Canine Influenza Virus Replicates in Alveolar Macrophages and Induces TNF-α

Je, Powe; Castleman, W. L.

doi:10.1354/vp.08-vp-0229-p-fl

Cited by 15 publications

(8 citation statements)

References 41 publications

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“…Most studies have focused on IAV infection and replication in murine and human macrophages, with few studies investigating the potential for IAV to replicate in avian macrophages, or macrophages from other mammalian hosts [90][91][92]. Lymphoid necrosis associated with virulent H5N9 IAV infection of chickens correlated with the ability of the virus to infect macrophages [93].…”

Section: Discussionmentioning

confidence: 99%

Influenza virus replication in macrophages: balancing protection and pathogenesis

Cline

Beck

Bianchini

2017

Journal of General Virology

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Macrophages are essential for protection against influenza A virus infection, but are also implicated in the morbidity and mortality associated with severe influenza disease, particularly during infection with highly pathogenic avian influenza (HPAI) H5N1 virus. While influenza virus infection of macrophages was once thought to be abortive, it is now clear that certain virus strains can replicate productively in macrophages. This may have important consequences for the antiviral functions of macrophages, the course of disease and the outcome of infection for the host. In this article, we review findings related to influenza virus replication in macrophages and the impact of productive replication on macrophage antiviral functions. A clear understanding of the interactions between influenza viruses and macrophages may lead to new antiviral therapies to relieve the burden of severe disease associated with influenza viruses.

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Section: Discussionmentioning

confidence: 99%

Influenza virus replication in macrophages: balancing protection and pathogenesis

Cline

Beck

Bianchini

2017

Journal of General Virology

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“…58 Although it is not clear if the pulmonary source of interleukin-10 is T lymphocytes or macrophages, there is experimental evidence that this cytokine plays an important role in increasing susceptibility to bacterial pneumonia following influenza infection. 69 There is no specif ic treatment for CIV infection. Antibiotics are important for treating the secondary bacterial infections that are commonly associated with H3N8 CIV infections.…”

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confidence: 99%

A review of the pathology and treatment of canine respiratory infections

Vieson¹,

Piñeyro²,

LeRoith³

2012

VMRR

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Numerous infectious agents are responsible for causing primary or secondary respiratory disease in dogs. These agents can cause upper or lower respiratory infections commonly observed in veterinary practices. Clinical signs might vary from mild dyspnea, sneezing, and coughing to severe pneumonia with systemic manifestations. Depending on the etiologic agent, the gross and microscopic changes observed during these infections can be rather unspecific or have highly characteristic patterns. While histopathology and cytology are not always required for diagnosis of respiratory infections, they are often useful for establishing a definitive diagnosis and identifying specific etiologic agents. Research regarding epidemiology, pathogenesis, diagnostics, and clinical manifestations related to these infectious pathogens provides valuable information that has improved treatments and management of the diseases they cause. This review discusses the epidemiology, general clinical characteristics, and pathologic lesions for some of the important viral, bacterial, fungal, and parasitic etiologies of canine respiratory disease.

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“…The most important pro-inflammatory cytokines that are responsible for these reactions are IL-6 and TNF-α. These cytokines are pleiotropic inflammatory cytokines that play important roles in metabolism, apoptosis, massive systemic effects and inflammation, which are hallmarks of influenza [14-16]. …”

Section: Discussionmentioning

confidence: 99%

Attenuation of influenza virus infectivity with herbal-marine compound (HESA-A): an in vitro study in MDCK cells

Mehrbod

Ideris

Omar

et al. 2012

Virol J

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BackgroundThe influenza virus is still one of the most important respiratory risks affecting humans which require effective treatments. In this case, traditional medications are of interest. HESA-A is an active natural biological compound from herbal-marine origin. Previous studies have reported that the therapeutic properties of HESA-A are able to treat psoriasis vulgaris and cancers. However, no antiviral properties have been reported.MethodsThis study was designed to investigate the potential antiviral properties of HESA-A and its effects in modulating TNF-α and IL-6 cytokine levels. HESA-A was prepared in normal saline as a stock solution (0.8 mg/ml, pH = 7.4). Percentages of cell survival when exposed to different concentrations of HESA-A at different time intervals was determined by MTT assay. To study the potential antiviral activity of HESA-A, Madin-Darby Canine Kidney (MDCK) cells were treated with the effective concentration (EC50) of HESA-A (0.025 mg/ml) and 100 TCID50/0.1 ml of virus sample under different types of exposure.ResultsBased on the MTT method and hemagglutination assay (HA), HESA-A is capable of improving cell viability to 31% and decreasing HA titre to almost 99% in co-penetration exposures. In addition, based on quantitative real-time PCR (qRT-PCR) and enzyme-linked immunosorbent assay (ELISA), it was found that HESA-A causes decrements in TNF-α and IL-6 cytokine expressions, which was significant for TNF-α (p ≤ 0.05) but not for IL-6.ConclusionIn conclusion, HESA-A was effective against influenza infection through suppressing cytokine expression.

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Canine Influenza Virus Replicates in Alveolar Macrophages and Induces TNF-α

Cited by 15 publications

References 41 publications

Influenza virus replication in macrophages: balancing protection and pathogenesis

Influenza virus replication in macrophages: balancing protection and pathogenesis

A review of the pathology and treatment of canine respiratory infections

Attenuation of influenza virus infectivity with herbal-marine compound (HESA-A): an in vitro study in MDCK cells

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