Canine Respiratory Coronavirus: An Emerging Pathogen in the Canine Infectious Respiratory Disease Complex

Erles, Kerstin; Brownlie, Joe

doi:10.1016/j.cvsm.2008.02.008

Cited by 91 publications

(106 citation statements)

References 32 publications

(54 reference statements)

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“…Infection with CRCoV is associated with mild clinical signs, including nasal discharge, cough, and sneezing. 70 Experimental CRCoV infection of dogs resulted in mild respiratory disease, with virus infecting most respiratory tissue and respiratory associated lymphoid tissue, such as the tonsils and local lymph nodes. Infection of lymphoid tissue is associated with histopathologic changes that include damage to or loss of respiratory cilia.…”

Section: Canine Respiratory Coronavirusmentioning

confidence: 99%

Canine Infectious Respiratory Disease

Reagan

Sykes

2020

Veterinary Clinics of North America: Small Animal Practice

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Section: Canine Respiratory Coronavirusmentioning

confidence: 99%

Canine Infectious Respiratory Disease

Reagan

Sykes

2020

Veterinary Clinics of North America: Small Animal Practice

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“…Since its initial discovery in 2003 (Erles et al, 2003); canine respiratory coronavirus (CRCoV) is now considered to be a significant CIRD pathogen, most frequently detected in dogs with mild respiratory clinical signs during the early stages of CIRD onset (Erles et al, 2003). Although CRCoV has been found worldwide (Decaro et al, 2007;Erles and Brownlie, 2008;Kaneshima et al, 2006;Priestnall et al, 2006Priestnall et al, , 2007Yachi and Mochizuki, 2006;Knesl et al, 2009); little is known regarding its pathogenesis, tissue tropism or virulence differences among global isolates in the canine host.…”

mentioning

confidence: 99%

Tropism and pathological findings associated with canine respiratory coronavirus (CRCoV)

Mitchell

Brooks

Szladovits

et al. 2013

Veterinary Microbiology

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Canine infectious respiratory disease (CIRD) occurs frequently in densely housed dog populations. One of the common pathogens involved is canine respiratory coronavirus (CRCoV), however little is known regarding its pathogenesis and the role it plays in the development of CIRD. The pathogenesis of five geographically unrelated canine respiratory coronavirus (CRCoV) isolates was investigated. Following experimental infection in dogs, all five CRCoV isolates gave rise to clinical signs of respiratory disease consistent with that observed during natural infection. The presence of CRCoV was associated with marked histopathological changes in the nares and trachea, with loss and damage to tracheal cilia, accompanied by inflammation. Viral shedding was readily detected from the oropharynx up to 10 days post infection, but there was little or no evidence of rectal shedding. The successful re-isolation of CRCoV from a wide range of respiratory and mucosal associated lymphoid tissues, and lung lavage fluids demonstrates a clear tropism of CRCoV for respiratory tissues and fulfils the final requirement for Koch's postulates. By study day 14 dogs had seroconverted to CRCoV and the antibodies raised were neutralising against both homologous and heterologous strains of CRCoV in vitro, thus demonstrating antigenic homogeneity among CRCoV strains from the two continents. Defining the role that CRCoV and other agents play in CIRD is a considerable, but important, challenge if the disease is to be managed, treated and prevented more successfully. Here we have successfully developed a model for studying the pathogenicity and the role of CRCoV in CIRD.

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“…Alternatively, BCoV and bovine-like CoVs may have arisen from a common ancestor (Vijgen et al, 2006). Unlike the group 1a enteric canine coronaviruses (CCoVs) types I and II (for a review, see CRCoV has been associated with mild respiratory signs and has been proposed as an etiological agent of canine infectious respiratory disease (CIRD) together with Bordetella bronchiseptica, canine adenovirus types 1 and 2, canine parainfluenza virus, canine herpesvirus, reoviruses and influenza viruses (Erles et al, 2004;Buonavoglia and Martella, 2007;Erles and Brownlie, 2008). CRCoV has been detected firstly in UK in 2003 (Erles et al, 2003) and subsequently in Italy (Decaro et al, 2007).…”

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confidence: 99%

Molecular characterization of a canine respiratory coronavirus strain detected in Italy

Lorusso¹,

Desario²,

Mari³

et al. 2009

Virus Research

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Coronaviruses (CoVs) are positive-stranded, non-segmented RNA viruses generally responsible for the emergence of respiratory and enteric disease in humans, companion animals and livestock. Their aptitude to evolve by genetic recombination and/or point mutation is recognized, thus giving rise to new viral genotypes and mutants with different tissues or host tropism. In particular, a probable origin from the strictly related bovine coronavirus (BCoV) or, alternatively, from a common ancestor has been suggested for some group 2a CoVs, including canine respiratory coronavirus (CRCoV). In this study, we report the sequence analysis of the viral RNA 3'-end of an Italian CRCoV, strain 240/05, together with the sequence comparison with extant bovine-like viruses including the sole CRCoV strain 4182 previously described. Interestingly, although the structural proteins show the same features of CRCoV 4182, the genomic region between the spike and the envelope protein genes of CRCoV 240/05 encodes for three distinct products, including the equivalent bovine 4.9 kDa non-structural protein and a truncated form of the 4.8 kDa protein, whereas CRCoV 4182 has a unique 8.8 kDa protein.

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Canine Respiratory Coronavirus: An Emerging Pathogen in the Canine Infectious Respiratory Disease Complex

Cited by 91 publications

References 32 publications

Canine Infectious Respiratory Disease

Canine Infectious Respiratory Disease

Tropism and pathological findings associated with canine respiratory coronavirus (CRCoV)

Molecular characterization of a canine respiratory coronavirus strain detected in Italy

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