Canine Vogt‐Koyanagi‐Harada‐like Syndrome in Two Siberian Husky Dogs

Abstract

A syndrome of uveitis, associated with depigmentation and erosion of areas of skin and mucous membrane on the head and, in one dog, on the scrotum, was observed by the authors in two male Siberian Huskies. These clinical signs are similar to the Vogt-Koyanagi-Harada syndrome in man. Histological examination of the affected skin revealed a lichenoid dermatitis of the upper dermis. Intensive topical therapy with mydriatic and cycloplegic drugs and corticosteroids coupled with systemic prednisolone and azathioprine were used to control the disease. Both subjects were monitored for 10 months and retained useful vision. The skin and oral lesions resolved.

Uveodermatologic syndrome in a Brazilian Fila dog

“…(1977) 2 . Since then, several other affected breeds including the Siberian Husky, Dachshund, Fox Terrier, Shetland Sheepdog, Saint Bernard, Irish Setter, Old English Sheepdog, and Chow‐Chow have been reported 3–10 …”

An immunohistochemical study of uveodermatologic syndrome in two Japanese Akita dogs

“…Uveodermatologic syndrome (UVD) is a chronic panuveitis with cutaneous involvement resulting in vitiligo and poliosis, which was first described in two Japanese Akitas in 1977 1 . Since then, other case reports have been published documenting a similar syndrome in other breeds such as the Siberian Husky and Golden Retriever, although the majority of cases have been in the Japanese Akita 1–13 …”

“…Both globes and skin biopsies from normal appearing facial skin and nasal planum were submitted for histopathologic examination. Nasal planum was selected for biopsy due to dense pigmentation and a previously published predilection for cutaneous clinical signs 2,5,8 …”

“…Necropsy samples of depigmented skin from the face and nasal planum, and one globe were taken. The cutaneous sites were selected on the basis of clinical evidence of depigmentation and on a predilection for this disease already documented 2,5,8 …”

Uveodermatological Syndrome in a Cocker-Poodle Mixed-Breed Dog

“…The Akita has been notably the most affected dog breed (ASAKURA et al, 1977;HASEGAWA, 1985;ROMATOWSKI, 1985;BEDFORD, 1986;COTTRELL;BARNETT, 1987;FURLONG et al, 1989;LINDLEY et al, 1990;BARROS et al, 1991;MURPHY et al, 1991). There have been reports of the occurrence of this disease in other breeds as Samoyed, Irish Setter (BUSSANICH et al, 1982), Golden Retriever, Old English Sheepdog, Saint Bernard, Shetland Sheepdog (KERN et al, 1985), Australian Shepherd (FABRIÈS, 1984;KERN et al, 1985), Siberian Husky (FABRIÈS, 1984;KERN et al, 1985;TACHIKAWA et al, 1990;VERCELLI;TARAGLIO, 1990;GUAGUERE-LUCAS et al, 1995;DENEROLLE et al, 2000), Chow Chow (MORGAN, 1989;WARMOES, 1999), Dachshund (HERRERA and DUCHENE, 1998) and Fox Terrier (SLINCKX;FONTAINE, 1999).…”