Uveodermatological Syndrome in a Cocker-Poodle Mixed-Breed Dog

Godoy, C.A.L.; Safatle, Angélica Mendonça Vaz; Teixeira, A.L.; Souza, M. S.; Barros, P S M

doi:10.5380/avs.v8i1.4013

Cited by 2 publications

(1 citation statement)

References 7 publications

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“…The classical canine cases of the syndrome has been histologically characterized by non-necrotic granulomatous uveitis causing bilateral thickening of the uvea, scattered melanin pigment, bilateral involvement and relative absence of inflammatory changes in retina (2)(3)(4)(5)(6)(7)(9)(10)(11)(12). The diagnosis of chronic form of VKH was based on lymphoplasmacytic uveitis, evidence of melanin containing macrophages, pigment clumping, pigment incontinence, depigmentation of epithelial cells and bilateral involvement of the eyes.…”

Section: Introductionmentioning

confidence: 99%

Novel of chronic phase of Canine Uveodermatologic Syndrome (Vogt- Koyanagi-Harada-like syndrome)

DUBIELZIG¹

2014

Ankara Üniversitesi Veteriner Fakültesi Dergisi

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Summary:The aim of the present study is to evaluate morphological findings of chronic uveodermatologic syndrome (UDS) in dogs. Five canine cases which had been diagnosed as chronic form of canine UDS pathologically were re-evaluated for histopathologically and immunohistochemically (CD3 and CD20). The dogs were from different breeds with the mean of 6-year-old (range 3 to 12 years) and enucleated globes were submitted from the different animal hospitals with the history of bilateral uveitis that was uncontrollable with anti-inflammatories, followed by glaucoma and blindness. Microscopically; mild to moderate lymphoplasmacytic uveitis together with histiocytic pigment phagocytosis, melanin containing macrophage infiltration and epithelial depigmentation were the main findings detected. Secondary glaucoma, synechia and iris bombé were also seen. The B lymphocytes were predominantly found in affected parts of the globe including iris, ciliary body, cilliary process and choroid. In conclusion, the chronic phase of canine uveodermatologic syndrome is characterized by mild to moderate lymphoplasmacytic uveitis or panuveitis. Although chronic form has not been reported in earlier canine reports, it is compatible with the chronic form of Vogt-KoyanagiHarada cases in humans.

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Section: Introductionmentioning

confidence: 99%

Novel of chronic phase of Canine Uveodermatologic Syndrome (Vogt- Koyanagi-Harada-like syndrome)

DUBIELZIG¹

2014

Ankara Üniversitesi Veteriner Fakültesi Dergisi

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Clinical findings and outcomes for dogs with uveodermatologic syndrome

Zarfoss¹,

Tusler²,

Kass³

et al. 2018

javma

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OBJECTIVE To evaluate signalment, clinical signs, treatment, and factors affecting visual prognosis in dogs with uveodermatologic syndrome (UDS). DESIGN Retrospective case series and nested cohort study. ANIMALS 50 dogs (37 Akitas and 13 non-Akitas) with UDS evaluated at 4 ophthalmology practices. PROCEDURES Data were collected from the medical records regarding signalment, clinical signs, biopsy results, medications, adverse effects, vision and glaucoma status at initial and subsequent examinations, and duration of follow-up. Various factors were examined for associations with development of blindness or glaucoma following initial examination. RESULTS The most common ophthalmic signs included aqueous flare (n = 35 [70%]), iris abnormalities (29 [58%]), retinal detachment (23 [46%]), and choroidal depigmentation or chorioretinal infiltrates (10 [20%]). At initial examination, 36% (18/50) of dogs had glaucoma and 57% (26/46) were blind in both eyes. Twenty-five (50%) dogs had vision at their final visit, representing 78% of the 32 dogs that had vision at initial examination or regained vision during the follow-up period. In dogs that lost vision, median time to permanent blindness in both eyes was 13.5 months (range, 0.4 to 59 months) after initial examination. No significant associations with time to glaucoma or vision loss were identified for signalment variables, specific medications, or duration of clinical signs prior to initial examination. CONCLUSIONS AND CLINICAL RELEVANCE UDS commonly resulted in glaucoma, vision loss, or both in affected dogs. No evaluated factor was associated with visual prognosis; however, a subset of patients maintained vision through to the final recheck examination.

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Uveodermatological Syndrome in a Cocker-Poodle Mixed-Breed Dog

Cited by 2 publications

References 7 publications

Novel of chronic phase of Canine Uveodermatologic Syndrome (Vogt- Koyanagi-Harada-like syndrome)

Novel of chronic phase of Canine Uveodermatologic Syndrome (Vogt- Koyanagi-Harada-like syndrome)

Clinical findings and outcomes for dogs with uveodermatologic syndrome

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