Canine papillomavirus types 1 and 2 in classical papillomas: High abundance, different morphological associations and frequent co-infections

Lange, Christian E.; Jennings, Sammuel; Diallo, Alos; Lyons, Jeremiah A.

doi:10.1016/j.tvjl.2019.05.016

Cited by 13 publications

(11 citation statements)

References 22 publications

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“…The only papillomavirus amplified from these lesions was CPV‐1. As this is a common cause of canine viral papillomas, 8 the unusual repeated recurrence of papillomas does not appear to be due to an unusual type of causative papillomavirus. However, the possibility that these papillomas were caused by a second papillomavirus type that was not amplified by the consensus primers used cannot be definitively excluded.…”

Section: Discussionmentioning

confidence: 95%

Long‐term recurrent, yet nonprogressive, pedal viral papillomas in a dog

Munday¹,

Piripi

Julian

et al. 2020

Veterinary Dermatology

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Résumé Les papillomes viraux développés sur le doigt d’un chien ont été retirés et ont récidivés à quatre reprises en deux ans. Malgré la « persistance » des papillomes, ils sont restés petits et confinés aux doigts, et n’ont pas disséminés ou ne se sont pas aggravés. Tous les papillomes persistants ne progressent pas, même si ils sont traités avec des traitements plus conservateurs.

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Section: Discussionmentioning

confidence: 95%

Long‐term recurrent, yet nonprogressive, pedal viral papillomas in a dog

Munday¹,

Piripi

Julian

et al. 2020

Veterinary Dermatology

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“…Furthermore, other types have been identified in the oral cavity, namely CPV types 2, 4, 8, 13, 17 and 19 ( Munday et al, 2016 ; Tisza et al, 2016 ; Lange et al, 2019 ). In the USA, CPV2 and CPV19 were identified together with CPV1 in a case of coinfection of oral papillomatosis ( Tisza et al , 2016 ).…”

Section: Genetic Diversity and Pathogenicitymentioning

confidence: 99%

“…In the USA, CPV2 and CPV19 were identified together with CPV1 in a case of coinfection of oral papillomatosis ( Tisza et al , 2016 ). Another study demonstrated the coinfection of canine papillomavirus with CPV1 and CPV2 together but in different lesions: cutaneous and eyelid conjunctiva papillomas ( Lange et al ., 2019 ). CPV13 and 17 were identified in samples from New Zealand and Switzerland, respectively.…”

Section: Genetic Diversity and Pathogenicitymentioning

confidence: 99%

New insights into Canis familiaris papillomaviruses genetics and biology: Is the genetic characterization of CPV types and their variants an important clinical issue?

Reis

Batista

2022

Genet. Mol. Biol.

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Canis familiaris papillomavirus (CPV) is a member of the Papillomaviridae family and is found in dogs. After infection, the host can remain asymtomatic or develop benign ephitelial neoplasms such as papillomas and pigmented viral plaques, which can progress to cancer, in the form of squamous cell carcinoma (SCC). In humans, 227 types of human papillomavirus (HPV) have been described, with a well-established risk classification for cancer development. In addition, it is also known that variants of some high-risk HPV types may present different risks in respect of SCC development. In dogs, however, only a few types of CPV have been identified, despite the growing interest in this area, and knowledge on the genetic characterization of CPV variants is still scarce. Recent studies of CPV have shown that, as with HPV, benign neoplasia can develop into cancer, but it is believed that there are many more types and variants still to be described. Therefore, the aim of this study was to describe the genetics and biology of CPV, with the focus on what is known about lesions, geographic localization, virus types and variants.

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“…ab2417, Abcam, Cambridge, UK) were 100-fold diluted in PBST and applied to the slides for incubation for one hour at room temperature. This antibody broadly reacts to several types of CPV, BPV, HPV, and Zalophus papillomavirus [38][39][40][41][42]. The endogenous peroxidase activity was blocked by incubating the slides with 3% H2O2 in methanol for 10 min.…”

Section: Immunohistochemistry Staining Of Viral Antigensmentioning

confidence: 99%

The Detection and Association of Canine Papillomavirus with Benign and Malignant Skin Lesions in Dogs

Chang

Chen

Haga

et al. 2020

Viruses

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Papillomavirus (PV) mainly infects the squamous epithelium and may potentially lead to benign or even malignant cutaneous lesions. However, the malignant transforming ability has been identified in several types of PVs. In humans, papillomavirus (HPV) type 16 and 18 are the most prevalent causative agents of cervical cancer. Therefore, vaccines are being developed to protect against these types. For dogs, there have been limited investigations into the association of different canine papillomavirus (CPV) genotypes with malignant lesions. Understanding the high-risk CPV genotype(s) responsible for these malignant lesions would contribute to the development of interventions for preventing CPV-induced carcinomas. In the present study, a retrospective cohort of 102 pathologically confirmed papillomas and 212 squamous cell carcinomas (SCCs) were included. The viral genome and antigens in the formalin-fixed paraffin-embedded (FFPE) tissues were detected using PCR targeting pan PV E1 and COPV L1 genes and by immunohistochemistry staining (IHC), respectively. PVs were successfully detected from 11 FFPE cutaneous tissues and four oral tissues using pan PV E1- and COPV L1-based PCR, respectively. After sequencing, CPV 1, CPV 2, and CPV 6 were detected in the benign lesions using PCR and were confirmed through IHC. While CPV 9 and CPV 15 were first detected in the SCCs of dogs, CPV 16 was most often detected in SCC specimens. The association and confirmative demonstration of viral genes and intralesional antigens of CPV 9, CPV 15, and CPV 16 in SCCs highlight the potential risk of these genotypes of CPVs in malignant transformation.

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Canine papillomavirus types 1 and 2 in classical papillomas: High abundance, different morphological associations and frequent co-infections

Cited by 13 publications

References 22 publications

Long‐term recurrent, yet nonprogressive, pedal viral papillomas in a dog

Long‐term recurrent, yet nonprogressive, pedal viral papillomas in a dog

New insights into Canis familiaris papillomaviruses genetics and biology: Is the genetic characterization of CPV types and their variants an important clinical issue?

The Detection and Association of Canine Papillomavirus with Benign and Malignant Skin Lesions in Dogs

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