confidence: 93%

Immune Responses Regulated by Cannabidiol

Nichols

Kaplan

2020

Cannabis and Cannabinoid Research

198

176

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Introduction: Cannabidiol (CBD) as Epidiolex Ò (GW Pharmaceuticals) was recently approved by the U.S. Food and Drug Administration (FDA) to treat rare forms of epilepsy in patients 2 years of age and older. Together with the increased societal acceptance of recreational cannabis and CBD oil for putative medical use in many states, the exposure to CBD is increasing, even though all of its biological effects are not understood. Once such example is the ability of CBD to be anti-inflammatory and immune suppressive, so the purpose of this review is to summarize effects and mechanisms of CBD in the immune system. It includes a consideration of reports identifying receptors through which CBD acts, since the ' 'CBD receptor,' ' if a single one exists, has not been definitively identified for the myriad immune system effects. The review then provides a summary of in vivo and in vitro effects in the immune system, in autoimmune models, with a focus on experimental autoimmune encephalomyelitis, and ends with identification of knowledge gaps. Conclusion: Overall, the data overwhelmingly support the notion that CBD is immune suppressive and that the mechanisms involve direct suppression of activation of various immune cell types, induction of apoptosis, and promotion of regulatory cells, which, in turn, control other immune cell targets.

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Section: Identification Of Cbd Receptors and Other Targetsmentioning

confidence: 93%

Immune Responses Regulated by Cannabidiol

Nichols

Kaplan

2020

Cannabis and Cannabinoid Research

198

176

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“…It is currently advertised to benefit many different maladies including sinusitis and allergy. Although there have been a couple of studies evaluating its role in airway inflammation, there are currently no studies on its efficacy in sinusitis or rhinitis . Consumption of CBD oil is also not without risks, as it can cause dry mouth, drowsiness, fatigue, diarrhea, and interact with anticoagulant medications.…”

Section: Discussionmentioning

confidence: 99%

Alternative therapies for sinusitis and rhinitis: a systematic review utilizing a modified Delphi method

Gettelfinger

Ting

et al. 2020

Int Forum Allergy Rhinol

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Background Sinusitis and rhinitis are common diseases for which patients seek medical attention. Alternative therapies constitute a multibillion‐dollar industry despite poorly established efficacy and safety profiles. This study was designed to identify and grade the evidence for alternative therapies purported to treat sinusitis and rhinitis. Methods A modified Delphi method was used to establish a consensus opinion among rhinology experts of the current evidence for efficacy, potential harm, and future research needs for alternative therapies in sinusitis and rhinitis. Following the initial Delphi round of discussion, a Google search query was performed to identify topics and review online reports of benefit. Subsequent rounds established search criteria and inclusion/exclusion criteria for a systematic literature review utilizing PubMed, EMBASE, and Cochrane databases. Centre for Evidence‐Based Medicine (CEBM) and Grading of Recommendations, Assessment, Development and Evaluations (GRADE) criteria were used to assess levels of evidence and recommendations. Final Delphi rounds were performed until consensus opinions could be reached. Results Over 60 potential alternative therapies for sinusitis and rhinitis were identified. The literature review included 2066 titles with 220 full‐text articles found to be relevant. Most of the therapies had little to no scientific evidence; however, acupuncture, capsaicin, bromelain, and butterbur extract currently have low to moderate‐high GRADE rating. Allergic rhinitis was the most common disease studied. Conclusion Some alternative therapies show promise as potential treatments for sinusitis and rhinitis, mostly compared to placebo. Comparisons to traditional therapies are lacking. For other alternative therapies, many websites included unsubstantiated claims of benefit and ignored potential side effects for which patients should be warned appropriately.

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“…Asthma has become a serious public health problem in the world, and results in a global prevalence ranging from 1% to 18% [1][2][3]. Its manifestations are derived from an underlying chronic inflammatory process mediated and orchestrated by products of certain immune cells [4][5][6][7][8]. However, no effective preventive measures or cure for asthma have been found, and current treatment aims to achieve and maintain clinical control.…”

Section: Introductionmentioning

confidence: 99%

The efficacy of Nigella sativa supplementation for asthma control: a meta-analysis of randomized controlled studies

Han

Shi

2021

pdia

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A b s t r a c tIntroduction: The efficacy of Nigella sativa supplementation for asthma control remains controversial. We have conducted a systematic review and meta-analysis to explore the influence of Nigella sativa supplementation on asthma control. Material and methods: We have searched PubMed, EMBASE, Web of science, EBSCO, and Cochrane library databases through June 2019 for randomized controlled trials (RCTs) assessing the efficacy of Nigella sativa supplementation for asthma control. Results: Four RCTs are included in the meta-analysis. Overall, compared with the control group for asthma, Nigella sativa supplementation is associated with the increased ACT scores (SMD = 0.50; 95% CI: 0.11-0.88; p = 0.01), and FEV1 (SMD = 1.84; 95% CI: 0.07-3.60; p = 0.04), but demonstrates no obvious impact on PEF (SMD = 3.11; 95% CI: -1.30 to 7.52; p = 0.17), IL-4 (SMD = -0.31; 95% CI: -1.21 to 0.59; p = 0.50), or IFN-γ (SMD = 1.11; 95% CI: -0.44 to 2.67; p = 0.16).Conclusions: Nigella sativa supplementation may provide additional benefits for the treatment of asthma.

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Cannabidiol reduces airway inflammation and fibrosis in experimental allergic asthma

Cited by 99 publications

References 42 publications

Immune Responses Regulated by Cannabidiol

Immune Responses Regulated by Cannabidiol

Alternative therapies for sinusitis and rhinitis: a systematic review utilizing a modified Delphi method

The efficacy of Nigella sativa supplementation for asthma control: a meta-analysis of randomized controlled studies

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