Canine leishmaniasis due to<i>Leishmania infantum</i>MON-1 in northern Morocco

Nejjar, R.; Lemrani, Meryem; Malki, A.; Ibrahimy, S; Amarouch, Hamid; Benslimane, A.

doi:10.1051/parasite/1998054325

Cited by 37 publications

(25 citation statements)

References 7 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Epidemiological surveys in the pre-Saharan area show that P. longicuspis is suspected in the transmission of the VL in the south of Morocco (Dereure et al 1986). This finding agrees with the results from another survey of L. infantum reservoirs that showed increased seroprevalence at intermediate altitudes between 500 and 1,000 m (Nejjar et al 1998). Generally, the role of Larroussius species in the transmission of L. infantum remains to be specified.…”

Section: Larroussius Sppsupporting

confidence: 90%

Spatial relations among environmental factors and phlebotomine sand fly populations (Diptera: Psychodidae) in central and southern Morocco

Kahime

Boussaa

Mzabi³

et al. 2015

Journal of Vector Ecology

View full text Add to dashboard Cite

Phlebotomine sand flies (Diptera: Psychodidae, Phlebotominae) are of considerable public health importance because of their ability to transmit several human parasites, mainly as vectors of Leishmania spp. Over the past decade, the epidemiological situation of cutaneous leishmaniasis (CL) has significantly increased with its geographic expansion to previously free areas and the emergence of overlapping foci of cutaneous leishmaniasis and visceral leishmaniasis (VL) in several provinces of Morocco. A total of 15,313 specimens was collected during this entomological survey. The genera Phlebotomus (57.38%) and Sergentomyia (42.62%) were identified. Sergentomyia minuta (22.01%) was the most prevalent species, followed by S. fallax (18.21%), Phlebotomus perniciosus (14.35%), P. papatasi (14.06%), P. sergenti (12.85%), P. longicuspis (10.74%), P. ariasi (2.68%), S. dreyfussi (1.53%), P. alexandri (1.31%), P. bergeroti (1.14%), S. christophersi (0.62%), S. africana (0.25%), P. chabaudi (0.14%), P. chadlii (0.05%), and P. kazeruni (0.04%). We aimed to determine current distribution of leishmaniases vectors, their ecological characteristics, and the significance of the predominant species at any bioclimate stage, altitude range, and soil texture in terms of the risk of leishmaniasis transmission. Journal of Vector Ecology 40 (2): 342-354. 2015.

show abstract

Section: Larroussius Sppsupporting

confidence: 90%

Spatial relations among environmental factors and phlebotomine sand fly populations (Diptera: Psychodidae) in central and southern Morocco

Kahime

Boussaa

Mzabi³

et al. 2015

Journal of Vector Ecology

View full text Add to dashboard Cite

show abstract

“…L. infantum is also responsible for widespread visceral leishmaniasis in the North-Eastern slope of the Rif Mountains, the most active area of this form of the disease. The dog is the main domestic reservoir of the species [7]. Among about 20 sand fly species that play a significant role in the transmission of Leishmania parasites in the Mediterranean basin, members of the subgenus Larroussius represent the most important vectors of L. infantum [8-10].…”

Section: Introductionmentioning

confidence: 99%

“…In 2008, the Moroccan Ministry of Health reported 9 VL cases and 64 CL cases spread over several sites belonging to Sefrou province, the causative agents of CL and VL were identified as L. tropica [12] and L. infantum , respectively [7,13,14]. Despite the large number of foci of CL and VL in this province, the vectors have never been identified with certainty.…”

Section: Introductionmentioning

confidence: 99%

Molecular detection and identification of Leishmania infection in naturally infected sand flies in a focus of cutaneous leishmaniasis in northern Morocco

et al. 2014

View full text Add to dashboard Cite

BackgroundCutaneous leishmaniasis is an infectious disease caused by various species of the flagellate protozoan Leishmania. During the past 20 years, cutaneous leishmaniasis has emerged as a major public health threat in Morocco. The main objective of this study was to study the occurrence of Leishmania infection in vectors and to identify sand fly blood meal sources in an endemic locality of cutaneous leishmaniasis within Sefrou province, where the vectors of leishmaniasis were still unknown.Methods2650 sand flies were collected using CDC miniature light traps and identified morphologically. The identified sand flies were tested for Leishmania infection by nested PCR. The source of blood meal of 10 freshly engorged females: 6 Phlebotomus longicuspis and 4 Phlebotomus sergenti, was determined using the Cyt b sequence.ResultsThe collected sand flies consisted of 10 species, seven of which belonged to the genus Phlebotomus and three to the genus Sergentomyia. The most abundant species was P. longicuspis, accounting for 72% of the total sand flies collected. In females of three P. longicuspis and four P. sergenti, Leishmania infantum and Leishmania tropica DNA was detected, respectively.The source of blood meal of engorged females showed that all sand flies tested fed on humans.ConclusionsWe report for the first time the natural infection of P. longicuspis with L. infantum in Morocco. The high frequency of this species in this region, in addition to its anthropophilic character make P. longicuspis the putative vector of L. infantum in this cutaneous leishmaniasis focus where L. tropica is confirmed as the causative agent of the disease and P. sergenti as its vector. The presence of L. infantum, and its presumed vector in this area, makes this a site of high risk of visceral leishmaniasis, mostly because of the proximity of a focus of human and canine visceral leishmaniasis.

show abstract

“…Three different forms of cutaneous leishmaniasis (CL) occur in distinct geographical areas of Morocco: (i) zoono-tic cutaneous leishmaniasis (ZCL) is epidemic in southern Morocco and is known to be caused by Leishmania major (Zymodeme MON25) [4]; (ii) a chronic form of cutaneous leishmaniasis is encountered in the center and North of Morocco and is due to Leishmania tropica [5,6], and (iii) a sporadic form occurs in northern Morocco, which is caused by Leishmania infantum, the causative agent of human and canine visceral leishmaniasis in the same area [7,8].…”

Section: Introductionmentioning

confidence: 99%

Antileishmanial and Antibacterial Activity of a New Pyrazole Derivative Designated 4‐[2‐(1‐(Ethylamino)‐2‐methyl‐ propyl)phenyl]‐3‐(4‐methyphenyl)‐1‐phenylpyrazole

Dardari

Lemrani

Sebban

et al. 2006

Archiv der Pharmazie

View full text Add to dashboard Cite

Here, we report for the first time the synthesis and the antileishmanial activity of a new pyrazole derivative, namely 4-[2-(1-(ethylamino)-2-methylpropyl)phenyl]-3-(4-methyphenyl)-1-phenylpyrazole). Micromolar concentrations of this compound were found to inhibit the in vitro multiplication of Leishmania tropica, Leishmania major, and Leishmania infantum, three species causing different forms of leishmaniasis. Furthermore, the 50% inhibitory concentration (IC50) values for the compound are only slightly higher than those of amphotericin B, one of the most active antileishmanial agents used as a satisfactory substitute in cases not responding to pentostam. The IC50 values after 48 h for L. tropica, L. major, and L. infantum promastigote growth were 0.48 microg/mL, 0.63 microg/mL and 0.40 microg/mL, respectively for the compound, while they were 0.23 microg/mL, 0.29 microg/mL and 0.24 microg/mL, respectively for amphotericin B. We also tested this compound for its antibacterial activity against several bacteria. The strongest antibacterial activity was observed against Entrococcus feacalis and Staphylococcus aureus with a minimal inhibitory concentration (MIC) of 60 microg/mL.

show abstract

Canine leishmaniasis due toLeishmania infantumMON-1 in northern Morocco

Cited by 37 publications

References 7 publications

Spatial relations among environmental factors and phlebotomine sand fly populations (Diptera: Psychodidae) in central and southern Morocco

Spatial relations among environmental factors and phlebotomine sand fly populations (Diptera: Psychodidae) in central and southern Morocco

Molecular detection and identification of Leishmania infection in naturally infected sand flies in a focus of cutaneous leishmaniasis in northern Morocco

Antileishmanial and Antibacterial Activity of a New Pyrazole Derivative Designated 4‐[2‐(1‐(Ethylamino)‐2‐methyl‐ propyl)phenyl]‐3‐(4‐methyphenyl)‐1‐phenylpyrazole

Contact Info

Product

Resources

About