Canine Fecal Microbiota Transplantation: Current Application and Possible Mechanisms

Tuniyazi, Maimaiti; Hu, Xiaoyu; Fu, Yunhe; Zhang, Naisheng

doi:10.3390/vetsci9080396

Cited by 18 publications

(19 citation statements)

References 85 publications

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“…Beeinflusst wird die Mikrobiota v. a. durch die Fütterung, gastrointestinale Erkrankungen und den Einsatz von Medikamenten 4 . Eine Studie, die die Langzeitfolgen eines 7-tägigen Tylosin-Einsatzes auf das intestinale Mikrobiom untersuchte, konnte zeigen, dass sich erst nach 63 Tagen die Bakteriendiversität nicht mehr signifikant von der vor der Tylosin-Gabe unterschied 5 .…”

Section: Aufgaben Der Darmmikrobiotaunclassified

“…Allerdings konnten nach 2 Monaten noch vermehrt primäre Gallensäuren in den Fäzes der Hunde nachgewiesen werden, was darauf hindeutet, dass die Folgen der Antibiotikagabe noch länger präsent sind 5 . Andere Faktoren, die die Darmmikrobiota verändern können, sind Übergewicht, eine Gravidität oder extragastrointestinale Erkrankungen wie beispielsweise Diabetes mellitus 4 .…”

Section: Aufgaben Der Darmmikrobiotaunclassified

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Braunes Gold – Kottransplantation als Therapieoption beim Hund

Dinkel,

Dahlem

2024

kleintier konkret

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Section: Aufgaben Der Darmmikrobiotaunclassified

Braunes Gold – Kottransplantation als Therapieoption beim Hund

Dinkel,

Dahlem

2024

kleintier konkret

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“…Here, we proposed three possible mechanisms of action involved in the VMT therapy, including increased competition for nutrition, increased production of bactericide, virucide and hydrogen peroxide (H2O2), and specific adhesion to epithelial cells. These are based on the role of healthy vaginal microbiota in maintaining vaginal health as well as are adapted from previous studies that discussed possible mechanisms of FMT in humans and dogs [71,72].…”

Section: Possible Mechanisms Of Vaginal Microbiota Transplantationmentioning

confidence: 99%

Vaginal Microbiota Transplantation: Possible Mechanisms and Future Perspectives

Tuniyazi¹,

Li²,

Fu³

et al. 2023

Preprint

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The human body is inhabited by unique microbial communities that protect and regulate the host against pathogens and inflammation. To address issues related to disrupted microbial composition, microbial transfer therapy (MTT) has emerged as a potential treatment option. The most popular form of MTT is fecal microbiota transplantation (FMT), which has been successful in treating various diseases. Another emerging form of MTT is vaginal microbiota transplantation (VMT), transferring of the vaginal microbiota from a healthy female donor to a diseased patient's vaginal cavity, which aims to restore normal vaginal microbial composition. However, VMT is vastly unexplored due to safety concerns and lack of research. This paper explores the mechanisms involved in VMT's therapeutic effect and discusses future perspectives. Further research is needed to advance VMT's clinical applications and techniques.

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“…These perturbations to fecal microbiome composition can directly impact host health. Recent research shows that Fecal Microbiota Transplants (FMT), which involve the transfer of fecal microbes from a healthy donor into the gastrointestinal tract of a recipient animal, show promise in treating or preventing a range of health conditions and improving health outcomes [17][18][19]. FMTs can repopulate the microbiome and restore fecal microbiome composition, diversity, and homeostasis by increasing microbiome diversity, enhancing the numbers of beneficial microbes, or outcompeting pathogens [17][18][19].…”

Section: Introductionmentioning

confidence: 99%

“…Recent research shows that Fecal Microbiota Transplants (FMT), which involve the transfer of fecal microbes from a healthy donor into the gastrointestinal tract of a recipient animal, show promise in treating or preventing a range of health conditions and improving health outcomes [17][18][19]. FMTs can repopulate the microbiome and restore fecal microbiome composition, diversity, and homeostasis by increasing microbiome diversity, enhancing the numbers of beneficial microbes, or outcompeting pathogens [17][18][19]. FMTs can be an alternative to conventional treatment methods (particularly if these have proven ineffective) or they can supplement already existing treatment methods for an enhanced resolution of clinical signs.…”

Section: Introductionmentioning

confidence: 99%

Microbiome Responses to Fecal Microbiota Transplantation in Cats with Chronic Digestive Issues

Rojas¹,

Entrolezo²,

Jarett³

et al. 2023

Preprint

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There is growing interest in the application of fecal microbiota transplants (FMTs) in small animal medicine, but there are few published studies that have tested their effectiveness in the domestic cat (Felis catus). Here we use 16S rRNA gene sequencing to examine fecal microbiome changes in 68 domestic cats with chronic digestive issues that underwent FMT treatment using lyophilized stool that was delivered in oral capsules. Fecal samples were collected from FMT recipients before and two weeks after treatment, as well as from their stool donors, and healthy animals. We found that according to their owners, 77% of cats were reported to show improvement in their clinical signs (termed ‘Responders’), and 23% were reported to exhibit no change or a worsening of their clinical signs (termed ‘Non-Responders’). Variation in the fecal microbiomes of FMT recipients most strongly correlated with host clinical signs, diet, and IBD diagnosis. The relative abundances of Collinsella, Negativibacillus, Parabacteroides, and Peptoclostridium changed differentially in FMT recipients. Overall, on average 13% of the bacterial amplicon sequence variants (ASVs) were shared between stool donors and FMT recipients (excluding ASVs already present in FMT recipients prior to treatment). The most commonly shared ASVs were classified as Prevotella 9, Peptoclostridium, Bacteroides, Collinsella and unclassified Lachnospiraceae. Lastly, FMT recipients that had recently taken antibiotics exhibited increases in microbiome similarity to an age-matched healthy reference set compared to other cats. Cats that had diarrhea or diarrhea with vomiting became more similar to healthy cats than did cats exhibiting other clinical signs. Overall, our results suggest that oral capsule FMT treatment was effective in this group of cats and microbiome responses may be modulated by the FMT recipient’s initial presenting clinical signs, prior IBD diagnosis, recent antibiotic use, and their diet.

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Canine Fecal Microbiota Transplantation: Current Application and Possible Mechanisms

Cited by 18 publications

References 85 publications

Braunes Gold – Kottransplantation als Therapieoption beim Hund

Braunes Gold – Kottransplantation als Therapieoption beim Hund

Vaginal Microbiota Transplantation: Possible Mechanisms and Future Perspectives

Microbiome Responses to Fecal Microbiota Transplantation in Cats with Chronic Digestive Issues

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