Canine cryptorchism and subsequent testicular neoplasia: Case‐control study with epidemiologic update

Hayes, Howard M.; Wilson, George; Pendergrass, Thomas W.; Cox, Victor S

doi:10.1002/tera.1420320108

Cited by 91 publications

(75 citation statements)

References 17 publications

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“…In Taiwan, most residents live in a city and their companion animals are small or toy size. Numerous small or toy size breeds were mentioned as high risk in regards to cryptorchid testes, including the Miniature, Toy and Standard Poodles, Chihuahua, Yorkshire Terrier, and Miniature Schnauzer [7,13,17]. Moreover, since cryptorchidism is associated with testicular tumors, these small size dogs should be at high risk for testicular tumors [17].…”

Section: Discussionmentioning

confidence: 99%

A 12-Year Retrospective Study of Canine Testicular Tumors

et al. 2009

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ABSTRACT. To provide up-to-date information on the incidence and risk factors of canine testicular tumors, 476 pathological reports of male canine tumors from two institutes of veterinary medicine in Taiwan Cryptorchidism was significantly associated with development of MGCSCTs, SCTs, and SEMs, but not ICTs (p<0.01). The detection rate of testicular tumors in the dog younger than 10-years-old was significantly associated with cryptorchidism (p<0.01). Except for mixed breed dogs, the Maltese breed had high detection rate of testicular tumors, and may have high risk in cryptorchidism in this study.In conclusion, our results indicate that cryptorchidism alone or in addition to age will significantly affect the incidence and type of canine testicular tumors, and a high detection rate of testicular tumors in Maltese dogs is documented for the first time.

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Section: Discussionmentioning

confidence: 99%

A 12-Year Retrospective Study of Canine Testicular Tumors

et al. 2009

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“…The three main types of testicular tumours in dogs are Sertoli cell tumours, seminomas and Leydig cell tumours; mixed tumours are often observed (Nielsen & Kennedy 1990). Cryptorchidism is an important risk factor for the development of testicular tumours, causing a 26-fold increase in the risk for Sertoli cell tumours and a 15-fold increase for seminomas (Hayes et al 1985). Although Sertoli cell tumours and seminomas are considered to be potentially malignant, they seldom metastasise in the dog, whereas seminomas in men are highly malignant (Swerdlow 1993).…”

Section: Introductionmentioning

confidence: 99%

Ageing, testicular tumours and the pituitary-testis axis in dogs

Peters

Jong²,

Teerds³

et al. 2000

Journal of Endocrinology

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Dogs of different ages without testicular diseases were evaluated to study possible age-related changes in hormone concentrations in serum. Dogs with testicular tumours were also investigated to study the relation between tumour type and hormone concentrations; in this study, dogs with Sertoli cell tumours, Leydig cell tumours and seminomas were included. We measured testosterone, oestradiol, LH, FSH and inhibin-like immunoreactivity concentrations in peripheral venous and testicular venous blood of these animals.In normal dogs there appeared to be no age-related changes in the concentrations of the investigated hormones, except for a significant age-related decrease in oestradiol concentrations in testicular venous blood (P<0·02). Dogs with a Sertoli cell tumour had greater oestradiol concentrations and inhibin-like immunoreactivity in both peripheral and testicular venous blood than did dogs without a neoplasm (P<0·05). Testosterone concentrations were reduced in dogs with Sertoli cell tumours, as were FSH and LH. Feminisation occurred in eight of 13 dogs with a Sertoli cell tumour and in two of 14 dogs with a Leydig cell tumour; it was accompanied by a significantly greater oestradiol concentration than in normal dogs and in dogs with Sertoli cell tumours without signs of feminisation. Dogs with a Leydig cell tumour had greater concentrations of oestradiol and inhibin-like immunoreactivity in both peripheral venous and testicular venous blood than did dogs without a neoplasm (P<0·05). The testosterone concentration in testicular venous blood of these dogs was lower than that in dogs with normal testes. The concentration of LH in peripheral venous blood was also reduced (P<0·05). Hormone concentrations in dogs with a seminoma were not different from those in normal dogs.It was concluded that seminomas are not endocrinologically active. In contrast, both Sertoli cell tumours and Leydig cell tumours can cause increased oestrogen production leading to signs of feminisation. These tumours also have considerable amounts of inhibin-like immunoreactivity, but only in Sertoli cell tumours does this result in a reduction in FSH concentrations, suggesting that Sertoli cell tumours secrete dimeric inhibin, whereas Leydig cell tumours presumably produce loose -subunits that cross-react in the inhibin assay but are not biologically active.

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“…The main types of tumors are Sertoli cell tumor (SCT), seminoma and Leydig cell tumor [5,15], and the occurrence rate of SCT in the cryptorchid testes of dogs is known to be much higher than in scrotal testes [14,26].…”

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confidence: 99%

Testicular Superoxide Dismutase Activity, Heat Shock Protein 70 Concentration and Blood Plasma Inhibin-.ALPHA. Concentration of Dogs with a Sertoli Cell Tumor in a Unilateral Cryptorchid Testis

et al. 2007

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ABSTRACT. The proportions of Sertoli cell tumor (SCT), seminoma and Leydig cell tumor in 50 dogs with unilateral testicular tumors were 52%, 36% and 12%, respectively. The rate of occurrence of SCT in the cryptorchid testis was very high (71%). The testicular superoxide dismutase (SOD) activity, testicular heat shock protein (HSP) 70 concentration and peripheral blood plasma inhibin (INH)-α concentration of 10 dogs with a unilateral cryptorchid testis and no testicular tumors, 10 dogs with SCT in a unilateral cryptorchid testis and 10 normal dogs, all aged 5-15 years, were measured in order to identify high risk factors for the occurrence of SCT in the canine cryptorchid testis. The mean SOD activity in cryptorchid testes and SCTs was significantly lower and higher, respectively, than in normal testes (both P<0.01). The mean HSP 70 concentration in both cryptorchid testes and SCTs was significantly higher than in normal testes (both P<0.01). The mean plasma INH-α concentration of the cryptorchid and SCT dogs was significantly lower and higher, respectively, than in normal dogs (P<0.05 and 0.01, respectively). The low SOD activity in the cryptorchid testis, low blood plasma INH-α concentration of the cryptorchid dogs and high HSP 70 concentration in the SCTs may be related to the occurrence of SCT and tumor cell proliferation in canine cryptorchid testes.

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Canine cryptorchism and subsequent testicular neoplasia: Case‐control study with epidemiologic update

Cited by 91 publications

References 17 publications

A 12-Year Retrospective Study of Canine Testicular Tumors

A 12-Year Retrospective Study of Canine Testicular Tumors

Ageing, testicular tumours and the pituitary-testis axis in dogs

Testicular Superoxide Dismutase Activity, Heat Shock Protein 70 Concentration and Blood Plasma Inhibin-.ALPHA. Concentration of Dogs with a Sertoli Cell Tumor in a Unilateral Cryptorchid Testis

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