Canine transmissible venereal tumor genome reveals ancient introgression from coyotes to pre-contact dogs in North America

Wang, Xuan; Zhou, Bowen; Yang, Melinda A.; Yin, Tingting; Chen, Fang-Liang; Ommeh, Sheila; Esmailizadeh, Ali; Turner, Melissa M.; Poyarkov, Andrei D.; Savolainen, Peter; Wang, Guodong; Fu, Qiaomei; Zhang, Yaping

doi:10.1038/s41422-019-0183-2

Cited by 9 publications

(7 citation statements)

References 15 publications

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“…We included 103 canids from previous studies (Auton et al., 2013, Botigué et al., 2017, Decker et al., 2015, Freedman et al., 2014, Marsden et al., 2016, Skoglund et al., 2015, Tang et al., 2019, vonHoldt et al., 2016, Wang et al., 2019a, Wang et al., 2016a, Wang et al., 2013, Wang et al., 2019b, Zhang et al., 2014), including an ancient gray wolf, Taimyr; 25 modern gray wolves chosen from regions overlapping their current ranges; 70 domestic dogs from all over the world; two jackals; two coyotes; one red wolf; one dhole; and one Andean fox (Figure 1, Table S2). We obtained 13.74 million SNPs, including 4.25 million transversions for further analysis (Transparent Methods).…”

Section: Resultsmentioning

confidence: 99%

Genomic Approaches Reveal an Endemic Subpopulation of Gray Wolves in Southern China

et al. 2019

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Although gray wolves (Canis lupus) are one of the most widely distributed terrestrial mammals, their origins in China are not well understood. We sequenced six specimens from wolf skins, showing that gray wolves from Southern China (SC) derive from a single lineage, distinct from gray wolves from the Tibetan Plateau and Northern China, suggesting that SC gray wolves may form a distinct subpopulation. Of SC gray wolves, one wolf from Zhejiang carries a genetic component from a canid and had gene flow from a population related to or further diverged from wolves than the dhole. This may indicate that interspecific gene flow likely played an important role in shaping the speciation patterns and population structure in the genus Canis. Our study is the first to survey museum gray wolves' genomes from Southern China, highlighting how sequencing the paleogenome from museum specimens can help us to study extinct species.

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Section: Resultsmentioning

confidence: 99%

Genomic Approaches Reveal an Endemic Subpopulation of Gray Wolves in Southern China

et al. 2019

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“…Nonetheless, CTVT genome has been described as having a hybrid of canine ( Canis latrans ) introgression yet with stable genomic constitution. 13 , 14 In other words, it has accumulated more mutations than any known human tumor resulting in large-scale structural variation (SV) which has affected more than 2,000 genes, 13 , 15 , 16 including those related to clonal rearrangements in the MYC (MYC Proto-Oncogene, BHLH Transcription Factor), 17 homozygous deletion of suppressor gene CDKN2A (Cyclin Dependent Kinase Inhibitor 2A), and homozygous loss of DNA repair gene SETD2 (SET Domain Containing 2). 13 Therefore, tracking germline variants in CTVT has been very challenging over the years; however, they provide useful insights regarding evolutionary origin and effects of germline variants on tumors.…”

Section: Introductionmentioning

confidence: 99%

Germline gene fusions across species reveal the chromosomal instability regions and cancer susceptibility

Zhou,

Wu,

Mauki

et al. 2023

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“…Canine transmissible venereal tumour (TVT) is an infectious tumour of dogs 1–4 . TVT is transmitted between dogs by direct transplantation of living tumour cells from one dog to another, typically during mating when abraded mucosa is exposed to the tumour of an infected dog 4 .…”

Section: Introductionmentioning

confidence: 99%

Temporospatial distribution and country of origin of canine transmissible venereal tumours in the UK

et al. 2021

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Background Transmissable venereal tumour (TVT) is a tumour transplanted by physical contact between dogs. Lesions typically affect the genitalia. TVT is not considered enzootic in the United Kingdom (UK), with cases seen in imported dogs. We sought to determine the patient characteristics, temporal and spatial distribution and country of origin of affected dogs in the UK. Methods Electronic pathology records (EPRs) from four UK veterinary diagnostic laboratories collected between 2010 and 2019 were searched for the terms ‘venereal’ or ‘TVT’. Reports were reviewed for statements confirming a TVT and descriptive statistics collated. Results Of 182 EPRs matching the search terms, a diagnosis of TVT was confirmed in 71. Country of origin was noted in 36 cases (50.7%) with Romania being the most common (n = 29). Cases were reported in each UK constituent country, with the majority being in England (64, 90.1%). The incidence of TVT diagnosis increased over the last decade (z = 2.78, p = 0.005). Conclusion The incidence of TVT diagnosed in the UK is increasing. The majority of cases were known to have been imported. Autochthonous transmission cannot be excluded due to study design. Vets are encouraged to carefully examine the genitalia of dogs imported to the UK from countries with enzootic TVT.

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Canine transmissible venereal tumor genome reveals ancient introgression from coyotes to pre-contact dogs in North America

Cited by 9 publications

References 15 publications

Genomic Approaches Reveal an Endemic Subpopulation of Gray Wolves in Southern China

Genomic Approaches Reveal an Endemic Subpopulation of Gray Wolves in Southern China

Germline gene fusions across species reveal the chromosomal instability regions and cancer susceptibility

Temporospatial distribution and country of origin of canine transmissible venereal tumours in the UK

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