Canine transmissible venereal tumor genome reveals ancient introgression from coyotes to arctic sled dogs

Wang, Xuan; Zhou, Bowen; Yin, Tingting; Chen, Fang-Liang; Esmailizadeh, Ali; Turner, Melissa M.; Poyarkov, Andrei D.; Savolainen, Peter; Wang, Guodong; Fu, Qiaomei; Zhang, Yaping

doi:10.1101/350512

Cited by 1 publication

(1 citation statement)

References 13 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Thus, we applied the software GATK with the Unified Genotyper parameter to determine diploid calls [27]. We also included 79 canids from previous studies [28,29], including an ancient gray wolf, Taimyr [30], 25 modern gray wolves chosen from regions overlapping the current ranges [3,7,18,19,[31][32][33][34], 46 domestic dogs from all over the world [3,31,35,36], two jackals [33], two coyotes [33], one red wolf…”

Section: Resultsmentioning

confidence: 99%

Genomic approaches reveal an endemic sub-population of gray wolves in Southern China

Wang

Zhang

Wang

et al. 2019

Preprint

Self Cite

View full text Add to dashboard Cite

Despite being one of the most widely distributed terrestrial mammals, the history of gray wolves (Canis lupus) in China is not well understood as their habitats have been destroyed with growing economic development. Using six specimens from wolf skins in Chinese Natural History museums, we sequenced their genome using a modified ancient DNA procedure. Using whole genome sequence analysis, we showed that gray wolves from Southern China (SC) derive from a single lineage, distinct from gray wolves from the Tibetan Plateau (Canis lupus chanco) and Northern China, suggesting that SC gray wolves may form a distinct sub-population. Of SC gray wolves, one wolf from Zhejiang carries a genetic component from a canid that must have diverged earlier from other wolves than jackals did, perhaps through gene flow from a population related to or further diverged from wolves than the dhole, a species distributed in Southern China and Southeast Asia. This may indicate that interspecific gene flow likely played an important role in shaping the speciation patterns and population structure in the genus Canis. Our study is the first to survey museum genomes of gray wolves from Southern China, revealing the presence of an endemic population with ancient interspecific gene flow from a population related to the dhole, and highlighting how sequencing the paleogenome from museum specimens can help us to study extinct species.

show abstract