2003
DOI: 10.1136/jmg.40.5.320
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Canine tricuspid valve malformation, a model of human Ebstein anomaly, maps to dog chromosome 9

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Cited by 71 publications
(55 citation statements)
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“…5 were found in patients with Ebstein anomaly. 6,20 Andelfinger et al 21 demonstrated linkage between tricuspid valve formation and canine chromosome 9 in a region systemic to human chromosome 1q12-q23. Of interest, penetrance of Ebstein anomaly in the dog was estimated to be 68%.…”
Section: Discussionmentioning
confidence: 99%
“…5 were found in patients with Ebstein anomaly. 6,20 Andelfinger et al 21 demonstrated linkage between tricuspid valve formation and canine chromosome 9 in a region systemic to human chromosome 1q12-q23. Of interest, penetrance of Ebstein anomaly in the dog was estimated to be 68%.…”
Section: Discussionmentioning
confidence: 99%
“…By way of example, genetic linkage analysis has been used to study familial tricuspid dysplasia in the Labrador Retriever 60 . Investigators identified three purebred Labrador Retriever kindreds that were enriched for tricuspid valve dysplasia and carried out a 15cM genome scan.…”
Section: Mapping Disease Causing Locimentioning
confidence: 99%
“…Tricuspid valve dysplasia (TVD) in dogs encompasses a spectrum of congenital malformations of the tricuspid valve (TV) apparatus including focal or diffuse thickening of the leaflets, underdevelopment or undifferentiated chordae tendineae (CT) and papillary muscles (PM), incomplete separation of valve components from the ventricular wall and focal agenesis of valvular tissue, resulting in valvular insufficiency or rarely stenosis (Famula et al, 2002;Andelfinger et al, 2003;MacDonald, 2006;Ohad et al, 2013;Adin, 2014;Lake-Bakaar et al, 2017) (Fig. 1).…”
Section: Introductionmentioning
confidence: 99%
“…In "tricuspid valve dysplasia", the leaflets and tension apparatus are malformed but are not displaced (Becker et al, 1971;Lang et al, 1991). This terminology has been applied to veterinary cardiology (Eyster et al, 1977;Cave, 2001;Andelfinger et al, 2003;Takemura et al, 2003;Sousa et al, 2006;Choi et al, 2009).In dogs, TVD is a rare congenital disease, affecting most commonly Labrador retriever (Wright et al, 2001).…”
Section: Introductionmentioning
confidence: 99%
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